Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0162871 (
abdominal aortic aneurysm
)
8,664
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Rupture of
abdominal aortic aneurysm
(
AAA
) is a devastating event that can be prevented by inhibiting the growth of small aneurysms. Therapeutic strategies targeting certain events that promote the development of
AAA
must be developed, in order to alter the course of
AAA
. Chronic inflammation of the aortic mural is a major characteristic of
AAA
and is related to
AAA
formation, development and rupture.
Daphnetin
(
DAP
) is a coumarin derivative with anti-inflammatory properties that is extracted from
Daphne odora
var. However, the effect of
DAP
on
AAA
development remains unclear. The present study investigated the effect of
DAP
on the formation and development of experimental AAAs and its potential underlying mechanisms. A mice
AAA
model was established by intra-aortic infusion of porcine pancreatic elastase (PPE), and mice were intraperitoneally injected with
DAP
immediately after PPE infusion. The maximum diameter of the abdominal aorta was measured by ultrasound system, and aortic mural changes were investigated by Elastica van Gieson (EVG) staining and immunohistochemical staining. The results demonstrated that
DAP
significantly suppressed PPE-induced
AAA
formation and attenuated the depletion of aortic medial elastin and smooth muscle cells in the media of the aorta. Furthermore, the density of mural macrophages, T cells and B cells were significantly attenuated in
DAP
-treated
AAA
mice. In addition, treatment with
DAP
resulted in a significant reduction in mural neovessels. These findings indicated that
DAP
may limit the formation and progression of experimental aneurysms by inhibiting mural inflammation and angiogenesis. These data confirmed the translational potential of
DAP
inclinical
AAA
inhibition strategies.
...
PMID:Daphnetin suppresses experimental abdominal aortic aneurysms in mice via inhibition of aortic mural inflammation. 3319 36
