Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0178874 (
tumor progression
)
40,807
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Loss of immunosurveillance is a major cause of
cancer progression
. Here, we demonstrate that gelsolin, a constituent of ejaculate, induces apoptosis of activated lymphocytes in prostate cancer. Gelsolin was highly expressed in prostate cancer cells, and was associated with
tumor progression
, recurrence, metastasis, and poor prognosis.
In vitro
, secreted gelsolin inactivated CD4
+
T cells by binding to CD37, and induced apoptosis of activated CD8
+
T lymphocytes by binding to Fas ligand during cell contact dependent on major histocompatibility complex I. Moreover, secreted gelsolin bound to sortilin, which in turn bound to
Wiskott-Aldrich syndrome protein family member 3
, thereby enhancing the endocytosis and intracellular transport of essential lipids needed to facilitate tumor growth and expansion. Under normal conditions, gelsolin is a seemingly harmless protein that prevents immune responses in female recipients. In disease states, however, this protein can inhibit immunosurveillance and promote
cancer progression
.
...
PMID:Secreted gelsolin desensitizes and induces apoptosis of infiltrated lymphocytes in prostate cancer. 2910 Mar 77
