Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162671 (MELAS)
 587 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MELAS 455
tRNA 133
MERRF 108
Mol 47
Sep 45
MRI 43
cytochrome c oxidase 32
LHON 30
NARP 28
ATP 26
insulin 18
She 17
CADASIL 13
TL1A 12
ND5 11
cytochrome 11
NADH 10
pyruvate dehydrogenase complex 10
MNGIE 9
CSF 9
POLG 9
pyruvate dehydrogenase 8
axonal 8
ND1 7
X-linked 6
frataxin 6
SDH 6
ND6 6
PEO 6
NIDDM 5
COX 5
OXPHOS 5
ND4 5
osteosarcoma 5
Polymerase 4
N-acetylaspartate 4
polypeptide 4
ADP 4
SANDO 4
NAD 4
DNA polymerase gamma 4
MRS 4
nitric oxide synthase 4
IOSCA 4
DARS2 4
creatine kinase 4
AHS 3
Humanin 3
Pol 3
ATP synthase 3
complex I) 3
cytochrome c 3
caspase-3 3
ubiquinone 3
glucagon 3
NADH-ubiquinone reductase 3
endonuclease 3
POLG protein 3
citrate synthase 3
WFS1 3
COL4A1 3
Alport syndrome 2
Barth syndrome 2
oxidoreductase 2
ROS 2
IGFBP3 2
STAT3 2
Pyruvate dehydrogenase 2
NMR 2
ENT 2
FPRL1 2
platelet-derived 2
ATPase 6 2
AED 2
PDC 2
NADH dehydrogenase 2
ALD 2
neurofibromatosis type 2 2
IDDM 2
ND3 2
PGD 2
thymidine phosphorylase 2
SWI 2
carnitine palmitoyltransferase 2
superoxide dismutase 2
MT-ND3 2
COI 2
catalase 2
COII 2
GDF15 2
Growth hormone 2
mTOR 2
PDHC 2
AAG 2
MT-TK 2
ASK 2
asymmetrical 2
NADH-ubiquinone oxidoreductase 2
cardiac muscle 2
enigma 2
EPI 2
cytochrome aa3 2
E1 alpha 2
MnSOD 2
leucyl-tRNA synthetase 2
2-oxoglutarate dehydrogenase 2
ATPase 2
FPRL2 2
Q10 2
heat shock protein 1
strabismus 1
thyroid peroxidase 1
EF-Tu 1
CMT4A 1
RXRB 1
PND 1
prothrombin 1
TCI 1
ADC 1
AMP-activated protein kinase 1
Cx32 1
mitofusin 2 1
IMP 1
fused 1
Transcription factor E3 1
Islet-1 1
CHOP 1
inhibitor of apoptosis 1
acetylcholine receptor 1
GAN 1
NAD+ 1
unknown function 1
connexin 43 1
NAC 1
Axin 1
P-selectin 1
hemoglobin 1
GAD65 1
medium-chain acyl-CoA dehydrogenase 1
MFN2 1
kit 1
antioxidant enzyme 1
chronic renal failure 1
ASNS 1
aniridia 1
CMT2 1
plectin 1
ALDH5A1 1
pyruvate carboxylase 1
biotinidase 1
P100 1
Succinic dehydrogenase 1
CTX 1
MT-ND5 1
B19 1
HSP60 1
glutamate decarboxylase 1
Tim14 1
PDHA1 1
glutamic acid decarboxylase 1
more...
