Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162871 (abdominal aortic aneurysm)
 8,664 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A unique case of a Chinese boy with Wiskott-Aldrich syndrome (WAS) associated with Takayasu's arteritis is reported. He had eczema, epistaxis and recurrent infections since early infancy and was found to have thrombocytopenia, negative delayed-type skin hypersensitivity, low T cell number and impaired lymphocyte proliferation to phytohaemagglutinin and concanavalin A. He had high normal serum immunoglobulin (Ig)G and IgA with low IgM and isohaemagglutinin. He presented with hypertensive encephalopathy at 5.5 years of age and an aortogram demonstrated abdominal aortic aneurysm with bilateral stenosis of renal arteries resulting in renovascular hypertension. His hypertension was difficult to control medically and autotransplant of his kidneys to the iliac arteries was performed, but he died in the immediate postoperative period. The relationship between immunodeficiency and collagen-vascular disease was discussed.
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PMID:Takayasu's arteritis associated with Wiskott-Aldrich syndrome. 135 86

The role of surgical therapy for Takayasu arteritis remains controversial. From 1973-1991, 23 patients with Takayasu arteritis have been treated at the University of Southern California. Twelve patients have required 17 arterial reconstructions for symptomatic complications of arterial disease refractory to medical therapy. Indications for operation have included renovascular hypertension (7), extremity ischemia (5), cerebrovascular insufficiency (2), dilated ascended aorta with aortic insufficiency (1), thoracic aortic aneurysm (1), and abdominal aortic aneurysm (1). Long-term clinical follow-up has demonstrated uniform symptomatic improvement. Fifteen of seventeen arterial reconstructions are still patent. Surgical treatment of symptomatic Takayasu arteritis is highly effective. Excellent long-term graft patency can be expected following arterial reconstruction.
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PMID:Surgical treatment of Takayasu arteritis. 136 Sep 62

Takayasu's arteritis is an inflammatory arteriopathy that often progresses to obliteration of multiple large arteries. Variable results have been reported after medical and surgical management. Twenty female patients with Takayasu's arteritis were treated from 1973 to 1989. Eleven (55%) patients had hypertension. Upper or lower extremity ischemia was present in 12 (60%) patients and cerebrovascular insufficiency in seven (35%). Nine patients initially managed with corticosteroids had no improvement in signs or symptoms of arterial insufficiency. Eleven patients had 16 vascular procedures for the following indications: renovascular hypertension (6), extremity ischemia (5), cerebrovascular insufficiency (2), dilation ascending aorta with aortic insufficiency (1), thoracic aortic aneurysm (1), abdominal aortic aneurysm (1). Procedures included aortorenal bypass (5), carotid-subclavian, axillary, or brachial bypass (4), aorto-carotid bypass (2), aneurysm resection (2), supra-celiac aorto-femoral bypass (1), ascending aorta/aortic valve replacement (1), and nephrectomy (1). Clinical improvement occurred in all patients. There were no operative deaths. All are alive at a mean follow-up of 5.75 years (6 months to 16 years). Revision of the initial reconstruction has been required for recurrent renovascular hypertension in one patient and extremity ischemia in another. The other nine patients remain symptomatically improved. Symptomatic Takayasu's arteritis frequently requires arterial reconstruction. Symptomatic improvement and excellent long-term graft patency can be expected after arterial reconstruction.
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PMID:Surgical procedures in the management of Takayasu's arteritis. 197 28

Two cases of "Inflammatory" aneurysm of the abdominal aorta and a review of this type of lesion were presented. The incidence of inflammatory aneurysm of the abdominal aorta in the literature is 2.5 to 15%, but there were no detail reports concerning with this in Japan. The pathogenesis is not clear, but it is evident both macroscopically and microscopically that the inflammatory aneurysms are different from athelosclerotic ones. They are characterized by perivascular peel of inflammatory fibrous tissue. It is possible that this type of aneurysms are merely a variant of Takayasu's disease. Until recently, the diagnosis of this type of aneurysm has not been made before surgery. The symptom of abdominal pain, weight loss, elevated ESR in a patient with abdominal aortic aneurysm are highly suggestive an inflammatory aneurysm. Characteristics of CT scan lead to more frequent preoperative diagnosis of inflammatory aneurysms of the aorta. It reveals a thickened often calcified aortic wall surrounded by a soft tissue mantle. Dynamic scanning shows an enhancing perianeurysnal mass. Graft replacement in these patients is often difficult and associated with increase in morbidity and mortality. At surgery, no attempt should be made to mobilize adjacent viscela in order to avoid injury. Arterial control should be obtained with as little as possible dissection. Some reports refer to successful steroid therapy resolving the inflammatory process and alleviating symptoms. Further research may resolve the treatment of choice for this type of lesion and optimize the timing of surgery.
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PMID:[Surgical treatment of "inflammatory" aneurysms of the abdominal aorta]. 332 Jul 39

The case of a 48-year-old man with an aneurysm of the inferior mesenteric artery is described. This aneurysm was associated with extensive vascular disease characterized by multiple sites of stenosis and occlusion in addition to an upper abdominal aortic aneurysm. Repair of both aneurysms and reconstruction of the left renal artery and inferior mesenteric artery, which supplied all splanchnic circulation, were performed. The aetiology of the disease was thought to involve Takayasu's arteritis.
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PMID:Aneurysm of the inferior mesenteric artery. 791 23

