Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162871 (abdominal aortic aneurysm)
 8,664 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Autolysed antigen-extracted allogeneic bone (AAA bone) was used to bridge a large osteoperiosteal gap in the diaphysis of the radius of 50 rabbits. Periodic observations of the graft were made clinically, radiologically and histologically every week up to fourteen weeks. The continuity of the radius was evaluated macroscopically and histologically. The AAA bones were progressively resorbed and replaced by the new bone. The bone remodelled to the mature tubular bone and did not undergo absorption during the experimental period. The AAA bone proceeded to be an osteoinductive and osteoconductive material. There were no appreciable histologic signs of immune or foreign body reaction.
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PMID:Autolysed antigen-extracted allogeneic bone for repair of diaphyseal bone defects in rabbits. 228 84

Three procedures to obtain bone inductive implants were tested heterotopically in 3-month-old allogeneic rats: 1) antigen-extracted HCl-decalcified at 4 degrees C, autolysed implant (AAA bone); 2) HCl-decalcified implant at 4 degrees C; 3) HCl-decalcified implant at room temperature. Each type of implant was either deep-frozen at -35 degrees C for at least 2 months or immediately freeze-dried. The bone inductive capacity of the differently HCl-decalcified cortical bone implant was evaluated at 2 months by isotopic strontium incorporation and by ash-weight measurements. Bone HCl-decalcification alone, either at 4 degrees C or at room temperature, gave a higher new bone yield than the freeze-dried AAA bone. The type or short-term preservation technique had no effect on the osteoinductive capacity of either of the differently treated implants, AAA bone expected.
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PMID:The osteoinductive capacity of differently HCl-decalcified bone alloimplants. 390 62

Osteoinductive bone allografts (autolyzed, antigen-extracted, allogeneic bone; AAA bone) were implanted in 207 cases. The patients had plastic surgery procedures to improve their profiles and were followed up for a maximum of 72 months. Twenty-two patients had an asymmetric mandible corrected with AAA bone chips. In 14 cases AAA bone implants were used for genioplasties. Forehead defects were reconstructed in 20 patients using AAA bone. Hypoplasia of the midface was corrected in 88 cases by augmentations with AAA bone chips or powder. A total of 63 patients underwent rhinoplasties in which AAA bone chips were used to shape or erect the dorsum nasi. Patient follow-up and reoperations to remove the osteosynthesis material revealed that the AAA bone implants were remodeled in the patients' own bone within several months. Less than 3% of the AAA bone implants were lost due to local infections. Except for rhinoplasties, secondary resorption of the bone allografts was extremely low. However, in cases in which strong tension resulted from scar formation or from lack of soft tissue, considerable resorption was observed, especially when AAA bone was implanted in the nose (25% of the rhinoplasties). On the other hand, this biodynamic behavior protected the implants from soft tissue perforation. In summary, AAA bone implants represent a convenient alternative to bone autografts in recipient beds with strong regenerative capacity. Since they are remodeled into the patient's bone none of the late complications found with alloplastic implants need to be expected.
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PMID:[Interventions for improving the facial profile with osteoinductive bone implants]. 942 58

Functional, aesthetically perfect restoration of the face of patients suffering from a severely smashed facial skeleton requires exact centrifugal repositioning and miniplate osteosynthesis of all bony fragments. Nevertheless, the original height and form of the nose will not be restored with these means in some cases. Therefore, in 23 cases with shattered noses out of 487 midface-trauma patients in the years 1990-1995 the noses were onlay-grafted as the primary procedure in 9 cases via the coronal approach and as the secondary one when the metal plates were removed in 10 cases. A combination of primary and secondary procedures was done in 4 cases. Five times autogenous bone from outer calvarium was used and 22 times allogenic, conserved bone from organ donors (AAA bone). According to extent of the damage, mini-screws and/or mini-plates served to fixate the graft. In addition to the group of 13 patients in the years 1990-1993 with nasal bone grafts via the coronary approach, another group the same size with the same amount of trauma but without rhinoplasty was defined and compared to the first group. An aesthetic analysis was done by grading the results according to simple criteria from 0 to 6 points by the patient and by the examiner. Noses grafted via the coronary approach were evaluated as being significantly (P = 0.004, t-test for independent samples, SPSS) better (2.1 points on average +/- 1.1 SD) than conventionally treated noses (3.5 points on average +/- 0.8 SD).
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PMID:[Rhinoplasty using the coronal approach after extensive facial skull fractures]. 942 85

