Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162671 (MELAS)
 587 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MELAS 455
tRNA 133
MERRF 108
Mol 47
Sep 45
MRI 43
cytochrome c oxidase 32
LHON 30
NARP 28
ATP 26
insulin 18
She 17
CADASIL 13
TL1A 12
ND5 11
cytochrome 11
NADH 10
pyruvate dehydrogenase complex 10
POLG 9
CSF 9
MNGIE 9
pyruvate dehydrogenase 8
axonal 8
ND1 7
X-linked 6
ND6 6
frataxin 6
SDH 6
PEO 6
OXPHOS 5
COX 5
osteosarcoma 5
NIDDM 5
ND4 5
nitric oxide synthase 4
DNA polymerase gamma 4
Polymerase 4
SANDO 4
ADP 4
MRS 4
more...
Disease
MELAS 587
MELAS 458
stroke 311
lactic acidosis 297
encephalopathy 203
mitochondrial myopathy 144
mitochondrial encephalomyopathy 112
MERRF 108
diabetes 89
mitochondrial disease 88
Leigh syndrome 62
epilepsy 58
myopathy 56
deafness 51
Kearns-Sayre syndrome 50
Leber's hereditary optic neuropathy 43
migraine 30
dementia 29
cardiomyopathy 27
Chronic progressive external ophthalmoplegia 25
hemiparesis 20
neuropathy 18
sensorineural hearing loss 17
myoclonus epilepsy 17
vascular disease 14
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 14
fits 14
status epilepticus 14
CADASIL 13
aphasia 11
type 2 diabetes 11
Alzheimer's disease 10
cognitive impairment 10
retinitis pigmentosa 10
Alpers 9
MNGIE 9
Parkinson's disease 9
hypertrophic cardiomyopathy 8
cerebral infarction 8
developmental delay 8
more...
Symptom
seizures 54
headache 39
weakness 33
ataxia 30
ophthalmoplegia 27
vomiting 15
myoclonus 12
anesthesia 8
cerebellar ataxia 8
fatigue 5
hypotonia 5
nausea 5
hemiplegia 5
dysarthria 4
spasticity 4
dystonia 3
myalgia 3
visual hallucination 3
angina 2
constipation 2
Ataxic 2
tremor 2
paresthesia 2
ENT 2
tonic-clonic seizure 2
sleepiness 2
tinnitus 2
chest pain 1
chorea 1
numbness 1
syncopal episodes 1
erythema 1
paraparesis 1
Neurologic symptoms 1
vertigo 1
ketonuria 1
abdominal pain 1
neurological disability 1
dysesthesia 1
External ophthalmoplegia 1
more...
Drug
NADH 10
CSF 9
lysine 4
ascorbate 2
niacin 2
ENT 2
EPI 2
Dermatol 2
ROS 2
Gastro 2
MDS 1
vitamin E 1
MRC 1
R-gene 1
Arginine hydrochloride 1
Fluorescein 1
citric acid 1
Growth hormone 1
ABC 1
AZT 1
Asn 1
AZT 1
Growth hormone 1
CTX 1
Glucagon 1
PFA 1
Cardiovasc 1
CTX 1
Fragment 1
Fluorescein 1
CTX 1
Sodium dichloroacetate 1
Enzyme
complex I 52
pyruvate dehydrogenase 16
cytochrome oxidase 16
succinate dehydrogenase 14
pyruvate dehydrogenase 8
pyruvate dehydrogenase 8
superoxide dismutase 4
citrate synthase 4
creatine kinase 4
diaphorase 4
LasR 3
CPT 3
alpha-ketoglutarate dehydrogenase 3
ATP synthase 3
endonuclease 3
ATPase 3
succinic dehydrogenase 2
acetylcholinesterase 2
fumarase 2
NADH dehydrogenase 2
mitogen-activated protein kinase 2
catalase 2
CPR 2
thymidine phosphorylase 2
DNA polymerase 2
cholinesterase 2
leucyl-tRNA synthetase 2
thyroid peroxidase 1
branched-chain alpha-keto acid dehydrogenase 1
phosphoinositide 3-kinase 1
diaphorase 1
glutathione peroxidase 1
RNase 1
glutamate decarboxylase 1
thrombin 1
CPT 1
ceruloplasmin 1
caspase-3 1
pyruvate carboxylase 1
argininosuccinate synthetase 1
more...
Compound
DNA 227
leucine 97
Dec 55
arginine 28
oxygen 26
Clin 26
ATP 26
glucose 21
lysine 20
nitric oxide 17
His 12
NADH 10
coenzyme Q10 10
calcium 9
sodium 9
uridine 7
CIT 7
CoQ 6
glutamate 6
ubiquinone 6
COX 5
nicotinamide 5
N-acetylaspartate 5
ammonium 5
alanine 5
ADP 4
NAD 4
NAD 4
creatinine 4
phosphorus 4
ADP 4
H2O2 4
ADP 4
threonine 3
hydrogen 3
Coenzyme Q10 3
nitrogen 3
phosphocreatine 3
urea 3
tungsten 3
more...