Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162671 (MELAS)
 587 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
VARS2 protein 15.7
MELAS 15.3
MERRF 14.8
IOSCA 14.7
SANDO 14.4
MNGIE 14.3
NARP 14.1
POLG protein 13.7
LHON 13.3
EFG2 12.9
ORNT2 12.9
CARS2 12.6
MT-TK 12.6
MTND5 12.3
FOXRED1 12.3
VARS2 12.3
MT-ND3 12.2
HIBCH 12.0
DARS2 12.0
FPRL2 11.7
GTPBP3 11.6
Tim14 11.5
PDHC 11.4
NDUFAF2 11.3
RARS2 11.3
CADASIL 11.3
Caytaxin 11.1
PCWH 11.1
CMT4A 11.1
ornithine transporter 11.0
FBXL4 11.0
TL1A 10.7
dGK 10.7
NADH dehydrogenase subunit 3 10.6
TMEM70 10.6
MT-CO2 10.6
MTO1 10.6
RXRB 10.6
POLG 10.4
MT-ND5 10.3
TRMU 10.2
HADHB 10.2
ASNS 10.1
ALDH5A1 10.0
CMT2A 9.9
MT-ND6 9.9
CHCHD2 9.8
Transcription factor E3 9.8
ND5 9.8
Thrombin receptor 9.8
Humanin 9.8
NDUFV1 9.7
mitochondrial transcription termination factor 9.6
NADH-ubiquinone reductase 9.6
MT-ND4 9.6
AHS 9.6
Succinic dehydrogenase 9.6
COXIII 9.5
ATPase subunit 6 9.5
ATF5 9.4
ATPase6 9.4
FPRL1 9.4
PRCC 9.4
COL4A1 9.3
PDHA1 9.2
ATPase 6 9.2
RRF 9.2
HHH 9.2
TPK1 9.2
DNA polymerase gamma 9.1
thymidine kinase 2 9.1
ASK 8.9
HEMO 8.9
GDAP1 8.9
ND6 8.9
EA1 8.9
E1 alpha 8.9
OXPHOS 8.9
COL4A2 8.8
G4.5 8.8
ND1 8.8
WFS1 8.7
FRDA 8.7
TK2 8.7
leucyl-tRNA synthetase 8.6
SACS 8.5
NADH-ubiquinone oxidoreductase 8.5
argininosuccinate synthase 8.5
NADH dehydrogenase subunit 1 8.4
ND4 8.4
eIF-2B 8.3
SLC20A2 8.3
Barth syndrome 8.3
pyruvate dehydrogenase complex 8.3
SDH 8.1
tRNA 8.1
PMD 8.1
Pyruvate dehydrogenase 8.0
cytochrome c oxidase 8.0
complex I) 8.0
ND4L 8.0
CMT2 8.0
CPT II 7.9
frataxin 7.9
ND3 7.9
mtTFA 7.9
cathepsin A 7.8
P43 7.8
2-oxoglutarate dehydrogenase 7.8
IGFBP3 7.8
neurofibromatosis type 2 7.7
GAN 7.7
HLA-B51 7.7
MFN2 7.7
TCI 7.6
COII 7.5
mitofusin 2 7.5
ATP6 7.3
medium-chain acyl-CoA dehydrogenase 7.3
Islet-1 7.2
SCA1 7.2
Alport syndrome 7.2
GDF15 7.2
PDC 7.1
Cytochrome b 7.1
biotinidase 7.1
MLD 7.0
NCL 7.0
fumarate hydratase 7.0
plectin 6.9
NIDDM 6.9
AED 6.9
pyruvate dehydrogenase 6.8
TFE3 6.7
thymidine phosphorylase 6.7
PEO 6.6
carnitine palmitoyltransferase 6.5
ASL 6.5
fragile X mental retardation protein 6.5
COX1 6.5
COX 6.4
alpha-ketoglutarate dehydrogenase 6.4
mitochondrial transcription factor A 6.3
X-linked adrenoleukodystrophy 6.3
elongation factor G 6.3
IP1 6.3
PGD 6.3
Golgi protein 6.2
aniridia 6.2
fumarase 6.2
APH 6.2
N-acetylaspartate 6.1
ND2 6.1
TCS 6.1
PND 6.1
ALD 6.1
HAS 6.0
