Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0162871 (
abdominal aortic aneurysm
)
8,664
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Esperamycin shows potent DNA cleavage activity in the presence of sulfhydryl-containing compounds such as glutathione and dithiothreitol. In the esperamycin-mediated DNA degradation, deoxythymidylic and
deoxycytidylic acid
residues at oligopyrimidine regions of 5'-CTC, TTC, and TTT sequences are preferred cleavage sites. The DNA binding of a typical A-T specific minor groove binder, netropsin or distamycin A, strongly inhibits the DNA cuttings at 5'-TTC, TTT, and
AAA
sequences.
...
PMID:Nucleotide specificity of DNA cleavage by esperamycin/calichemicin antitumor antibiotics. 3026 Mar 48
