Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162316 (iron deficiency anemia)
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Human Gene/Protein
ankyrin repeat domain 37 12.4
TMPRSS6 11.7
transmembrane protease, serine 6 11.4
matriptase-2 11.3
hemochromatosis type 2 11.0
DCYTB 10.4
G1 to S phase transition 1 10.4
COPZ1 9.9
DDX42 9.9
NAP5 9.2
CACNA2D3 9.1
hemojuvelin 9.1
Hepcidin 8.9
ARHGEF3 8.8
TfR 8.7
AD 1 8.6
transferrin receptor 2 8.6
ferritin 8.5
IDA 8.4
hereditary hemochromatosis 8.2
ferroportin 1 8.1
Ferritin 8.1
GST-1 7.9
MSPL 7.9
FPN1 7.9
HFE2 7.8
DMT1 7.8
hephaestin 7.8
SLC39A14 7.7
divalent metal transporter 1 7.7
APR-1 7.6
SLC11A2 7.6
transferrin receptor 7.6
pyrimidine 5'-nucleotidase 7.6
SLC39A4 7.4
DCT1 7.4
BMP6 7.4
tissue factor pathway inhibitor-2 7.3
mitochondrial ferritin 7.3
HAMP 7.3
Trf 7.2
GP1BA 7.2
duodenal cytochrome b 7.2
HBE1 7.1
LVV-hemorphin-7 7.1
transferrin 7.1
transferin 7.1
SPTB 7.1
HBA2 7.0
transcobalamin II 7.0
CCN6 7.0
melanin-concentrating hormone 7.0
ITF 7.0
nuclear factor of kappa light polypeptide gene enhancer 6.9
mercaptopyruvate sulfurtransferase 6.9
hemochromatosis 6.9
NDST1 6.8
GPIa 6.8
ferroportin1 6.8
HFE 6.7
matriptase 6.7
PLA2G4A 6.7
hemoglobin 6.7
TFPI-2 6.7
ALK3 6.6
HFE protein 6.6
tissue transglutaminase 6.6
ACVRL1 6.6
ER81 6.5
ZIP1 6.5
hydroxymethylglutaryl-CoA synthase 6.5
B-12 6.5
ANK1 6.4
PKLR 6.4
UPRT 6.4
Neuropeptide W 6.4
ZIP4 6.3
pyridoxal kinase 6.3
SLC40A1 6.3
Transferrin 6.3
more...
Disease
perverted appetite 13.0
iron deficiency anemia 13.0
Chronic iron deficiency anemia 13.0
vagabond's disease 13.0
Angioectasia 12.0
Bantu siderosis 12.0
Thrombosed haemorrhoids 12.0
Secondary autoimmune haemolytic anaemia 12.0
Iron deficiency without anemia 11.9
Plummer-Vinson syndrome 11.6
vitamin B12 deficiency anemia 11.2
folate deficiency anemia 11.1
Alkaline reflux esophagitis 11.0
Gastrointestinal vascular malformations 11.0
Nutritional anemia 11.0
Idiopathic pulmonary hemosiderosis 10.9
Hemorrhoidal bleeding 10.7
anemia of chronic disease 10.6
Gastric antral vascular ectasia 10.6
esophageal web 10.5
iron deficiency 10.3
Secondary hemochromatosis 10.0
Adult celiac disease 10.0
anaemia in pregnancy 10.0
Microcytic hypochromic anemia 10.0
disorders of iron metabolism 10.0
thalassemia trait 9.9
microcytic anemia 9.8
Red cell aplasia 9.6
Sports anemia 9.6
Secondary anemia 9.6
Uremic syndrome 9.6
Gastrointestinal angiodysplasia 9.6
hypochromic anemia 9.5
thalassemia minor 9.4
Anemia during pregnancy 9.3
nutritional disorder 9.2
Geophagia 9.1
Portal hypertensive gastropathy 9.1
MDS-U 9.0
duodenal polyp 9.0
glycinuria 9.0
Tracheopathia osteoplastica 8.9
Celiac crisis 8.9
necatoriasis 8.8
Lymphocytic gastritis 8.8
Heyde's syndrome 8.7
intestinal angiodysplasia 8.7
hereditary anemia 8.6
congenital anemia 8.6
Chronic anemia 8.5
Angiodysplasia 8.5
Alkaline reflux gastritis 8.5
vitamin B12 deficiency 8.3
pica 8.2
Cold urticaria 8.2
megaloblastic anemia 8.1
Choledochocele 8.1
fasciolopsiasis 8.1
