Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0162316 (
iron deficiency anemia
)
3,806
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hepatic hepcidin synthesis is stimulated by inflammation but inhibited during
iron deficiency anemia
(
IDA
). In humans, the relative strength of these opposing signals on serum hepcidin and the net effect on iron absorption and systemic iron recycling is uncertain. In this prospective, 45-day study, in young women (n=46; age 18-49 years) with or without
IDA
, we compared iron and inflammation markers, serum hepcidin and erythrocyte iron incorporation from
57
Fe-labeled test meals, before and 8, 24 and 36 hours (h) after influenza/
DPT
vaccination as an acute inflammatory stimulus. Compared to baseline, at 24-36 h after vaccination: 1) interleukin-6 increased 2-3-fold in both groups (
P
<0.001); 2) serum hepcidin increased >2-fold in the non-anemic group (
P
<0.001), but did not significantly change in the
IDA
group; 3) serum iron decreased in the non-anemic group (
P
<0.05) but did not change in the
IDA
group; and 4) erythrocyte iron incorporation did not change in either of the two groups, but was approximately 2-fold higher in the
IDA
group both before and after vaccination (
P
<0.001). In this study, mild acute inflammation did not increase serum hepcidin in women with
IDA
, suggesting low iron status and erythropoietic drive offset the inflammatory stimulus on hepcidin expression. In non-anemic women, inflammation increased serum hepcidin and produced mild hypoferremia, but did not reduce dietary iron absorption, suggesting iron-recycling macrophages are more sensitive than the enterocyte to high serum hepcidin during inflammation. The study was registered as a prospective observational trial at
clinicaltrials.gov identifier: 02175888
The study was funded by the International Atomic Energy Agency.
...
PMID:The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women. 3115 85
