Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162671 (MELAS)
 587 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
VARS2 protein 15.7
MELAS 15.3
MERRF 14.8
IOSCA 14.7
SANDO 14.4
MNGIE 14.3
NARP 14.1
POLG protein 13.7
LHON 13.3
ORNT2 12.9
EFG2 12.9
CARS2 12.6
MT-TK 12.6
VARS2 12.3
FOXRED1 12.3
MTND5 12.3
MT-ND3 12.2
HIBCH 12.0
DARS2 12.0
FPRL2 11.7
GTPBP3 11.6
Tim14 11.5
PDHC 11.4
NDUFAF2 11.3
RARS2 11.3
CADASIL 11.3
Caytaxin 11.1
CMT4A 11.1
PCWH 11.1
FBXL4 11.0
ornithine transporter 11.0
TL1A 10.7
dGK 10.7
NADH dehydrogenase subunit 3 10.6
TMEM70 10.6
MT-CO2 10.6
MTO1 10.6
RXRB 10.6
POLG 10.4
MT-ND5 10.3
TRMU 10.2
HADHB 10.2
ASNS 10.1
ALDH5A1 10.0
CMT2A 9.9
MT-ND6 9.9
Transcription factor E3 9.8
CHCHD2 9.8
ND5 9.8
Thrombin receptor 9.8
Humanin 9.8
NDUFV1 9.7
mitochondrial transcription termination factor 9.6
NADH-ubiquinone reductase 9.6
MT-ND4 9.6
Succinic dehydrogenase 9.6
AHS 9.6
COXIII 9.5
ATPase subunit 6 9.5
ATF5 9.4
ATPase6 9.4
FPRL1 9.4
PRCC 9.4
COL4A1 9.3
PDHA1 9.2
ATPase 6 9.2
TPK1 9.2
RRF 9.2
HHH 9.2
DNA polymerase gamma 9.1
thymidine kinase 2 9.1
ASK 8.9
HEMO 8.9
GDAP1 8.9
ND6 8.9
EA1 8.9
E1 alpha 8.9
OXPHOS 8.9
COL4A2 8.8
G4.5 8.8
more...
Disease
MELAS 15.7
MELAS 15.7
SCAE 15.3
IOSCA 14.9
MERRF 14.8
SANDO 14.4
MNGIE 14.3
Central deafness 14.1
DCMA 13.7
Chronic progressive external ophthalmoplegia 13.5
mitochondrial encephalomyopathy 13.5
MILS 13.2
CARASIL 12.8
mitochondrial myopathy 12.8
Auditory agnosia 12.3
Kearns-Sayre syndrome 12.0
skin pigmentation disorder 12.0
lactic acidosis 11.9
PCWH 11.7
CMT2K 11.7
Alpers 11.4
mitochondrial disease 11.3
CADASIL 11.3
Membranous lipodystrophy 11.3
Leber's hereditary optic neuropathy 11.3
Leigh syndrome 11.2
Russian spring-summer encephalitis 11.1
CMT4A 11.1
PDH deficiency 10.8
Complex I deficiency 10.8
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 10.6
Demyelinating Polyneuropathy 10.6
myoclonus epilepsy 10.3
Alternating hemiplegia of childhood 10.3
FXTAS 10.2
Pearson's syndrome 10.1
Giant axonal neuropathy 9.8
Oculodentodigital dysplasia 9.7
infectious encephalitis 9.6
Pelizaeus-Merzbacher 9.4
FRDA 9.4
NSHL 9.3
encephalopathy 9.2
marantic endocarditis 9.1
Wolfram syndrome 9.1
Kufs' disease 9.0
Jervell and Lange-Nielsen syndrome 8.9
Barth syndrome 8.8
lipoproteinemia 8.6
hemiplegic migraine 8.6
Familial hemiplegic migraine 8.5
MCAD deficiency 8.5
hyperornithinemia 8.5
CMTX 8.4
GAN 8.4
hearing disability 8.4
Reye 8.3
glutaric aciduria 8.3
Alexander disease 8.3
Fahr's disease 8.1
global aphasia 8.1
Inborn errors of metabolism 8.1
deafness 8.1
PMD 8.1
myopathy 8.0
Herpes simplex encephalitis 8.0
Refsum disease 8.0
idiopathic cardiomyopathy 7.9
schizophrenic psychosis 7.9
Deafness 7.8
vascular headache 7.8
dysfibrinogenemia 7.7
primary disorders 7.7
Friedreich's ataxia 7.7
bilateral cataracts 7.6
leukoencephalopathy 7.5
xanthomatosis 7.5
Pelizaeus-Merzbacher disease 7.5
Waardenburg syndrome 7.5
ornithine transcarbamylase deficiency 7.5
more...