Disease
MELAS 587
MELAS 458
stroke 311
lactic acidosis 297
encephalopathy 203
mitochondrial myopathy 144
mitochondrial encephalomyopathy 112
MERRF 108
diabetes 89
mitochondrial disease 88
Leigh syndrome 62
epilepsy 58
myopathy 56
deafness 51
Kearns-Sayre syndrome 50
Leber's hereditary optic neuropathy 43
migraine 30
dementia 29
cardiomyopathy 27
Chronic progressive external ophthalmoplegia 25
hemiparesis 20
neuropathy 18
myoclonus epilepsy 17
sensorineural hearing loss 17
fits 14
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 14
vascular disease 14
status epilepticus 14
CADASIL 13
aphasia 11
type 2 diabetes 11
Alzheimer's disease 10
cognitive impairment 10
retinitis pigmentosa 10
Parkinson's disease 9
MNGIE 9
Alpers 9
developmental delay 8
Friedreich's ataxia 8
brain atrophy 8
leukoencephalopathy 8
cerebral infarction 8
hypertrophic cardiomyopathy 8
prolapse 8
optic atrophy 7
neurological disease 7
retinopathy 7
blindness 6
hypertension 6
encephalitis 6
mental retardation 6
ischemia 6
cancer 5
glucose intolerance 5
psychosis 5
glomerulosclerosis 5
mental retardation 5
osteosarcoma 5
depression 5
IOSCA 4
arteriopathy 4
apraxia 4
SANDO 4
muscular atrophy 4
peripheral neuropathy 4
Wolfram syndrome 4
tumor 4
renal disease 4
hemiplegic migraine 4
MRS 4
malignant hyperthermia 4
coma 4
confusion 3
MILS 3
PDH deficiency 3
CARASIL 3
Syndrome 3
dilated cardiomyopathy 3
renal failure 3
SCAE 3
congestive heart failure 3
multiple sclerosis 3
hyperthyroidism 3
gestational diabetes mellitus 3
hypertrichosis 3
schizophrenia 3
autism 3
proteinuria 3
atherosclerosis 3
Hashimoto's thyroiditis 3
Wilson's disease 3
acute renal failure 3
Fabry 3
preeclampsia 3
amyotrophic lateral sclerosis 3
enzyme deficiency 3
ALD 3
cerebral ischemia 3
heart failure 3
autoimmune disease 3
systemic disease 3
hyperglycemia 3
diabetic ketoacidosis 3
cytomegalovirus 2
Refsum disease 2
Alport syndrome 2
gastrointestinal disease 2
aggression 2
agnosia 2
hepatocellular carcinoma 2
growth hormone deficiency 2
Marfan syndrome 2
mental illness 2
neuronal ceroid lipofuscinosis 2
ileus 2
Pelizaeus-Merzbacher disease 2
polyneuropathy 2
respiratory failure 2
renal cell carcinoma 2
dehydration 2
brain edema 2
congenital disorder 2
Complex I deficiency 2
muscular dystrophy 2
mutism 2
failure to thrive 2
Menkes 2
Wolff-Parkinson-White syndrome 2
Barth syndrome 2
antiphospholipid syndrome 2
Krabbe disease 2
EPI 2
focal epilepsy 2
sepsis 2
herpes 2
Rett syndrome 2
Deafness 2
DM1 2
PDC 2
varicella 2
Waardenburg syndrome 2
Charcot-Marie-Tooth disease 2
idiopathic cardiomyopathy 2
diplopia 2
Alexander disease 2
mild mental retardation 2
vitiligo 2
scotoma 2
glutaric aciduria 2
sickle cell disease 2
cerebral palsy 2
wasting 2
vasculitis 2
dysphasia 2
hypopituitarism 2
glioblastoma 2
hypothyroidism 2
nystagmus 2
type 1 diabetes 2
sepsis 2
more...
Symptom
seizures 54
headache 39
weakness 33
ataxia 30
ophthalmoplegia 27
vomiting 15
myoclonus 12
cerebellar ataxia 8
anesthesia 8
fatigue 5
hypotonia 5
nausea 5
hemiplegia 5
dysarthria 4
spasticity 4
dystonia 3
visual hallucination 3
myalgia 3
angina 2
constipation 2
tremor 2
Ataxic 2
