Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162871 (abdominal aortic aneurysm)
 8,664 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 54-year-old man with an expanding abdominal aortic aneurysm was operated on with a straight aortic graft. A paraparesis ensued three days postoperatively. Possible causative mechanisms, including influence on spinal venous pressure and direct effects of extradurally injected local anesthetic, are discussed.
 ...
PMID:Abdominal aortic aneurysma with postoperative delayed paraparesis. Case report. 167 40

From October 1986 to March 1989, a total of 7 patients who had preoperative profound shock underwent surgical treatment at the National Taiwan University Hospital for a ruptured aorta or vena cava. All 7 patients were men. Their age ranged from 21 to 70 years with a mean of 45 years. Emergency operations were performed due to a ruptured abdominal aortic aneurysm in 2, a ruptured dissecting thoracic aneurysm in 1, a penetrating injury which transected the intrahepatic vena cava in 2, and blunt chest injury which resulted in acute traumatic aortic transection in 2. One of these 7 patients died of acute tubular necrosis, anoxic encephalopathy and secondary sepsis, in spite of successful restoration of circulation. Two patients had postoperative complications. One had a transient paraparesis after an aortic cross-clamp, and the other had a transient impairment of the hepatic function due to the penetrating hepatic injury and the hypoxic hepatic damage. All 6 survivors were restored to an excellent state of health and had minimal post-resuscitation sequelae. We emphasize the importance of aggressive surgical treatment for those patients with the threat of impending death due to massive hemorrhage from a ruptured great vessel.
 ...
PMID:Emergency surgery of patients with ruptured great vessels and profound shock. 197 58

Over a four and a half year period ten patients operated upon for thoraco-abdominal aortic aneurysm. One patient died, and another developed paraparesis. Review of the literature and the experience obtained by using an intraluminal aortic graft for the proximal anastomosis is presented. Reduction of aortic cross-clamping time is essential in reducing complications, of which paraparesis is the most common. The employment of an intraluminal prosthesis whenever possible seems advantageous in achieving this goal. Patients with thoraco-abdominal aortic aneurysms can be treated with an acceptably low mortality and morbidity.
 ...
PMID:[Thoracoabdominal aortic aneurysms. Treatment, complications and early results]. 774 Jun 41

Damage to the spinal cord in course of the treatment of diseases of the infrarenal aorta is a rare but calamitous complication. The reported incidence is about 0.2%. The neurological loss is usually complete flaccid paraplegia with high mortality and rare full or partial recovery. Between 1980 and 1991, 1070 reconstructive procedures of the infrarenal aorta were performed: 821 due to aneurysm (316 elective procedures [mortality 1.6%] and 505 emergency procedures [mortality 24.5%]) and 249 due to aorto-iliac occlusive disease. Damage to the spinal cord occurred in 2 patients (2/1070, 0.19%). One patient had incomplete paraparesis following repair of an unruptured abdominal aortic aneurysm with gradual return of all neurological symptoms to normal. The second patient developed complete paraplegia following repair of a ruptured infrarenal aneurysm. There war no recovery of the symptoms. The patient died from septicaemia 4 months later.
 ...
PMID:[Paraplegia, a catastrophic complication of interventions on the infrarenal aorta]. 822 51

A seventy one year-old woman, who had an arch and thoracoabdominal aortic aneurysm (type II according to Crawford classification) with ischemic heart disease, underwent a separate operation using the elephant trunk method. At first, she underwent the ascending aorta and arch replacement the with elephant trunk technique, and, underwent CABG simulutaneously utilizing the separate extra corporeal circulation and hypothermic circulatory arrest. The Chest and abdominal CT revealed the enlargement of abdominal aortic aneurysm 5 months after operation. The second operation was performed using Stoney's spiral opening method and the revasculization of spinal arteries (Th6, 7 and Th9) underwent the segmental aortic clamping to prevent spinal cord ischemia. Furthermore, the second operation was performed using selective perfusion to visceral arteries and F-F bypass for the prevention of visceral ischemia. Each flow rate by selective perfusion in major abdominal blanches was from 50 to 100 ml/min. Therefore, hepatorenal dysfunction and paraparesis did not occur after the second operation. It was suggested that the segmental aortic clamping and the selective perfusion to visceral arteries with F-F bypass may be effective to prevent the ischemia of the spinal cord and abdominal organs.
 ...
PMID:[Separate operation for extensive aneurysm (mega-aorta) complicated with ischemic heart disease]. 978 73