Fibroblast growth factor 21 6.0
cytochrome aa3 6.0
glucose transporter 4 5.9
AAG 5.8
lipoamide dehydrogenase 5.8
EF-Tu 5.8
NADH dehydrogenase 5.7
Axin 5.7
glutathione peroxidase 1 5.7
E2 protein 5.7
HSP60 5.7
Apaf-1 5.7
Cx32 5.7
intrinsic factor 5.6
Q10 5.6
IDDM 5.6
EPI 5.5
MRS 5.5
MRP 5.5
enigma 5.4
COX2 5.4
P100 5.3
GAD65 5.3
ATF4 5.3
MnSOD 5.3
ADC 5.3
platelet-derived 5.3
pyruvate carboxylase 5.3
citrate synthase 5.3
urocortin 5.2
phosphoglycerate kinase 5.1
aconitase 5.1
thyroid peroxidase 5.0
Growth hormone 5.0
ATP synthase 5.0
BTR 5.0
SIN 5.0
Hsp60 4.9
COI 4.9
ubiquinone 4.9
connexin 43 4.8
retinol-binding protein 4.8
Cytochrome c 4.8
cytochrome 4.8
MLC 4.8
MRI 4.8
HIF-1alpha 4.8
X-linked recessive 4.7
glutamate decarboxylase 4.7
HSP 4.7
DAF 4.7
XIAP 4.7
SWI 4.7
NADH 4.6
AGS 4.6
MDS 4.6
DR3 4.6
Polymerase 4.6
DDP 4.5
Dicer 4.5
inhibitor of apoptosis 4.4
CSF 4.4
GRP78 4.4
ENT 4.3
acetyl-CoA carboxylase 4.3
p13 4.3
B19 4.3
ERG 4.3
X-linked 4.3
sarcomeric 4.2
osteosarcoma 4.2
AAA 4.2
HCC 4.2
IMP 4.2
NAC 4.2
brain) 4.2
Rett syndrome 4.2
DR4 4.1
GHRH 4.1
CPT 4.1
flavoprotein 4.1
She 4.1
MRC 4.0
cystatin C 4.0
ECD 3.9
SCF 3.9
creatine kinase 3.9
ADHD 3.9
PGC 3.8
glutamic acid decarboxylase 3.8
strabismus 3.8
oxidoreductase 3.8
ceruloplasmin 3.7
cardiac muscle 3.5
P-selectin 3.4
NAD 3.4
ATP 3.4
endothelial nitric oxide synthase 3.3
CHOP 3.3
axonal 3.3
acetylcholine receptor 3.3
CTX 3.2
phosphoinositide 3-kinase 3.2
asymmetrical 3.2
cytochrome b 3.1
endonuclease 3.1
STAT3 3.1
LDL receptor 3.1
NAD+ 3.1
transcriptional activator 3.1
vascular cell adhesion molecule-1 3.0
glucose transporter 2.9
desmin 2.9
AMP-activated protein kinase 2.9
nitric oxide synthase 2.9
cytochrome c 2.8
HEK 2.8
antioxidant enzyme 2.8
calcineurin 2.7
RhoA 2.6
ABC 2.6
glucagon 2.6
unknown function 2.6
peroxisome proliferator-activated receptor 2.6
heat shock protein 2.5
ADP 2.5
insulin receptor 2.5
ROS 2.5
RNase 2.4
adiponectin 2.4
vascular endothelium 2.3
FDG 2.3
insulin 2.2
mTOR 2.1
Mol 2.0
chronic renal failure 2.0
GTPase 1.9
prothrombin 1.9
caspase-3 1.8
Met 1.6
amyloid precursor protein 1.6
polypeptide 1.6
transferrin 1.6
reserved 1.4
ACTH 1.4
SOD 1.4
kit 1.4
glutathione peroxidase 1.3
nodal 1.2
catalase 1.2
superoxide dismutase 1.1
threonine 1.1
reductase 1.0
growth hormone 0.9
ATPase 0.9
fibrinogen 0.8
Bcl-2 0.7
thrombin 0.7
olfactory 0.6
GSH 0.5
HLA 0.4
Sep 0.3
Pol 0.2
more...
