Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162671 (MELAS)
 587 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MELAS 455
tRNA 133
MERRF 108
Mol 47
Sep 45
MRI 43
cytochrome c oxidase 32
LHON 30
NARP 28
ATP 26
insulin 18
She 17
CADASIL 13
TL1A 12
cytochrome 11
ND5 11
NADH 10
pyruvate dehydrogenase complex 10
POLG 9
MNGIE 9
CSF 9
axonal 8
pyruvate dehydrogenase 8
ND1 7
X-linked 6
ND6 6
SDH 6
frataxin 6
PEO 6
COX 5
NIDDM 5
osteosarcoma 5
ND4 5
OXPHOS 5
polypeptide 4
N-acetylaspartate 4
NAD 4
nitric oxide synthase 4
SANDO 4
DNA polymerase gamma 4
ADP 4
Polymerase 4
DARS2 4
MRS 4
creatine kinase 4
IOSCA 4
COL4A1 3
NADH-ubiquinone reductase 3
AHS 3
ubiquinone 3
Pol 3
cytochrome c 3
endonuclease 3
WFS1 3
complex I) 3
caspase-3 3
ATP synthase 3
POLG protein 3
citrate synthase 3
glucagon 3
Humanin 3
carnitine palmitoyltransferase 2
asymmetrical 2
Growth hormone 2
FPRL1 2
platelet-derived 2
GDF15 2
Alport syndrome 2
COII 2
AED 2
AAG 2
Pyruvate dehydrogenase 2
ENT 2
NADH dehydrogenase 2
ALD 2
ATPase 2
Barth syndrome 2
neurofibromatosis type 2 2
cytochrome aa3 2
SWI 2
EPI 2
cardiac muscle 2
superoxide dismutase 2
ATPase 6 2
MT-ND3 2
catalase 2
thymidine phosphorylase 2
MT-TK 2
PDHC 2
PGD 2
leucyl-tRNA synthetase 2
IDDM 2
ASK 2
NADH-ubiquinone oxidoreductase 2
STAT3 2
enigma 2
ROS 2
oxidoreductase 2
IGFBP3 2
mTOR 2
NMR 2
E1 alpha 2
MnSOD 2
COI 2
ND3 2
2-oxoglutarate dehydrogenase 2
PDC 2
FPRL2 2
Q10 2
PCWH 1
strabismus 1
flavoprotein 1
Cytochrome c 1
TRMU 1
PND 1
adiponectin 1
ATPase6 1
ADC 1
Bcl-2 1
X-linked recessive 1
SIN 1
heat shock protein 1
collagen 1
Cx32 1
mitofusin 2 1
IMP 1
RRF 1
Islet-1 1
EF-Tu 1
PGC 1
CMT4A 1
HSP 1
prothrombin 1
TMEM70 1
TCI 1
ASL 1
AMP-activated protein kinase 1
desmin 1
P-selectin 1
p13 1
GAN 1
HAS 1
HIF-1alpha 1
unknown function 1
connexin 43 1
CHCHD2 1
GTPase 1
olfactory 1
mitochondrial transcription termination factor 1
growth hormone 1
Hsp60 1
chronic renal failure 1
ASNS 1
CPT II 1
HHH 1
reserved 1
HLA-B51 1
transcriptional activator 1
calcineurin 1
sarcomeric 1
XIAP 1
IP1 1
PMD 1
vascular endothelium 1
HCC 1
pyruvate carboxylase 1
biotinidase 1
P100 1
Succinic dehydrogenase 1
RNase 1
Dicer 1
MT-ND5 1
FDG 1
CTX 1
P43 1
mtTFA 1
FRDA 1
HSP60 1
BTR 1
fumarate hydratase 1
TFE3 1
ORNT2 1
glutamate decarboxylase 1
Tim14 1
ABC 1
PDHA1 1
glutamic acid decarboxylase 1
DAF 1
insulin receptor 1
AGS 1
HLA 1
COXIII 1
SCA1 1
urocortin 1
SOD 1
ECD 1
acetyl-CoA carboxylase 1
MLD 1
fragile X mental retardation protein 1
ATP6 1
GRP78 1
amyloid precursor protein 1
glucose transporter 4 1
thymidine kinase 2 1
COL4A2 1
DR3 1
Met 1
MT-CO2 1
G4.5 1
GSH 1