angiodysplasia 8.1
polymenorrhea 8.1
hemosiderosis 8.0
internal hemorrhoids 8.0
Reactive thrombocytosis 8.0
Leiomyoblastoma 8.0
hereditary hemochromatosis 8.0
Factor XII deficiency 7.9
HHT2 7.9
sideroblastic anemia 7.9
Gastric carcinoid 7.9
hookworm 7.9
calorie deficiency 7.8
Subacute combined degeneration 7.8
anemia 7.8
gastroliths 7.8
chronic paranoid schizophrenia 7.8
glossitis 7.8
Hb SC disease 7.7
Brunner's gland hyperplasia 7.7
pernicious anemia 7.6
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Symptom
Drug withdrawal symptoms 12.0
koilonychia 10.0
intermenstrual pain 8.4
Watery diarrhea 7.9
localized abdominal pain 7.9
Functional constipation 7.1
Grimace 7.0
intestinal bleeding 7.0
menometrorrhagia 6.7
pallor 6.6
hypoproteinemia 6.6
dysosmia 6.5
giddiness 6.4
giddiness 6.4
glossodynia 6.2
clubbing 6.0
abdominal fullness 5.9
leg cramps 5.8
exertional chest pain 5.7
precordial pain 5.6
Flare 5.6
hemoptysis 5.5
catarrh 5.4
Gastrointestinal symptoms 5.4
chyluria 5.4
aphagia 5.4
asterixis 5.3
pedal edema 5.3
inanition 5.2
tenesmus 5.1
metamorphopsia 5.1
abdominal discomfort 5.1
epigastric pain 5.0
breath holding 4.9
lassitude 4.9
meningism 4.6
forgetfulness 4.6
abdominal pain 4.5
loss of taste 4.5
asthenia 4.5
bloating 4.3
heartburn 4.3
tingling 4.3
chronic constipation 4.3
hepatosplenomegaly 4.2
constipation 4.2
stomach pain 4.1
abdominal cramps 4.0
clumsiness 3.9
hyperemesis gravidarum 3.9
diarrhea 3.9
excessive sweating 3.9
shortness of breath 3.9
splenomegaly 3.8
pleuritic chest pain 3.8
persistent cough 3.8
thigh pain 3.6
fatigue 3.6
exertional dyspnea 3.6
anorexia 3.6
clonus 3.5
wheezing 3.4
arthralgia 3.4
dizziness 3.4
consciousness disturbance 3.3
vomiting 3.3
tachypnea 3.3
livedo 3.3
weakness 3.2
dysesthesia 3.1
lethargy 3.1
dry skin 3.0
apathy 3.0
acute abdomen 3.0
blurred vision 3.0
bone pain 3.0
hypersomnia 3.0
joint stiffness 3.0
colic 3.0
nausea 3.0
more...
Drug
Blutal 12.0
Venofer 10.6
Ferumoxytol 10.6
Iron dextran 10.3
Ferrum 10.3
Ferrlecit 10.0
Imferon 9.9
Ferrous sulfate 9.5
Rho(D) immune globulin 9.2
Calcium citrate 8.4
Folic Acid 8.1
Polydextrose 7.9
Ortho Tri-Cyclen 7.6
Beraprost 7.3
Treprostinil 6.6
Lanthanum carbonate 6.5
Intal 6.2
Giardiasis 6.1
Levonorgestrel 5.9
Pyridoxal phosphate 5.9
Sulphasalazine 5.8
Panitumumab 5.7
Encore 5.1
Fansidar 5.1
Vitamin B12 5.1
Fansidar 5.1
Cellulose acetate 5.0
Areca 4.9
ID2 4.9
Norplant 4.8
Vitamin A 4.8
Triad 4.8
Triad 4.6
Bosentan 4.3
Bosentan 4.3
Diclofenac sodium 4.3
MDS 4.2
FeCl3 4.2
DDAVP 4.1
DDAVP 4.1
ascorbate 4.0
Heme 4.0
pyridoxal phosphate 3.7
Depo-Provera 3.7
NBT 3.7
Riboflavin 3.4
CIA 3.4
Bayer 3.4
Norplant 3.4
Kenyan 3.3
Gastro 3.2
ALA 3.2
Cetuximab 3.1
Reserpine 3.1
Check 3.1
Omeprazole 3.0
PFA 3.0
Vitamin E 2.9
RFP 2.8
Vitamin B 2.7
niacin 2.7
Phenytoin 2.6
Prednisolone 2.5
ROC 2.4
Diurnal 2.3
Award 2.3
Bevacizumab 2.2
EE2 2.1
vitamin E 2.1
EPI 2.0
nitroglycerin 1.9
L-tyrosine 1.8
Ouabain 1.7
ENT 1.6
Growth hormone 1.5
Growth hormone 1.5
ADM 1.4
PTH 1.3
p75 1.1
MAP 1.1
more...