Disease
MELAS 15.7
MELAS 15.7
SCAE 15.3
IOSCA 14.9
MERRF 14.8
SANDO 14.4
MNGIE 14.3
Central deafness 14.1
DCMA 13.7
Chronic progressive external ophthalmoplegia 13.5
mitochondrial encephalomyopathy 13.5
MILS 13.2
CARASIL 12.8
mitochondrial myopathy 12.8
Auditory agnosia 12.3
Kearns-Sayre syndrome 12.0
skin pigmentation disorder 12.0
lactic acidosis 11.9
PCWH 11.7
CMT2K 11.7
Alpers 11.4
mitochondrial disease 11.3
CADASIL 11.3
Membranous lipodystrophy 11.3
Leber's hereditary optic neuropathy 11.3
Leigh syndrome 11.2
Russian spring-summer encephalitis 11.1
CMT4A 11.1
PDH deficiency 10.8
Complex I deficiency 10.8
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 10.6
Demyelinating Polyneuropathy 10.6
myoclonus epilepsy 10.3
Alternating hemiplegia of childhood 10.3
FXTAS 10.2
Pearson's syndrome 10.1
Giant axonal neuropathy 9.8
Oculodentodigital dysplasia 9.7
infectious encephalitis 9.6
Pelizaeus-Merzbacher 9.4
FRDA 9.4
NSHL 9.3
encephalopathy 9.2
Wolfram syndrome 9.1
marantic endocarditis 9.1
Kufs' disease 9.0
Jervell and Lange-Nielsen syndrome 8.9
Barth syndrome 8.8
lipoproteinemia 8.6
hemiplegic migraine 8.6
Familial hemiplegic migraine 8.5
MCAD deficiency 8.5
hyperornithinemia 8.5
CMTX 8.4
GAN 8.4
hearing disability 8.4
Reye 8.3
glutaric aciduria 8.3
Alexander disease 8.3
Fahr's disease 8.1
global aphasia 8.1
Inborn errors of metabolism 8.1
deafness 8.1
PMD 8.1
myopathy 8.0
Herpes simplex encephalitis 8.0
Refsum disease 8.0
idiopathic cardiomyopathy 7.9
schizophrenic psychosis 7.9
Deafness 7.8
vascular headache 7.8
dysfibrinogenemia 7.7
primary disorders 7.7
Friedreich's ataxia 7.7
bilateral cataracts 7.6
leukoencephalopathy 7.5
xanthomatosis 7.5
Pelizaeus-Merzbacher disease 7.5
Waardenburg syndrome 7.5
ornithine transcarbamylase deficiency 7.5
Canavan 7.5
CLE 7.4
common migraine 7.4
optic atrophy 7.4
hypertrichosis 7.4
hemiparesis 7.3
dysphasia 7.2
SCA1 7.2
sensorineural hearing loss 7.1
Binswanger 7.1
hearing disorder 7.1
PDC 7.1
hereditary neuropathy 7.1
anal atresia 7.1
gastrointestinal dysfunction 6.9
enzyme deficiency 6.9
arteriopathy 6.9
encephalomalacia 6.9
stroke 6.8
neonatal asphyxia 6.8
agnosia 6.8
incontinentia pigmenti 6.7
mild mental retardation 6.7
retinitis pigmentosa 6.7
status epilepticus 6.7
Menkes 6.7
neuronal ceroid lipofuscinosis 6.7
cerebellar syndrome 6.7
mutism 6.6
migraine 6.6
Optic nerve 6.5
McArdle's disease 6.5
malignant hyperthermia 6.5
motor aphasia 6.5
paralytic ileus 6.5
brain atrophy 6.5
Focal segmental glomerulosclerosis 6.5
AEM 6.4
aphasia 6.4
Krabbe disease 6.4
Alport syndrome 6.4