Golgi protein 1
thrombin 1
ATPase subunit 6 1
ADHD 1
albumin 1
MT-ND4 1
MLC 1
threonine 1
HEMO 1
AAA 1
TCS 1
Fibroblast growth factor 21 1
ACTH 1
argininosuccinate synthase 1
VARS2 protein 1
HADHB 1
vascular cell adhesion molecule-1 1
MT-ND6 1
ATF5 1
glutathione peroxidase 1
ND2 1
aconitase 1
cystatin C 1
TK2 1
Cytochrome b 1
PRCC 1
SCF 1
GDAP1 1
ceruloplasmin 1
DR4 1
ERG 1
intrinsic factor 1
endothelial nitric oxide synthase 1
cathepsin A 1
TPK1 1
VARS2 1
CPT 1
LDL receptor 1
APH 1
COX2 1
glucose transporter 1
Transcription factor E3 1
phosphoinositide 3-kinase 1
thyroid peroxidase 1
fibrinogen 1
MRP 1
elongation factor G 1
DDP 1
ornithine transporter 1
CHOP 1
RXRB 1
inhibitor of apoptosis 1
MTO1 1
CARS2 1
phosphoglycerate kinase 1
acetylcholine receptor 1
cytochrome b 1
MTND5 1
brain) 1
NAD+ 1
SACS 1
NAC 1
lipoamide dehydrogenase 1
ND4L 1
E2 protein 1
Axin 1
retinol-binding protein 1
fused 1
FBXL4 1
MRC 1
transferrin 1
hemoglobin 1
nodal 1
GAD65 1
FOXRED1 1
medium-chain acyl-CoA dehydrogenase 1
MFN2 1
fumarase 1
Caytaxin 1
RhoA 1
dGK 1
GTPBP3 1
kit 1
RARS2 1
antioxidant enzyme 1
aniridia 1
mitochondrial transcription factor A 1
ATF4 1
Apaf-1 1
glutathione peroxidase 1 1
CMT2 1
eIF-2B 1
COX1 1
EA1 1
HIBCH 1
MDS 1
NADH dehydrogenase subunit 1 1
NCL 1
plectin 1
Rett syndrome 1
ALDH5A1 1
EFG2 1
alpha-ketoglutarate dehydrogenase 1
B19 1
GHRH 1
Thrombin receptor 1
SLC20A2 1
HEK 1
NDUFAF2 1
NDUFV1 1
more...
Disease
MELAS 587
MELAS 458
stroke 311
lactic acidosis 297
encephalopathy 203
mitochondrial myopathy 144
mitochondrial encephalomyopathy 112
MERRF 108
diabetes 89
mitochondrial disease 88
Leigh syndrome 62
epilepsy 58
myopathy 56
deafness 51
Kearns-Sayre syndrome 50
Leber's hereditary optic neuropathy 43
migraine 30
dementia 29
cardiomyopathy 27
Chronic progressive external ophthalmoplegia 25
hemiparesis 20
neuropathy 18
sensorineural hearing loss 17
myoclonus epilepsy 17
vascular disease 14
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 14
status epilepticus 14
fits 14
CADASIL 13
type 2 diabetes 11
aphasia 11
retinitis pigmentosa 10
cognitive impairment 10
Alzheimer's disease 10
Parkinson's disease 9
Alpers 9
MNGIE 9
brain atrophy 8
Friedreich's ataxia 8
cerebral infarction 8
prolapse 8
hypertrophic cardiomyopathy 8
developmental delay 8
leukoencephalopathy 8
retinopathy 7
optic atrophy 7
neurological disease 7
mental retardation 6
ischemia 6
blindness 6
encephalitis 6
hypertension 6
glomerulosclerosis 5
osteosarcoma 5
psychosis 5
cancer 5
glucose intolerance 5
mental retardation 5
depression 5
hemiplegic migraine 4
renal disease 4
malignant hyperthermia 4
muscular atrophy 4
