Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162871 (abdominal aortic aneurysm)
 8,664 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

About 75% of AAAs are asymptomatic. They come to light as the chance findings of a lump with or without pulsation, noted on self-examination, a routine physical check-up, or during diagnostic investigations. Ultrasonography and CT are two most often used in diagnosing of AAAs. The aim of the study was the assessment of the diagnostic value of computed tomography and ultrasonography in the evaluation of abdominal aortic aneurysm. Material comprises a group of 26 patients with abdominal aortic aneurysm. There were 18 men and 8 women, aged between 48 and 76 years (mean age 62 years). In each patient computed tomography and ultrasound examinations were performed. Computed tomography is more accurate technique than ultrasonography. In obese patients or in the presence of gas in the bowel the abdominal aorta may be invisible in ultrasonography, but is easily and clearly visualized in CT. Measurements of aneurysm diameters are much more reliable in CT than in ultrasonography. In CT it is possible to imagine and measure the length of the aneurysm in various MPR reconstructions. The bifurcation of the aorta and iliac arteries are well imagined in CT. The coexistent aneurysms of thoracic aorta are easily diagnosed just by performing few additional sections of the thoracic aorta. In properly prepared patients ultrasonography provides good imaging modality in performed screening examination, and in controlling patients with small aneurysm because it is widely accessible and cheap. In preoperative assessment the CT examination is necessary.
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PMID:Abdominal aortic aneurysm in ultrasound and CT examination. 1614 61

The aim of the study is presentation the usefulness of CT examination in evaluation of ruptured abdominal aortic aneurysms. Material comprises a group of six patients (two women and four men) aged 52-79 years, examined in the 2nd Department of Radiology, Medical University of Lublin between the year 1997 and 2002. In all patients US examination and CT was performed. USG was performed with a Hitachi EUB 410 apparatus. CT was performed with Somatom AR. T scanner by Siemens, with two matrixes, 512 x 512 and 320 x 320 pixels. High resolution reconstruction algorithm was used with the possibility of performing spatial reformations. Five- and 10 mm-axial sections were performed before and after administering of contrast agents. Delayed scans were performed to reveal extravasations of the contrast agent. In three cases axial sections and MPR reconstructions revealed the presence of the periaortic haematoma with active extravasation of the contrasted blood. The ruptured aneurysm in two cases was associated with extensive retroperitoneal haematoma. The periaortic haematoma extended along the wall of the aneurysm. In one case the haematoma was localized mainly in front of aorta. In one case of aneurysm of abdominal aorta and iliac arteries, the rupture or left iliac artery with large retroperitoneal haematoma in the pelvis and intensive extravasation of contrasted blood was seen. The US examination with Power Doppler and Duplex facilitate in three cases evaluation of aneurysm localization. The rupture of abdominal aortic aneurysm is life-threatening condition, in vast majority of cases resulting in patient's death. In cases of acute rupture the clinical symptoms and CT examination of stable patients are essential. In chronic rupture the early diagnosis is very important. The main role plays CT examination, which enables revealing of the aneurysm, precise evaluation of the leakage, retroperitoneal haematoma, vertebral destruction and dislocation of aorta and kidneys.
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PMID:Ruptured abdominal aortic aneurysm in computed tomography. 1614 98

The membrane proximal region (MPR, residues 649-683) and transmembrane domain (TMD, residues 684-705) of the gp41 subunit of HIV-1's envelope protein are highly conserved and are important in viral mucosal transmission, virus attachment and membrane fusion with target cells. Several structures of the trimeric membrane proximal external region (residues 662-683) of MPR have been reported at the atomic level; however, the atomic structure of the TMD still remains unknown. To elucidate the structure of both MPR and TMD, we expressed the region spanning both domains, MPR-TM (residues 649-705), in Escherichia coli as a fusion protein with maltose binding protein (MBP). MPR-TM was initially fused to the C-terminus of MBP via a 42 aa-long linker containing a TEV protease recognition site (MBP-linker-MPR-TM). Biophysical characterization indicated that the purified MBP-linker-MPR-TM protein was a monodisperse and stable candidate for crystallization. However, crystals of the MBP-linker-MPR-TM protein could not be obtained in extensive crystallization screens. It is possible that the 42 residue-long linker between MBP and MPR-TM was interfering with crystal formation. To test this hypothesis, the 42 residue-long linker was replaced with three alanine residues. The fusion protein, MBP-AAA-MPR-TM, was similarly purified and characterized. Significantly, both the MBP-linker-MPR-TM and MBP-AAA-MPR-TM proteins strongly interacted with broadly neutralizing monoclonal antibodies 2F5 and 4E10. With epitopes accessible to the broadly neutralizing antibodies, these MBP/MPR-TM recombinant proteins may be in immunologically relevant conformations that mimic a pre-hairpin intermediate of gp41.
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PMID:Biophysical Characterization of a Vaccine Candidate against HIV-1: The Transmembrane and Membrane Proximal Domains of HIV-1 gp41 as a Maltose Binding Protein Fusion. 2629 57