Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0162871 (
abdominal aortic aneurysm
)
8,664
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Abdominal aortic aneurysm
(
AAA
) is a significant health problem in Western countries. The diameter of
AAA
is a surrogate marker of its growth rate that reflects the magnitude of the degenerative process in the vascular wall, although most AAAs show discontinuous growth patterns and alternate periods of stability and nongrowth with periods of acute expansion and occasionally ruptures. Thus, the identification of biomarkers of
AAA
in plasma could aid in the diagnosis, prognosis, and therapy of
AAA
progression. However, owing to the complex composition of plasma, depletion methods must be applied before the analytical approaches for detecting low-abundant plasma protein components. In the present work, we describe a proteomic study on
MARS
14-depleted plasma based on mass spectrometry (MS) which combines peptide labelling (isobaric tagging for relative and absolute quantification, iTRAQ) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). This quantitative approach revealed altered levels of several proteins related to the complement system in
AAA
patients.
...
PMID:Unraveling biomarkers of abdominal aortic aneurisms by iTRAQ analysis of depleted plasma. 2358 91