Symptom
External ophthalmoplegia 11.9
Ataxic 10.6
visual hallucination 9.1
ophthalmoplegia 8.8
Neurologic symptoms 8.2
myoclonus 7.3
cerebellar ataxia 6.9
syncopal episodes 6.7
ataxia 6.7
Decreased activity 6.7
clumsiness 6.6
ketonuria 6.6
tonic-clonic seizure 6.4
partial seizure 6.3
hemiplegia 6.1
muscle cramps 5.9
neurological disability 5.9
dysarthria 5.8
dysesthesia 5.8
catatonia 5.6
weakness 5.6
hypotonia 5.5
headache 5.2
seizures 5.2
spasticity 5.1
incoordination 4.9
chorea 4.7
vomiting 4.7
myalgia 4.6
paresthesia 4.5
pallor 4.4
ENT 4.4
paraparesis 4.3
dystonia 4.3
tinnitus 4.0
nausea 3.5
constipation 3.4
numbness 3.4
hepatomegaly 3.2
paresis 3.2
sleepiness 3.1
vertigo 2.9
tremor 2.6
dizziness 2.5
fatigue 2.4
angina 2.4
erythema 2.0
anesthesia 2.0
chest pain 1.7
hypothermia 1.6
dyspnea 1.0
analgesia 0.9
collapse 0.9
abdominal pain 0.8
pain -2.3
Drug
Arginine hydrochloride 11.9
Sodium dichloroacetate 11.1
R-gene 8.1
Gastro 6.9
PFA 5.7
EPI 5.7
niacin 4.8
NADH 4.6
MDS 4.6
Fragment 4.5
AZT 4.3
Fluorescein 4.3
Growth hormone 4.2
AZT 4.2
Growth hormone 4.2
MRC 4.0
CSF 4.0
Glucagon 3.9
Fluorescein 3.9
ENT 3.7
CTX 3.3
CTX 3.2
ABC 2.6
ROS 2.5
citric acid 2.5
CTX 2.4
ascorbate 2.2
Asn 2.2
lysine 1.9
vitamin E 1.6
Dermatol -1.3
Cardiovasc -1.9
Enzyme
leucyl-tRNA synthetase 8.5
complex I 8.3
HVS 7.8
LasR 7.5
pyruvate dehydrogenase 7.3
branched-chain alpha-keto acid dehydrogenase 7.1
biotinidase 7.1
alpha-ketoglutarate dehydrogenase 7.0
pyruvate dehydrogenase 7.0
pyruvate dehydrogenase 7.0
thymidine phosphorylase 6.7
cytochrome oxidase 6.6
fumarase 6.6
succinate dehydrogenase 6.5
argininosuccinate synthetase 6.3
succinic dehydrogenase 6.0
NADH dehydrogenase 5.7
citrate synthase 5.6
acyl-CoA dehydrogenase 5.3
diaphorase 5.2
pyruvate carboxylase 5.2
CPT 5.2
aconitase 5.0
glutamate decarboxylase 4.6
phosphoglycerate kinase 4.6
ATP synthase 4.5
CPR 4.4
diaphorase 4.3
acetyl-CoA carboxylase 4.2
thyroid peroxidase 4.1
CPT 4.1
CPT 4.0
NADPH-diaphorase 3.8
creatine kinase 3.5
ceruloplasmin 3.4
phosphorylase 3.3
phosphoinositide 3-kinase 3.2
endonuclease 3.1
cholinesterase 3.1
DNA polymerase 2.7
AMP-activated protein kinase 2.1
acetylcholinesterase 1.9
superoxide dismutase 1.9
NO synthase 1.8
RNase 1.7
calcineurin 1.7
RNase 1.6
ATPase 1.3
glutathione peroxidase 1.3
catalase 1.0
thrombin 0.7
caspase-3 0.6
mitogen-activated protein kinase 0.2
Compound
4-oxobutanoic acid 9.1
ASK 8.8
CoQ 8.0
coenzyme Q10 7.8
MSL 7.4
Edaravone 7.4
D-glucuronate 7.3
CIT 7.1
Coenzyme Q10 7.1
Fumarate 7.0
Valproic acid 6.7
MPT 6.7
DETA 6.7
Deoxyribonucleic acid 6.5
leucine 6.4
COX 6.4
N-acetylaspartate 6.4
EPC 6.3
Dichloroacetate 6.3
DCA 6.2
DCA 6.1
Taurine 6.1
Linezolid 6.1
Rotenone 6.1
Polypeptide 6.0
Pyruvate 5.8
ubiquinone 5.8
CAA 5.7
Xenon 5.7
Creatine 5.7
Argentine 5.3
SO3 5.2
phosphocreatine 5.0
Valproic acid 5.0
2-nonenal 5.0
uridine 4.9
L-carnitine 4.8
Cytochrome c 4.8
DOCA 4.8
COI 4.8
NADH 4.6
Glycogen 4.5
Leucine 4.5
tungsten 4.5
AAA 4.2
Guo 4.1
IMP 4.1
CPT 4.1
AZT 4.1
8-OHdG 4.1
nicotinamide 4.1
Rapamycin 4.0
Lactate 4.0
arginine 4.0
CPT 4.0
succinic acid 4.0
DNA 3.9
Glucagon 3.9
Tyrosine 3.8
lysine 3.7
Thrombin 3.7
ANA 3.6
ANA 3.6
Guo 3.5
NAD 3.4
ATP 3.4
MPTP 3.4
Neuronal 3.3
GSSG 3.3
nitric oxide 3.2
butyric acid 3.2
adenylate 3.1
butyric acid 3.1
PAS 3.1
His 3.1
NAD 3.0
butyric acid 3.0
DTPA 3.0
valine 2.9
2-oxoglutarate 2.9
more...