Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0162871 (
abdominal aortic aneurysm
)
8,664
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Abdominal aortic aneurysm
(
AAA
) is a fatal disease that is associated with chronic inflammation in the vessel wall.
Cortistatin
is implicated in inflammation, vascular smooth muscle cell migration and other cardiovascular pathologies. But, the hypothetical effect of
cortistatin
on
AAA
remains uncertain. We investigated the effect of
cortistatin
administration to angiotensin (Ang) II-induced
AAA
formation in apolipoprotein E deficient (Apoe
-/-
) mice. We showed that
cortistatin
administration significantly suppresses incidence and severity of
AAA
in Apoe
-/-
mice. A significant increase in macrophage infiltration, excretion of inflammatory cytokines, activities and expression levels of MMP2 and MMP9, reactive oxygen species levels and cell apoptosis in aneurysmal aortic wall of Apoe
-/-
mice infused with Ang-II, and these events were significantly alleviated by co-treatment with
cortistatin
. Mechanistic studies showed that the protective effects of
cortistatin
were related to the blocking of ERK1/2 signaling pathways, while does not was not actually affect JNK, P38 phosphorylation. In conclusion,
cortistatin
appears to play an essential role in the formation of
AAA
and indicate
cortistatin
may as novel therapeutic option for
AAA
.
...
PMID:Cortistatin attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the ERK1/2 signaling pathways. 2922 68
