Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0162316 (
iron deficiency anemia
)
3,806
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Recently, the iron and erythropoiesis-controlled
growth differentiation factor 15
(
GDF15
) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload. To access the diagnostic and pathogenic impact of
GDF15
in inflammatory anaemia the association of
GDF15
expression with serum iron parameters and hepcidin was studied in patients suffering from
iron deficiency anaemia
(
IDA
), anaemia of chronic disease (ACD) and ACD subjects with true iron deficiency (ACD/
IDA
).
GDF15
was significantly increased in both ACD and ACD/
IDA
, but not in
IDA
subjects as compared to controls. In contrast, hepcidin levels were significantly lower in
IDA
and ACD/
IDA
subjects than in ACD patients.
IDA
and ACD/
IDA
, but not ACD, showed an association between
GDF15
and soluble transferrin receptor, an indicator of iron requirement for erythropoiesis. However,
GDF15
did not correlate to hepcidin in either patient group. While
GDF15
levels were linked to the needs for erythropoiesis and iron homeostasis in
IDA
, the immunity-driven increase of
GDF15
may not primarily affect iron homeostasis and hepcidin expression. This indicates that other ACD-related factors may overcome the regulatory effects of
GDF15
on hepcidin expression during inflammation.
...
PMID:Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia. 1986 34