sleepiness 2
ENT 2
paresthesia 2
tonic-clonic seizure 2
tinnitus 2
chest pain 1
chorea 1
numbness 1
syncopal episodes 1
erythema 1
paraparesis 1
Decreased activity 1
Neurologic symptoms 1
ketonuria 1
incoordination 1
vertigo 1
dizziness 1
External ophthalmoplegia 1
abdominal pain 1
neurological disability 1
dysesthesia 1
pain 1
catatonia 1
dyspnea 1
clumsiness 1
analgesia 1
pallor 1
paresis 1
collapse 1
partial seizure 1
hepatomegaly 1
hypothermia 1
muscle cramps 1
Drug
NADH 10
CSF 9
lysine 4
ascorbate 2
niacin 2
ENT 2
EPI 2
Dermatol 2
ROS 2
Gastro 2
MDS 1
vitamin E 1
MRC 1
R-gene 1
Arginine hydrochloride 1
Fluorescein 1
citric acid 1
Growth hormone 1
ABC 1
AZT 1
Asn 1
AZT 1
Growth hormone 1
CTX 1
Glucagon 1
PFA 1
Cardiovasc 1
CTX 1
Fragment 1
Fluorescein 1
CTX 1
Sodium dichloroacetate 1
Enzyme
complex I 52
cytochrome oxidase 16
pyruvate dehydrogenase 16
succinate dehydrogenase 14
pyruvate dehydrogenase 8
pyruvate dehydrogenase 8
superoxide dismutase 4
citrate synthase 4
diaphorase 4
creatine kinase 4
LasR 3
CPT 3
alpha-ketoglutarate dehydrogenase 3
ATP synthase 3
endonuclease 3
ATPase 3
succinic dehydrogenase 2
acetylcholinesterase 2
fumarase 2
cholinesterase 2
mitogen-activated protein kinase 2
CPR 2
catalase 2
thymidine phosphorylase 2
NADH dehydrogenase 2
DNA polymerase 2
leucyl-tRNA synthetase 2
thyroid peroxidase 1
branched-chain alpha-keto acid dehydrogenase 1
phosphoinositide 3-kinase 1
diaphorase 1
glutathione peroxidase 1
RNase 1
glutamate decarboxylase 1
thrombin 1
CPT 1
ceruloplasmin 1
acyl-CoA dehydrogenase 1
caspase-3 1
NO synthase 1
pyruvate carboxylase 1
AMP-activated protein kinase 1
argininosuccinate synthetase 1
acetyl-CoA carboxylase 1
phosphorylase 1
aconitase 1
NADPH-diaphorase 1
RNase 1
phosphoglycerate kinase 1
HVS 1
biotinidase 1
CPT 1
calcineurin 1
Compound
DNA 227
leucine 97
Dec 55
arginine 28
Clin 26
ATP 26
oxygen 26
glucose 21
lysine 20
nitric oxide 17
His 12
coenzyme Q10 10
NADH 10
calcium 9
sodium 9
CIT 7
uridine 7
CoQ 6
glutamate 6
ubiquinone 6
COX 5
nicotinamide 5
ammonium 5
alanine 5
N-acetylaspartate 5
H2O2 4
ADP 4
ADP 4
phosphorus 4
ADP 4
NAD 4
creatinine 4
NAD 4
Coenzyme Q10 3
nitrogen 3
hydrogen 3
tungsten 3
Cardiol 3
urea 3
phosphocreatine 3
Taurine 3
threonine 3
bromide 2
COI 2
Neuronal 2
phosphate 2
ASK 2
Valproic acid 2
Lactate 2
Pyruvate 2
hydroxide 2
methionine 2
L-carnitine 2
Phe 2
valine 2
Valproic acid 2
TSH 2
Gly 2
glutamine 2
ANA 1
Linezolid 1
PAS 1
CO2 1
copper 1
8-OHdG 1
Xenon 1
aldehyde 1
EPC 1
butyric acid 1
DETA 1
ethanol 1
GSH 1
ANA 1
aldehyde 1
Dichloroacetate 1
MTT 1
acetic acid 1
SO3 1
GSSG 1
4-oxobutanoic acid 1
chlorine 1
MSL 1
Off 1
D-glucuronate 1
CTX 1
MPTP 1
Creatine 1
NH2 1
Argentine 1
GSH 1
MPT 1
Panam 1
succinic acid 1
Fumarate 1
2-oxoglutarate 1
DCA 1
DOCA 1
glycerol 1
IMP 1
Glycogen 1
Cereb 1
Diabetol 1
Polypeptide 1
CAA 1
Cytochrome c 1
Tyrosine 1
CoA 1
Rotenone 1
butyric acid 1
Glucagon 1
Leucine 1
CPT 1
Asp 1
Diabetol 1
adenylate 1
tyrosine 1
Rapamycin 1
Thrombin 1
2-nonenal 1
DTPA 1
L-DOPA 1
iron 1
AZT 1
Edaravone 1
butyric acid 1
AAA 1
CPT 1
dUTP 1
Guo 1
DCA 1
ACTH 1
Deoxyribonucleic acid 1
Guo 1
N-acetylcysteine 1