apraxia 4
SANDO 4
arteriopathy 4
MRS 4
peripheral neuropathy 4
Wolfram syndrome 4
IOSCA 4
coma 4
tumor 4
confusion 3
enzyme deficiency 3
congestive heart failure 3
amyotrophic lateral sclerosis 3
Syndrome 3
preeclampsia 3
SCAE 3
renal failure 3
Fabry 3
MILS 3
schizophrenia 3
proteinuria 3
heart failure 3
Hashimoto's thyroiditis 3
PDH deficiency 3
hyperthyroidism 3
hypertrichosis 3
ALD 3
CARASIL 3
multiple sclerosis 3
dilated cardiomyopathy 3
systemic disease 3
cerebral ischemia 3
gestational diabetes mellitus 3
autoimmune disease 3
atherosclerosis 3
autism 3
Wilson's disease 3
acute renal failure 3
hyperglycemia 3
diabetic ketoacidosis 3
cytomegalovirus 2
gastrointestinal disease 2
aggression 2
Marfan syndrome 2
neuronal ceroid lipofuscinosis 2
polyneuropathy 2
Menkes 2
Pelizaeus-Merzbacher disease 2
DM1 2
PDC 2
failure to thrive 2
glioblastoma 2
dysphasia 2
antiphospholipid syndrome 2
Krabbe disease 2
vasculitis 2
sepsis 2
EPI 2
Wolff-Parkinson-White syndrome 2
Rett syndrome 2
Deafness 2
agnosia 2
muscular dystrophy 2
wasting 2
mutism 2
growth hormone deficiency 2
mental illness 2
ileus 2
Complex I deficiency 2
scotoma 2
cerebral palsy 2
diplopia 2
glutaric aciduria 2
dehydration 2
renal cell carcinoma 2
mild mental retardation 2
Barth syndrome 2
Alexander disease 2
congenital disorder 2
vitiligo 2
sickle cell disease 2
hypopituitarism 2
idiopathic cardiomyopathy 2
Charcot-Marie-Tooth disease 2
Alport syndrome 2
Waardenburg syndrome 2
herpes 2
Refsum disease 2
hypothyroidism 2
varicella 2
nystagmus 2
focal epilepsy 2
type 1 diabetes 2
sepsis 2
hepatocellular carcinoma 2
brain edema 2
cataract 2
respiratory failure 2
NF2 2
primary biliary cirrhosis 1
heart block 1
diabetic retinopathy 1
homocystinuria 1
trisomy 1
Pituitary 1
carcinoma 1
skin pigmentation disorder 1
nephrotic syndrome 1
CAA 1
hereditary neuropathy 1
hypogonadotropic hypogonadism 1
xanthomatosis 1
AIDS 1
ventricular septal defect 1
hyperhomocysteinemia 1
CMT2K 1
AEM 1
Kufs' disease 1
Addison's disease 1
SLE 1
WT1 1
hearing disorder 1
PDS 1
borreliosis 1
encephalomalacia 1
Pearson's syndrome 1
complex partial seizures 1
FRDA 1
sudden infant death syndrome 1
dysphagia 1
Gerstmann 1
endocarditis 1
motor aphasia 1
common migraine 1
delayed puberty 1
SCA1 1
erectile dysfunction 1
ADHD 1
endometritis 1
Familial hemiplegic migraine 1
myocardial infarction 1
pulmonary edema 1
systemic lupus erythematosus 1
pneumonia 1
myopia 1
Alternating hemiplegia of childhood 1
syphilis 1
paralytic ileus 1
PMD 1
Herpes simplex encephalitis 1
paranoia 1
Optic nerve 1
dysplastic nevi 1
hyperprolactinemia 1
aspiration pneumonia 1
