Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0178874 (
tumor progression
)
40,807
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aberrant expression of T cell-resident programmed cell death protein-1 (PD-1) is known to promote
tumor progression
. A recent study (Nature 2018;564:130-135) has now identified the E3 ubiquitin ligase
FBXO38
as a crucial regulator of PD-1 protein turnover in T cells, providing a novel mechanism for potential use in cancer immunotherapy.
...
PMID:FBXO38 Drives PD-1 to Destruction. 3048 6