moderate mental retardation 6.4
POEMS syndrome 6.3
apraxia 6.3
Gerstmann 6.3
NPS 6.2
microcytic anemia 6.2
ALD 6.2
cardiomyopathy 6.1
borreliosis 6.1
Wernicke's encephalopathy 6.1
dysplastic nevi 6.1
CLN3 6.1
AMN 6.1
focal epilepsy 6.1
Harada 6.0
Horton 6.0
Wilson's disease 6.0
congenital disorder 6.0
PND 6.0
generalized seizure 6.0
attention deficit disorder 6.0
congenital rubella 6.0
Reye's syndrome 5.9
cerebral infarction 5.9
vitamin E deficiency 5.9
diabetic ketoacidosis 5.9
hypertrophic cardiomyopathy 5.9
scotoma 5.9
leukodystrophy 5.9
homocystinuria 5.8
LMS 5.8
CAA 5.8
Wolff-Parkinson-White syndrome 5.8
delayed puberty 5.7
developmental delay 5.7
growth hormone deficiency 5.7
protein deficiency 5.7
EPI 5.6
congenital infection 5.6
epilepsy 5.6
PDS 5.6
myasthenia 5.6
Cockayne syndrome 5.5
megacolon 5.5
MRS 5.5
vascular disease 5.5
hypopituitarism 5.5
primary central nervous system lymphoma 5.5
Addison's disease 5.4
NF2 5.4
metachromatic leukodystrophy 5.4
neuropathy 5.4
CAA 5.4
Addison's disease 5.4
neurological disease 5.4
paranoia 5.4
G6PD deficiency 5.3
seborrheic dermatitis 5.3
retinopathy 5.3
prolapse 5.2
Charcot-Marie-Tooth disease 5.2
Hashimoto's thyroiditis 5.2
glomerulosclerosis 5.2
retinitis 5.2
DRS 5.1
gastrointestinal disease 5.1
Tay-Sachs disease 5.1
Fanconi syndrome 5.0
Rett syndrome 5.0
failure to thrive 5.0
vitiligo 5.0
dystocia 4.9
sensory neuropathy 4.9
right bundle branch block 4.9
Marfan syndrome 4.9
Fabry 4.8
Ehlers-Danlos syndrome 4.8
dementia 4.8
gestational diabetes mellitus 4.8
LCA 4.8
muscular atrophy 4.8
moyamoya 4.7
Autism spectrum disorder 4.7
DM1 4.7
MLC 4.7
ventricular dilatation 4.6
acute tubular necrosis 4.6
premature aging 4.6
ileus 4.6
fits 4.6
AGS 4.6
brain edema 4.6
aspiration pneumonia 4.6
intermittent claudication 4.5
glucose intolerance 4.5
glomerulopathy 4.5
endometritis 4.5
MDS 4.5
antiphospholipid syndrome 4.5
HSP 4.4
EMA 4.4
diplopia 4.4
complex partial seizures 4.4
CNS diseases 4.4
disorientation 4.4
peripheral neuropathy 4.4
mental retardation 4.4
telangiectasia 4.4
optic neuritis 4.3
hypoparathyroidism 4.3
blindness 4.3
degenerative disease 4.3
systemic disease 4.2
tetraplegia 4.2
muscular dystrophy 4.2
HCC 4.2
AAA 4.2
dilated cardiomyopathy 4.1
encephalitis 4.1
diabetes 4.1
heart block 4.1
mental retardation 4.1
phenylketonuria 4.1
hyperhomocysteinemia 4.1
hypogonadotropic hypogonadism 4.0
osteosarcoma 4.0
hyperthyroidism 4.0
Syndrome 3.9
meninges 3.9
arteriovenous malformation 3.9
cognitive impairment 3.9
nystagmus 3.9
hyperuricemia 3.9
polyneuropathy 3.8
coma 3.8
wasting 3.8
