Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0178874 (tumor progression)
 40,807 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 53 year-old woman had been followed up since 1996 after receiving bilateral adrenalectomy for the treatment of bilateral adrenal pheochromocytoma in von Hippel-Lindau (VHL) disease. In March 2003, she suffered from cough, dizziness and faint, and was referred to our hospital. The radiographic findings exhibited the presence of hypervascular tumors in the left hilum, left apex of the lung and the left neck. Tumor progression was suspected to occlude the left main pulmonary artery and hormonal assays showed elevated levels of the plasma norepinephrine, which may cause fatal complications. Percutaneous needle biopsy of the left cervical tumor revealed metastatic pheochromocytoma. After embolization of the main feeding artery, surgical resection of the tumor resulted in control of excess catecholamine release and symptoms.
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PMID:Successful surgical treatment for life threatening metastatic thoracic and cervical pheochromocytoma. 1767 Mar 60

Pheochromocytoma is the most common tumor of the adrenal medulla in adults. The lack of sensitive animal models of pheochromocytoma has hindered the study of this tumor and in vivo evaluation of antitumor agents. In this study we generated two sensitive luciferase models using bioluminescent pheochromocytoma cells: an experimental metastasis model to monitor tumor spreading and a subcutaneous model to monitor tumor growth and spontaneous metastasis. These models offer a platform for sensitive, non-invasive and real-time monitoring of pheochromocytoma primary growth and metastatic burden to follow the course of tumor progression and for testing relevant antitumor treatments in metastatic pheochromocytoma.
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PMID:Characterization of two mouse models of metastatic pheochromocytoma using bioluminescence imaging. 2215 86