Autolyzed, antigen-extracted, allogeneic bone (AAA bone) is prepared from cortical bones of human organ donors. AAA bone possesses osteoinductive properties as it delivers BMPs from its bone matrix. Within a prospective study, 37 cranial defects were reconstructed using AAA bone implants over a period of more than 7 years. The patients were followed-up at standardized intervals. Roentgenographic assessments and bone scintigraphies revealed osseous integration and remodelling of the AAA bone implants. In one quarter of the cases re-entry was performed 10 to 18 months after the cranioplasty (removal of osteosynthesis material, recurrence of tumor). All nine AAA bone reconstructions showed bleeding surfaces and bony integrations. A bone biopsy was taken from the center of one of these AAA bone implants and this showed new bone formation originating from the surface of the implant. In one case an AAA bone implant was lost due to infection. This is noteworthy as in approximately one third of the cases the bone implants were in direct contact with the frontal sinus. The clinical results clearly emphasize the therapeutical benefit of AAA bone for cranioplasties. Large AAA bone chips from human skull bones facilitate the reconstruction of the skull's convexity, especially when sterolithography-based operation planning is performed.
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PMID:[Clinical application of osteoinductive implants in craniofacial surgery]. 965 16

In 63 patients, 82 elevations of the maxillary sinus were performed. As augmentation, materials autografts from the iliac crest (combined with alveolar ridge augmentations in 16 sinus lifts) were transplanted in 39 cases and osteoinductive, allogeneic bone powder (AAA bone (autolyzed, antigen-extracted, allogeneic bone): n = 8, DFDBA (demineralized freeze-dried bone allograft) and/or Grafton (demineralized bone matrix gel): n = 35) were used in 43 cases. Some 4-6 months after implantation, osteoinductive, allogeneic (demineralized) bone implants showed radio-opaque areas as an equivalent of bone formation. Histological examinations revealed that osteoinductive implants were completely transformed into patients' own bone tissue. The average augmentation height after autograft transplantations was 14 (+/- 3) mm in comparison with 9 (+/- 3) mm after allograft implantations. Histologically as well as radiologically no differences of the bone quality could be determined between the two augmentation materials. Endoscopic controls showed, in both groups, nonirritated mucous membranes. On an average 2 endosseous implants (Bone Lock or ITI-screw implants) were inserted into the augmentated maxillary sinus floors in both groups. No osseointegration was achieved in 4 out of 67 dental implants when bone autografts were used and in 2 out of 74 dental implants of the allogeneic bone group. Patients with bone autografts suffered from postoperative complaints on an average of 19 (+/- 9) days (without consideration of 2 patients with postoperative complaints persisting for more than 90 days). The average postoperative complaints of recipients of allogeneic bone implants continued for 3 (+/- 5) days. The 13 patients who underwent an ambulant sinus lift procedure with allogeneic bone powder were already symptom-free several hours after the operation. Under critical consideration of all investigated parameters, osteoinductive bone implants are preferable to iliac bone autografts for maxillary sinus augmentations in those cases in which no additional alveolar ridge augmentation is required.
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PMID:[Comparative studies of sinus floor elevation with autologous or allogeneic bone tissue]. 1041 84

Autolyzed, antigen-extracted, allogeneic bone (AAA bone) is prepared from cortical bones of human organ donors. AAA bone possesses osteoinductive properties as it delivers BMPs from its bone matrix. Within a prospective study, 37 cranial defects were reconstructed using AAA bone implants over a period of more than 7 years. The patients were followed-up at standardized intervals. Roentgenographic assessments and bone scintigraphies revealed osseous integration and remodelling of the AAA bone implants. In one quarter of the cases re-entry was performed 10 to 18 months after the cranioplasty (removal of osteosynthesis material, recurrence of tumor). All nine AAA bone reconstructions showed bleeding surfaces and bony integrations. A bone biopsy was taken from the center of one of these AAA bone implants and this showed new bone formation originating from the surface of the implant. In one case an AAA bone implant was lost due to infection. This is noteworthy as in approximately one third of the cases the bone implants were in direct contact with the frontal sinus. The clinical results clearly emphasize the therapeutical benefit of AAA bone for cranioplasties. Large AAA bone chips from human skull bones facilitate the reconstruction of the skull's convexity, especially when sterolithography-based operation planning is performed.
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PMID:[Clinical application of osteoinductive implants in craniofacial surgery]. 2352 10