Fanconi 3.7
sudden infant death syndrome 3.7
hyperprolactinemia 3.7
acute renal failure 3.7
herpes 3.7
volvulus 3.7
Creutzfeldt-Jakob disease 3.7
varicella 3.6
transient ischemic attack 3.5
carpal tunnel syndrome 3.5
cerebral palsy 3.5
HCG 3.5
primary biliary cirrhosis 3.5
preeclampsia 3.5
metabolic disorder 3.4
renal cancer 3.4
SLE 3.4
atrioventricular block 3.4
leiomyoma 3.4
type 2 diabetes 3.4
myopia 3.4
trisomy 3.4
Pituitary 3.3
amnesia 3.3
tuberous sclerosis 3.3
cerebral ischemia 3.3
parvovirus 3.2
psychosis 3.2
sickle cell disease 3.2
retinal detachment 3.2
delirium 3.2
CTX 3.2
rubella 3.2
amyotrophic lateral sclerosis 3.1
ventricular septal defect 3.0
erectile dysfunction 3.0
Parkinson's disease 3.0
Pancreas 2.9
toxoplasmosis 2.9
prematurity 2.9
confusion 2.9
Pancreas 2.9
malabsorption 2.9
respiratory failure 2.9
hallucinations 2.8
aspergillosis 2.8
proteinuria 2.8
congestive heart failure 2.8
hypothyroidism 2.8
goiter 2.7
autoimmune disease 2.7
WT1 2.7
meningioma 2.7
peptic ulcer 2.7
diabetic retinopathy 2.7
Chagas 2.7
syphilis 2.7
scoliosis 2.7
abdominal aortic aneurysm 2.6
genetic disorder 2.6
ADHD 2.6
glioblastoma 2.6
renal insufficiency 2.5
more...
Symptom
External ophthalmoplegia 11.9
Ataxic 10.6
visual hallucination 9.1
ophthalmoplegia 8.8
Neurologic symptoms 8.2
myoclonus 7.3
cerebellar ataxia 6.9
syncopal episodes 6.7
ataxia 6.7
Decreased activity 6.7
clumsiness 6.6
ketonuria 6.6
tonic-clonic seizure 6.4
partial seizure 6.3
hemiplegia 6.1
muscle cramps 5.9
neurological disability 5.9
dysarthria 5.8
dysesthesia 5.8
catatonia 5.6
weakness 5.6
hypotonia 5.5
headache 5.2
seizures 5.2
spasticity 5.1
incoordination 4.9
chorea 4.7
vomiting 4.7
myalgia 4.6
paresthesia 4.5
pallor 4.4
ENT 4.4
paraparesis 4.3
dystonia 4.3
tinnitus 4.0
nausea 3.5
constipation 3.4
numbness 3.4
hepatomegaly 3.2
paresis 3.2
sleepiness 3.1
vertigo 2.9
tremor 2.6
dizziness 2.5
fatigue 2.4
angina 2.4
erythema 2.0
anesthesia 2.0
chest pain 1.7
hypothermia 1.6
dyspnea 1.0
analgesia 0.9
collapse 0.9
abdominal pain 0.8
pain -2.3
Drug
Arginine hydrochloride 11.9
Sodium dichloroacetate 11.1
R-gene 8.1
Gastro 6.9
PFA 5.7
EPI 5.7
niacin 4.8
NADH 4.6
MDS 4.6
Fragment 4.5
AZT 4.3
Fluorescein 4.3
Growth hormone 4.2
AZT 4.2
Growth hormone 4.2
MRC 4.0
CSF 4.0
Glucagon 3.9
Fluorescein 3.9
ENT 3.7
CTX 3.3
CTX 3.2
ABC 2.6
ROS 2.5
citric acid 2.5
CTX 2.4
ascorbate 2.2
Asn 2.2
lysine 1.9
vitamin E 1.6
Dermatol -1.3
Cardiovasc -1.9
Enzyme
leucyl-tRNA synthetase 8.5
complex I 8.3
HVS 7.8
LasR 7.5
pyruvate dehydrogenase 7.3
branched-chain alpha-keto acid dehydrogenase 7.1