mole 1
primary central nervous system lymphoma 1
tumorigenesis 1
carcinogenesis 1
GSH 1
myasthenia 1
hyperornithinemia 1
bilateral cataracts 1
Harada 1
infectious encephalitis 1
carpal tunnel syndrome 1
MCAD deficiency 1
CLE 1
leukodystrophy 1
Pelizaeus-Merzbacher 1
mole 1
glomerulonephritis 1
intermittent claudication 1
ornithine transcarbamylase deficiency 1
AGS 1
pulmonary hypertension 1
Focal segmental glomerulosclerosis 1
gastrointestinal dysfunction 1
Down syndrome 1
meningioma 1
scoliosis 1
Fanconi 1
prematurity 1
G6PD deficiency 1
Fanconi syndrome 1
meningitis 1
NSHL 1
congenital infection 1
amnesia 1
vascular headache 1
DRS 1
parkinsonism 1
Membranous lipodystrophy 1
CMTX 1
CLN3 1
McArdle's disease 1
CNS diseases 1
microcytic anemia 1
MLC 1
abdominal aortic aneurysm 1
Giant axonal neuropathy 1
Addison's disease 1
cerebellar syndrome 1
rubella 1
goiter 1
optic neuritis 1
anal atresia 1
toxoplasmosis 1
amyloidosis 1
PCWH 1
disorientation 1
DCMA 1
Creutzfeldt-Jakob disease 1
metachromatic leukodystrophy 1
Reye's syndrome 1
liver cancer 1
Reye 1
AAA 1
primary disorders 1
incontinentia pigmenti 1
Chagas 1
tuberous sclerosis 1
transient ischemic attack 1
myelodysplastic syndrome 1
ventricular dilatation 1
congenital rubella 1
metabolic disorder 1
Inborn errors of metabolism 1
Auditory agnosia 1
neuroblastoma 1
dysplasia 1
hypoglycemia 1
hearing disability 1
delirium 1
Autism spectrum disorder 1
PND 1
megacolon 1
Fahr's disease 1
LMS 1
EMA 1
lipoproteinemia 1
global aphasia 1
dystocia 1
seborrheic dermatitis 1
Jervell and Lange-Nielsen syndrome 1
retinitis 1
Oculodentodigital dysplasia 1
dysfibrinogenemia 1
hypoparathyroidism 1
vitamin E deficiency 1
phenylketonuria 1
schizophrenic psychosis 1
HCG 1
malabsorption 1
moderate mental retardation 1
CMT4A 1
peptic ulcer 1
more...
Symptom
seizures 54
headache 39
weakness 33
ataxia 30
ophthalmoplegia 27
vomiting 15
myoclonus 12
cerebellar ataxia 8
anesthesia 8
fatigue 5
hypotonia 5
nausea 5
hemiplegia 5
dysarthria 4
spasticity 4
dystonia 3
visual hallucination 3
myalgia 3
angina 2
constipation 2
tremor 2
Ataxic 2
sleepiness 2
ENT 2
paresthesia 2
tonic-clonic seizure 2
tinnitus 2
chest pain 1
chorea 1
numbness 1
syncopal episodes 1
erythema 1
paraparesis 1
Decreased activity 1
Neurologic symptoms 1
ketonuria 1
incoordination 1
vertigo 1
dizziness 1
External ophthalmoplegia 1
abdominal pain 1
neurological disability 1
dysesthesia 1
pain 1
catatonia 1
dyspnea 1
clumsiness 1
analgesia 1
pallor 1
paresis 1
collapse 1
partial seizure 1
hepatomegaly 1
hypothermia 1
muscle cramps 1
Drug
NADH 10
CSF 9
lysine 4
ascorbate 2
niacin 2
ENT 2
