Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162473 (Frey)
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Human Gene/Protein
ARHA 12.0
Galactose-1-phosphate uridylyltransferase 11.8
NEDD8-specific protease 11.0
cerebellin 4 10.8
deleted in liver cancer 2 10.8
GCH1 protein 10.6
CBLN2 10.4
Rho guanine nucleotide exchange factor 10 10.4
fragile histidine triad protein 10.3
G protein-coupled receptor 35 9.9
galanin receptor type 2 9.7
Acid-sensing ion channel 3 9.6
CHAR 9.6
SNL 9.5
LAP4 9.3
ST8Sia VI 9.2
IL6 protein 9.0
N-acyl phosphatidylethanolamine phospholipase D 9.0
UNC5H2 9.0
SLC17A9 8.8
Delta(5)-3-ketosteroid isomerase 8.8
p32 protein 8.8
Calpain-2 8.8
5-HT5A 8.7
LPP1 8.7
GCPS 8.5
ARHGEF10 8.5
CYP4F22 8.4
NPH1 8.3
SLC9A6 8.2
BITE 8.1
ASIC3 8.0
PDE7A 8.0
T13 8.0
Cannabinoid receptor 1 8.0
NHE6 7.9
QRFP 7.9
cerebellin 7.9
Voltage-gated sodium channel 7.9
oncostatin M receptor 7.8
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Disease
Frey 13.6
Gustatory sweating 12.3
Generalized hyperhidrosis 12.3
Non-bacterial prostatitis 12.0
Chronic sialadenitis 11.3
Painful Bladder Syndrome 11.0
Bile duct stricture 11.0
Hypoglucagonemia 10.8
Primary focal hyperhidrosis 10.3
Goldscheider 10.3
Biliary stricture 10.2
CHAR 10.1
Neonatal anoxia 9.8
LI3 9.7
Vulvar vestibulitis 9.6
Colonic obstruction 9.6
Pancreatic ascites 9.5
IMD1 9.4
Ross syndrome 9.3
Lupus erythematosus profundus 8.8
alcoholic neuropathy 8.5
mononeuropathy 8.4
NINA 8.3
Sluder 8.0
causalgia 8.0
Diabetic neuropathy 7.9
Gender dysphoria 7.7
Warthin's tumor 7.6
Facial palsy 7.5
bone cancer 7.5
Autotomy 7.5
nerve lesion 7.4
diabetic neuropathy 7.4
megalocytosis 7.2
monoarthritis 7.2
autonomic disorder 7.1
Lumbar disc herniation 7.1
chronic pancreatitis 6.9
chronic pain 6.9
sialolithiasis 6.9
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Symptom
Abnormal sensation 12.0
Throbbing pain 12.0
Cutaneous hyperalgesia 12.0
Central post-stroke pain 10.8
Central pain syndrome 10.8
Pancreatic pain 10.8
Peripheral neuropathic pain 10.6
Incisional pain 10.3
Mechanical pain 10.1
Radiating pain 10.0
Chronic pelvic pain syndrome 9.7
Radicular pain 9.7
Inflammatory pain 9.7
Neuropathic pain 9.4
Burning pain 9.3
Visceral pain 9.3
Lower abdominal pain 9.1
Other pain 8.9
UTI symptoms 8.6
bladder pain 8.6
Grimace 8.5
Intractable pain 8.5
skin pain 8.3
sialectasis 8.1
Central pain 7.9
hyperesthesia 7.9
nerve pain 7.8
vestibulitis 7.5
orofacial pain 7.5
Cold intolerance 7.5
Motor dysfunction 7.2
Vulvodynia 7.1
localized edema 6.8
motor symptom 6.7
facial droop 6.6
loss of equilibrium 6.5
cancer pain 6.4
flushing 6.4
acute pain 6.3
dysesthesia 6.3
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Drug
Vedaprofen 10.8
Dizocilpine maleate 10.5
Ezlopitant 10.4
Elcatonin 9.8
Naropin 9.5
SNL 9.2
Nitecapone 9.1
Propentofylline 8.8
Camostat mesilate 8.8
Dipyrone 8.3
Gabapentin 8.2
Oxaliplatin 8.1
Duloxetine 8.1
Tramadol hydrochloride 8.0
Pregabalin 7.8
Parecoxib 7.8
Tapentadol 7.8
Perhexiline 7.7
Reboxetine 7.7
Flunixin 7.6
Pyridostigmine bromide 7.3
Pyridostigmine bromide 7.1
Cilnidipine 7.1
Domperidone 7.0
Ketorolac 7.0
Tramal 6.9
Clove 6.9
Marcaine 6.9
Compound 18 6.8
Ulinastatin 6.7
Proglumide 6.7
Celebrex 6.6
Tenoxicam 6.6
Vinpocetine 6.4
Monosodium glutamate 6.2
BOTOX 6.2
Bromelain 6.1
Salmon calcitonin 6.1
Ritanserin 6.1
TRM 6.0
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Enzyme
PFL activase 12.3
lysine 2,3-aminomutase 10.5
NS protease 9.6
aminopeptidase Y 9.1
aminopeptidase I 7.7
pyruvate formate-lyase 7.6
acetoacetate decarboxylase 7.6
ethanolamine ammonia-lyase 7.3
cycloartenol synthase 7.3
GD3 synthase 7.0
galactose-1-phosphate uridylyltransferase 6.9
diol dehydratase 6.5
4-epimerase 6.4
IOR 6.4
triose-phosphate isomerase 6.0
uridyltransferase 5.9
aminopeptidase P 5.8
TSA 5.3
phosphoglycerate dehydrogenase 5.3
neutral sphingomyelinase 5.2
15-lipoxygenase 5.0
dihydropteridine reductase 4.9
CPN 4.8
hydrogenase 4.6
cathepsin S 4.6
PKG 4.6
hydrogenase 4.6
phosphoribulokinase 4.6
cystathionine gamma-lyase 4.5
SPT 4.5
CNPase 4.5
leucine aminopeptidase 4.5
isopeptidase 4.4
tissue kallikrein 4.3
CPS 4.3
GTP cyclohydrolase I 4.2
tryptophan synthase 4.2
PDH 4.2
fatty acid desaturase 4.1
CaMKII 3.9
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Compound
Ginsenoside Rf 12.0
Isosakuranetin 11.3
Spicamycin 11.3
1,2,3,4-tetrafluorobenzene 11.0
Budlein A 10.4
Budlein A 10.1
4-methylglutamic acid 9.6
4-methylglutamic acid 9.6
L-365260 9.3
1,5-isoquinolinediol 9.1
N-phenylpropanamide 9.1
1,4-difluorobenzene 9.0
Dezocine 8.8
4-methylquinazoline 8.7
Tricaine 8.3
Resiniferatoxin 8.2
9(10H)-anthracenone 8.2
T13 8.0
1-methyl-1H-indole 7.9
Hydrocodone 7.9
Myricitrin 7.9
Benzamil 7.7
Bergenin 7.7
Liquiritigenin 7.6
Hypotaurine 7.6
CH3NO2 7.5
Allyl isothiocyanate 7.5
Erythrosin 7.4
9(10H)-anthracenone 7.4
Vincristine 7.3
Alfentanil 7.3
isovaline 7.3
Glycolaldehyde 7.2
Cromolyn 7.2
MPE 7.2
Oxycodone 7.2
Tramadol 7.2
Ketorolac 7.1
FMI 7.1
DR-1 7.1
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