biotinidase 7.1
alpha-ketoglutarate dehydrogenase 7.0
pyruvate dehydrogenase 7.0
pyruvate dehydrogenase 7.0
thymidine phosphorylase 6.7
cytochrome oxidase 6.6
fumarase 6.6
succinate dehydrogenase 6.5
argininosuccinate synthetase 6.3
succinic dehydrogenase 6.0
NADH dehydrogenase 5.7
citrate synthase 5.6
acyl-CoA dehydrogenase 5.3
diaphorase 5.2
pyruvate carboxylase 5.2
CPT 5.2
aconitase 5.0
glutamate decarboxylase 4.6
phosphoglycerate kinase 4.6
ATP synthase 4.5
CPR 4.4
diaphorase 4.3
acetyl-CoA carboxylase 4.2
thyroid peroxidase 4.1
CPT 4.1
CPT 4.0
NADPH-diaphorase 3.8
creatine kinase 3.5
ceruloplasmin 3.4
phosphorylase 3.3
phosphoinositide 3-kinase 3.2
endonuclease 3.1
cholinesterase 3.1
DNA polymerase 2.7
AMP-activated protein kinase 2.1
acetylcholinesterase 1.9
superoxide dismutase 1.9
NO synthase 1.8
RNase 1.7
calcineurin 1.7
RNase 1.6
ATPase 1.3
glutathione peroxidase 1.3
catalase 1.0
thrombin 0.7
caspase-3 0.6
mitogen-activated protein kinase 0.2
Compound
4-oxobutanoic acid 9.1
ASK 8.8
CoQ 8.0
coenzyme Q10 7.8
MSL 7.4
Edaravone 7.4
D-glucuronate 7.3
CIT 7.1
Coenzyme Q10 7.1
Fumarate 7.0
Valproic acid 6.7
MPT 6.7
DETA 6.7
Deoxyribonucleic acid 6.5
leucine 6.4
COX 6.4
N-acetylaspartate 6.4
EPC 6.3
Dichloroacetate 6.3
DCA 6.2
DCA 6.1
Taurine 6.1
Linezolid 6.1
Rotenone 6.1
Polypeptide 6.0
Pyruvate 5.8
ubiquinone 5.8
CAA 5.7
Xenon 5.7
Creatine 5.7
Argentine 5.3
SO3 5.2
phosphocreatine 5.0
Valproic acid 5.0
2-nonenal 5.0
uridine 4.9
L-carnitine 4.8
Cytochrome c 4.8
DOCA 4.8
COI 4.8
NADH 4.6
Glycogen 4.5
Leucine 4.5
tungsten 4.5
AAA 4.2
Guo 4.1
IMP 4.1
CPT 4.1
AZT 4.1
8-OHdG 4.1
nicotinamide 4.1
Rapamycin 4.0
Lactate 4.0
arginine 4.0
CPT 4.0
succinic acid 4.0
DNA 3.9
Glucagon 3.9
Tyrosine 3.8
lysine 3.7
Thrombin 3.7
ANA 3.6
ANA 3.6
Guo 3.5
NAD 3.4
ATP 3.4
MPTP 3.4
Neuronal 3.3
GSSG 3.3
nitric oxide 3.2
butyric acid 3.2
adenylate 3.1
butyric acid 3.1
PAS 3.1
His 3.1
NAD 3.0
butyric acid 3.0
DTPA 3.0
valine 2.9
2-oxoglutarate 2.9
H2O2 2.8
dUTP 2.8
TSH 2.8
Diabetol 2.7
L-DOPA 2.6
ADP 2.5
ADP 2.5
Panam 2.5
CTX 2.4
ADP 2.3
Diabetol 2.3
N-acetylcysteine 2.3
phosphorus 2.2
glutamate 2.2
hydroxide 2.1
ammonium 2.1
glutamine 2.0
Off 2.0
Cereb 2.0
alanine 1.9
oxygen 1.9
glucose 1.9
threonine 1.9
creatinine 1.9
CoA 1.8
chlorine 1.7
Gly 1.7
aldehyde 1.5
ACTH 1.5
urea 1.3
bromide 1.3
aldehyde 1.1
Phe 1.1
methionine 0.9
sodium 0.8
MTT 0.7
Asp 0.6
acetic acid 0.6
calcium 0.6
Dec 0.5
glycerol 0.4
GSH 0.4
GSH 0.4
NH2 0.2
nitrogen 0.0
Clin -0.1
hydrogen -0.3
Cardiol -0.5
phosphate -0.7
CO2 -0.7
copper -0.8
tyrosine -0.8
iron -1.4
ethanol -1.4