EPI 2
Dermatol 2
ROS 2
Gastro 2
MDS 1
vitamin E 1
MRC 1
R-gene 1
Arginine hydrochloride 1
Fluorescein 1
citric acid 1
Growth hormone 1
ABC 1
AZT 1
Asn 1
AZT 1
Growth hormone 1
CTX 1
Glucagon 1
PFA 1
Cardiovasc 1
CTX 1
Fragment 1
Fluorescein 1
CTX 1
Sodium dichloroacetate 1
Enzyme
complex I 52
cytochrome oxidase 16
pyruvate dehydrogenase 16
succinate dehydrogenase 14
pyruvate dehydrogenase 8
pyruvate dehydrogenase 8
superoxide dismutase 4
citrate synthase 4
diaphorase 4
creatine kinase 4
LasR 3
CPT 3
alpha-ketoglutarate dehydrogenase 3
ATP synthase 3
endonuclease 3
ATPase 3
succinic dehydrogenase 2
acetylcholinesterase 2
fumarase 2
cholinesterase 2
mitogen-activated protein kinase 2
CPR 2
catalase 2
thymidine phosphorylase 2
NADH dehydrogenase 2
DNA polymerase 2
leucyl-tRNA synthetase 2
thyroid peroxidase 1
branched-chain alpha-keto acid dehydrogenase 1
phosphoinositide 3-kinase 1
diaphorase 1
glutathione peroxidase 1
RNase 1
glutamate decarboxylase 1
thrombin 1
CPT 1
ceruloplasmin 1
acyl-CoA dehydrogenase 1
caspase-3 1
NO synthase 1
pyruvate carboxylase 1
AMP-activated protein kinase 1
argininosuccinate synthetase 1
acetyl-CoA carboxylase 1
phosphorylase 1
aconitase 1
NADPH-diaphorase 1
RNase 1
phosphoglycerate kinase 1
HVS 1
biotinidase 1
CPT 1
calcineurin 1
Compound
DNA 227
leucine 97
Dec 55
arginine 28
Clin 26
ATP 26
oxygen 26
glucose 21
lysine 20
nitric oxide 17
His 12
coenzyme Q10 10
NADH 10
calcium 9
sodium 9
CIT 7
uridine 7
CoQ 6
glutamate 6
ubiquinone 6
COX 5
nicotinamide 5
ammonium 5
alanine 5
N-acetylaspartate 5
H2O2 4
ADP 4
ADP 4
phosphorus 4
ADP 4
NAD 4
creatinine 4
NAD 4
Coenzyme Q10 3
nitrogen 3
hydrogen 3
tungsten 3
Cardiol 3
urea 3
phosphocreatine 3
Taurine 3
threonine 3
bromide 2
COI 2
Neuronal 2
phosphate 2
ASK 2
Valproic acid 2
Lactate 2
Pyruvate 2
hydroxide 2
methionine 2
L-carnitine 2
Phe 2
valine 2
Valproic acid 2
TSH 2
Gly 2
glutamine 2
ANA 1
Linezolid 1
PAS 1
CO2 1
copper 1
8-OHdG 1
Xenon 1
aldehyde 1
EPC 1
butyric acid 1
DETA 1
ethanol 1
GSH 1
ANA 1
aldehyde 1
Dichloroacetate 1
MTT 1
acetic acid 1
SO3 1
GSSG 1
4-oxobutanoic acid 1
chlorine 1
MSL 1
Off 1
D-glucuronate 1
CTX 1
MPTP 1
Creatine 1
NH2 1
Argentine 1
GSH 1
MPT 1
Panam 1
succinic acid 1
Fumarate 1
2-oxoglutarate 1
DCA 1
DOCA 1
glycerol 1
IMP 1
Glycogen 1
Cereb 1
Diabetol 1
Polypeptide 1
CAA 1
Cytochrome c 1
Tyrosine 1
CoA 1
Rotenone 1
butyric acid 1
Glucagon 1
Leucine 1
CPT 1
Asp 1
Diabetol 1
adenylate 1
tyrosine 1
Rapamycin 1
Thrombin 1
2-nonenal 1
DTPA 1
L-DOPA 1
iron 1
AZT 1
Edaravone 1
butyric acid 1
AAA 1
CPT 1
dUTP 1
Guo 1
DCA 1
ACTH 1
Deoxyribonucleic acid 1
Guo 1
N-acetylcysteine 1