Since the incidence of inflammatory arterial disease has been higher in Japan, its surgical treatment has been one of the main themes of vascular surgery from its beginning in this country. Buerger disease has been the main cause of chronic occlusive arterial disease before the middle of 1970s. and many patients suffered from intractable ischemic leg ulcer with severe pain. Reconstructive surgery, however, has been so much limited that number of the candidates for bypass surgery were around 10% of the patients, because of distal nature of the disease. We have developed a new technique in distal bypass surgery named as Esmarch's rubber bandage method, which was intended to minimize surgical injury to the host artery, and the results of its application to Buerger disease is very encouraging, and we have confirmed that this technique enables a bypass to the collateral arteries and muscular branches in place of the diseased tibio-peroneal artery. We expect this technique will clear a new avenue to surgical treatment of Buerger disease with limb threatening ischemia. In Takayasu's arteritis, the carotid reconstruction was popular between the late 1950s and 1960s and, at the same time atypical coarctation, renovascular hypertension, and aneurysm, along with their combined lesion became the objects of vascular surgery. This expansion of surgical indication contributed to the improvement of the prognosis and rehabilitation of the patients. Long term function of the reconstruction has been also confirmed. On the other hand, several problems emerged with the widespread application of vascular reconstruction which were peculiar to the disease state. Among them, the most important problems were neurological complications due to sudden increase in the intracranial blood pressure after carotid reconstruction, and anastomotic aneurysm as the delayed complication affecting eventual outcome which are inherent to the inflammation and extensive destruction of the medial component in this disease. A new method to prevent the postoperative neurological complications is discussed in this report. To improve the long term survival, meticulous observation of postoperative course is essential in Takayasu's arteritis. Recently, abdominal aortic aneurysms showing the peculiar gross appearance and clinical presentation have become the subject of discussion as inflammatory abdominal aortic aneurysm because of remarkable thickening of the aneurysmal wall and a severe inflammatory change, and some difficulties of its surgical treatment have been stressed in the most of the reports. The recent researches offered the conclusion that etiology of the aneurysm is not inflammation, but inflammatory reaction during formation of atherosclerotic aneurysm.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Surgical treatment of intractable vasculitis syndromes--with special reference to Buerger disease, Takayasu arteritis, and so-called inflammatory abdominal aortic aneurysm]. 793 11

We compared the results of Tl-201 myocardial SPECT of patients with arteriosclerosis obliterans (ASO), abdominal aortic aneurysm (AAA), and Takayasu arteritis (TA), so that coronary artery disease could be evaluated in them. Twenty-three patients (ASO, 9; AAA, 8; TA, 6) had Tl-201 myocardial SPECT with stress testing, and SPECT data was assessed qualitatively and quantitatively. Qualitative analysis showed that myocardial perfusion was decreased most in patients with ASO, followed by patients with AAA, and was minimally decreased in patients with TA. Quantitative analysis indicated that segmental uptake was significantly less in four segments in ASO compared with TA, less in two segments in AAA compared with TA, and less in two segments in ASO compared with AAA. Thus patients with ASO and AAA were found to have a marked abnormality in Tl-201 myocardial SPECT, indicating that this procedure should be performed in these patients. In patients with TA, however, because of minimal abnormality in myocardial perfusion, the role of SPECT is limited.
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PMID:Tl-201 myocardial SPECT in patients with systemic arterial diseases. 985 96

Reports of true abdominal aortic aneurysms (AAAS), especially those due to severe inflammation, in patients with systemic lupus erythematosus (SLE) are very few in number. However, we had the experience of surgically treating a recurrent AAA due to severe inflammation found in a patient with SLE. The recurrence took place after an earlier operation for an infrarenal AAA and involved the left renal artery. In both situations, the previous infrarenal aaa and the recurrence, the aneurysms demonstrated more rapid growth and more irregularities in shape. Etiology of the AAA might be a combination of Takayasu's arteritis and SLE because the two entities appeared to have overlapped.
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PMID:Surgical treatment of recurrent abdominal aortic aneurysm in a patient with systemic lupus erythematosus. 1087 27

Takayasu arteritis, Buerger's diseases, temporal arteritis, vascular Behcet disease and inflammatory abdominal aortic aneurysm are classified in Japan as intractable vasculitides involving mainly large vessels, because their etiologies are not yet elucidated and, therefore, treatments for them were not yet established. Recent experimental and vascular biological studies, however, have focussed on the roles of virus infection in vasa vasorum (vasa vasoritis) and on the subsequent inflammatory vascular changes through HLA and/or other autoimmune mechanisms. Several studies including ours have demonstrated that these vascular inflammatory changes progress from the adventitial side to the intimal side of the vessel, finally complicating atherosclerotic changes in the intima. These vascular inflammatory changes are also recognized during progression of atherosclerosis and these observations strongly suggest that inflammation is a serious risk factor of atherosclerosis.
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PMID:Vasa vasoritis, vasculitis and atherosclerosis. 1098 Mar 30

A 54-year-old woman, who underwent descendo-abdominal aortic bypass grafting for atypical aortic coarctation complicated with Takayasu's arteritis 37 years previously, was referred to our hospital for treatment of a pseudoaneurysm due to rupture of the graft. Preoperative computed tomography scan also demonstrated an abdominal aortic aneurysm. First, an endovascular stent-graft repair of the pseudoaneurysm was performed, then the abdominal aortic aneurysm was repaired with the aid of cardiopulmonary bypass. Proper surgical planning was important to treat this rare development accompanied by aberrant circulation.
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PMID:Successful repair of graft failure and abdominal aortic aneurysm following thoraco-abdominal bypass for atypical aortic coarctation. 1499 81


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