Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162871 (abdominal aortic aneurysm)
 8,664 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A comparative proteomics analysis was performed to identify the molecular response of a rice cultivar (Oryza sative cv. 'IRRI71331') with high phosphorous (P) uptake efficiency to low P stress. The hydroponically grown rice plants were provided with two levels of P (0.5 mg x L(-1) and 10 mg x L(-1)) supplied in quarter strength Kimura solution, and the root total proteins extracted on the 3rd and 6th day of treatments were separated by two-dimensional gel electrophoresis (2-DE). Comparing with the control (10 mg x L(-1) of P), a total of 29 protein spots under low P stress (0.5 mg x L(-1)) showed differences in their relative abundance, among which, 17 were higher, 11 were lower, and 1 was novel on the 3rd day, and 8 were induced, 19 were suppressed, 1 was disappeared, and 1 had no obvious change on the 6th day. Ten differentially expressed protein spots were identified by MALDI-TOF/MS, and searched in protein databases. According to the putative functions, the identified proteins were classified into four groups, i.e., signal transduction (glycine-rich RNA-binding protein, phosphate starvation response regulator-like), gene expression (putative pre-mRNA splicing factor, putative AAA-metalloprotease), metabolism (adenylosuccinate lyase, serpin, S-adenosylmethionine synthetase, MYB transcription factor-like protein), and ion transport (cation-transporting ATPase, sarcoplasmic reticulum protein). The identified proteins were involved in various physiological responses to enhance stress resistance, such as signal recognition and transduction, RNA cleavage, degradation of denatured protein, and ion transportation and cellular ion balance. The serine protease inhibitor and S-adenosylmethionine synthetase and the MYB transcription factor-like protein, which were the key proteins associated with P deficiency--tolerance of other species, were affected by the same stress for rice. The results indicated that the tolerance to low P stress was controlled by a complex signal transduction and metabolism regulation network in rice root system.
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PMID:[Differential protein analysis on the root response of rice with high phosphorous uptake efficiency to low phosphorous stress]. 2144 14

Posttranscriptional regulation of gene expression contributes to many developmental transitions. Previously, we found that the AAA chaperone Valosin-Containing Protein (VCP) regulates ecdysone-dependent dendrite pruning of Drosophila class IV dendritic arborization (c4da) neurons via an effect on RNA metabolism. In a search for RNA binding proteins associated with VCP, we identified the spliceosome-associated protein Mfap1, a component of the tri-snRNP complex. Mfap1 is a nucleolar protein in neurons and its levels are regulated by VCP. Mfap1 binds to VCP and TDP-43, a disease-associated RNA-binding protein. via distinct regions in its N- and C-terminal halfs. Similar to vcp mutations, Mfap1 overexpression causes c4da neuron dendrite pruning defects and mislocalization of TDP-43 in these cells, but genetic analyses show that Mfap1 is not a crucial VCP target during dendrite pruning. Finally, rescue experiments with a lethal mfap1 mutant show that the VCP binding region is not essential for Mfap1 function, but may act to increase its stability or activity.
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PMID:The spliceosome-associated protein Mfap1 binds to VCP in Drosophila. 2883 87