Enzyme
EC 3.1.2.3 11.4
inulin fructotransferase 8.6
inulin fructotransferase 8.3
matriptase 6.8
matriptase 6.4
pyridoxal kinase 6.3
DMT 5.7
transglutaminase 5.2
3-mercaptopyruvate sulfurtransferase 5.1
iodothyronine 5'-deiodinase 4.9
ferrochelatase 4.8
acetoacetyl-CoA thiolase 4.7
inulinase 4.7
enterokinase 4.6
thyroid peroxidase 4.6
inulinase 4.6
guanylate kinase 4.5
ceruloplasmin 4.4
succinyl-CoA synthetase 4.3
SCP 4.2
HMG-CoA synthase 4.1
paraoxonase 3.9
AOR 3.8
phytase 3.7
phytase 3.7
3-hydroxyacyl-CoA dehydrogenase 3.6
paraoxonase 3.6
GAS 3.1
SCS 3.0
ALA synthase 3.0
heme oxygenase 3.0
3-hydroxy-3-methylglutaryl-CoA reductase 2.9
21-hydroxylase 2.8
glutathione peroxidase 2.8
alpha-ketoglutarate dehydrogenase 2.7
PGM 2.6
urease 2.5
3-hydroxy-3-methylglutaryl coenzyme A reductase 2.5
glucocerebrosidase 2.5
thromboplastin 2.5
urease 2.5
glutathione reductase 2.4
PTA 2.3
aconitase 2.3
glycerol-3-phosphate dehydrogenase 2.2
glycerol-3-phosphate dehydrogenase 2.2
prolyl hydroxylase 2.2
prostaglandin synthetase 2.2
adenylate kinase 2.1
methylenetetrahydrofolate reductase 2.0
methylenetetrahydrofolate reductase 2.0
cytochrome oxidase 1.9
citrate synthase 1.9
carbonic anhydrase 1.8
superoxide dismutase 1.7
glucose-6-phosphate dehydrogenase 1.7
MDP 1.6
furin 1.4
catalase 1.2
phosphofructokinase 1.1
neutrophil elastase 1.0
APC 1.0
elastase 0.9
glutamine synthetase 0.7
adenosine deaminase 0.7
adenosine deaminase 0.7
pyruvate kinase 0.7
CPR 0.7
hexokinase 0.7
alkaline phosphatase 0.7
urokinase-type plasminogen activator 0.6
alanine aminotransferase 0.6
monoamine oxidase 0.6
chymotrypsin 0.6
diaphorase 0.5
glyceraldehyde-3-phosphate dehydrogenase 0.4
papain 0.3
ERK 0.3
aspartate aminotransferase 0.2
succinate dehydrogenase 0.0
more...
Compound
Ferrous sulfate 9.3
Navidrex 9.3
Zinc protoporphyrin 8.7
BTT 8.4
IDA 8.3
MCH 7.9
Ferric citrate 7.8
Nickel chloride 7.6
BNS 7.3
iron 7.0
MIDA 6.9
Hemoglobin 6.6
Parenteral 6.2
Levonorgestrel 6.2
IPC 6.2
Protoporphyrin IX 6.0
IPC 5.7
DMT 5.7
DMT 5.5
2,3-diphosphoglycerate 5.5
DBI 5.1
PBG 5.1
HBB 5.1
RBA 5.1
Cellobiose 5.0
Sudan I 5.0
Tocopherols 4.9
TCH 4.9
AAB 4.8
AAB 4.8
Vitamin A 4.8
methanesulfonic acid 4.5
methanesulfonic acid 4.5
methanesulfonic acid 4.5
methanesulfonic acid 4.5
VPM 4.5
methanesulfonic acid 4.5
retinol 4.4
Piroxicam 4.4
DPG 4.3
AEA 4.3
barium 4.3
Disodium cromoglycate 4.3
DFS 4.2
Tin 4.1
Xylose 4.1
Leucovorin 4.1
MEP 4.1
Busulfan 4.0
Heme 4.0
AME 4.0
PGA 4.0
H-3 4.0
MEP 3.9
Bantu 3.8
Phytic acid 3.8
DPG 3.8
Levofloxacin 3.8
Bilirubin 3.8
Hemin 3.7
Hemin 3.7
Hemin 3.7
Hemin 3.7
zinc 3.7
Fluo-3 3.7
TCE 3.7
Ascorbic acid 3.7
AEA 3.7
Malondialdehyde 3.7
DPT 3.7
Albendazole 3.7
delta-aminolevulinic acid 3.6
Hemin 3.6
NBT 3.6
1,1,1-trichloroethane 3.6
6-12 3.5
Inulin 3.5
SSD 3.4
ISDN 3.4
MPC 3.4
more...