In mammalian cells, mitochondria provide energy from aerobic metabolism. They play an important regulatory role in apoptosis, produce and detoxify free radicals, and serve as a cellular calcium buffer. Neurodegenerative disorders involving mitochondria can be divided into those caused by oxidative phosphorylation (OXPHOS) abnormalities either due to mitochondrial DNA (mtDNA) abnormalities, e.g., chronic external ophthalmoplegia, or due to nuclear mutations of OXPHOS proteins, e.g., complex I and II associated with Leigh syndrome. There are diseases caused by nuclear genes encoding non-OXPHOS mitochondrial proteins, such as frataxin in Friedreich ataxia (which is likely to play an important role in mitochondrial-cytosolic iron cycling), paraplegin (possibly a mitochondrial ATP-dependent zinc metalloprotease of the AAA-ATPases in hereditary spastic paraparesis), and possibly Wilson disease protein (an abnormal copper transporting ATP-dependent P-type ATPase associated with Wilson disease). Huntingon disease is an example of diseases with OXPHOS defects associated with mutations of nuclear genes encoding non-mitochondrial proteins such as huntingtin. There are also disorders with evidence of mitochondrial involvement that cannot as yet be assigned. These include Parkinson disease (where a complex I defect is described and free radicals are generated from dopamine metabolism), amyotrophic lateral sclerosis, and Alzheimer disease, where there is evidence to suggest mitochondrial involvement perhaps secondary to other abnormalities.
 ...
PMID:Mitochondria and degenerative disorders. 1157 22

Sixty-five consecutive patients undergoing nonemergent repair of an abdominal aortic aneurysm (AAA) originating above the visceral and/or renal arteries were studied to determine operative results and identify factors influencing outcome of proximal AAA repair. Factors associated with postoperative morbidity were analyzed using multivariate analysis. There were no postoperative deaths, paraplegia/paraparesis, or symptomatic visceral ischemia. Proximal AAA repair can be accomplished with acceptable mortality. If renal artery bypass or reimplantation is anticipated, cold renal perfusion may protect against renal dysfunction. Postoperative pulmonary dysfunction can be reduced by avoiding radial division of the diaphragm.
 ...
PMID:Factors affecting outcome in proximal abdominal aortic aneurysm repair. 1166 33

Paraplegia or paraparesis secondary to spinal cord ischemia is an extremely rare complication after elective repair of abdominal aortic aneurysm. We report delayed paraparesis after endovascular abdominal aortic aneurysm repair in which one hypogastric artery was unintentionally occluded due to atheroembolism. A spinal catheter was immediately inserted after onset of paraplegia to promote cerebrospinal fluid drainage, which partially reversed the neurologic deficit. Our case underscores both the importance of the critical spinal collateral supply from the hypogastric artery and the role of spinal fluid drainage to maximize spinal cord perfusion in the setting of spinal cord ischemia.
 ...
PMID:Delayed neurologic deficit after endovascular abdominal aortic aneurysm repair. 1261 14

Hereditary spastic paraparesis (HSP) belongs to a group of genetically and clinically heterogeneous disorders characterised by progressive spasticity of the legs and hyperreflexia. A further clinical distinction is drawn between pure and complicated HSP depending on the presence of other neurological and non-neurological signs. HSP may be inherited either as autosomal dominant, recessive, or X-linked. Twenty-two loci have been identified and additional ones are envisaged. In autosomal dominant HSP, 11 loci (five genes) have been identified, the most prevalent of which is linked to chromosome 2p, coding for spastin, an ATPase belonging to the AAA family (acronym of 'ATPase associated with diverse cellular activities'). Spastin is a nuclear protein, present in neurons, but not in glial cells, and seems to be involved in microtubule dynamics. Nonsense and frameshift mutations result in a reduced amount of spastin.
 ...
PMID:[From gene to disease; spastin and hereditary spastic paraparesis]. 1497 10

Endovascular stent-grafting holds great potential as a minimally invasive alternative to open surgery for thoracic aortic aneurysm. Although there have been several commercially available stent graft systems applied to abdominal aortic aneurysm in the United States, Gore TAG is the only device that is approved by Food and Drug Association (FDA) for thoracic aortic aneurysm repair. Experience of endovascular aneurysm repair by our homemade system and TAG device which is crafted particularly for the thoracic aorta is reported. TAG was successfully delivered to the target region in 137 patients (98%). The aneurysm was successfully excluded by our homemade system in 258 patients (94%). The mortality rates of TAG and our homemade device groups were 2.1 and 3.6% respectively. Postoperative stroke incidence was 1.8% and was more frequent in patients with stent-graft deployed in the region between the landing zone map of Z3 and Z4. The rate of paraplegia/paraparesis with delayed onset was 2.8% in TAG group, and was almost similar in the homemade group (2.6%). The event-free rate of patients treated with stent-graft was low as compared to that of open surgery in 1 and 3 year follow-up period. Endovascular stent-grafting is feasible as one treatment option for thoracic aortic aneurysm. Selection of proper indications, development of the better device and technical improvement are keys to successful stent-grafting.
 ...
PMID:[Endovascular stent-graft repair for thoracic aortic aneurysm]. 1691 May 12


1 2 Next >>