Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diffuse well-differentiated lymphocytic lymphoma (D-WDLL) and chronic lymphocytic lymphoma (CLL) represent closely related neoplasms which may have indolent courses. Dating back more than one century, reports of associated second primary malignancies continue to intrigue clinicians. A case of synchronous D-WDLL and gastric adenocarcinoma, presenting as splenomegaly and iron deficiency anemia, is presented. The case and literature are reviewed.
Am J Gastroenterol 1990 Dec
PMID:Synchronous diffuse well-differentiated lymphocytic lymphoma and gastric adenocarcinoma presenting as splenomegaly and iron deficiency anemia. 225 32

The measurement of erythrocyte protoporphyrin (EPP) has been used in screening infants for undue exposure to lead. The infants were from a high risk area, Al Jahra in Kuwait, and were selected from those attending the emergency department of Al Jahra District Hospital. Dried spots of blood on Guthrie filter paper were mailed to the Central Laboratory of the Children's Hospital in Buffalo, New York. Elevated EPP values (greater than 50 micrograms/dl) were present in 63 (66%) out of 96 tests. Forty-four of the infants with elevated values were investigated further: 16 had blood lead levels above 30 micrograms/dl (1.45 mmol/l) and 12 had evidence of iron deficiency anaemia. Five infants with blood lead levels above 80 micrograms/dl (3.9 mmol/l) needed urgent chelation and in addition an 8-month-old infant with the highest EPP value (478 micrograms/dl) died of acute lead encephalopathy. We conclude that lead poisoning is a serious problem in Al Jahra, Kuwait, and that a comprehensive programme for screening and health education are urgently needed to avoid the irreversible effects of lead toxicity.
Ann Trop Paediatr 1985 Dec
PMID:High incidence of lead poisoning revealed by erythrocyte protoporphyrin (EPP) screening in Arabian children. 241 70

Many biochemical tests evaluated in young adults are widely used in the elderly without further evaluation. This study, designed to assess the clinical use of transferrin and transferrin saturation in the diagnosis of iron deficiency anaemia in the elderly, illustrates how these tests have a lower specificity in this age group, limiting their clinical use. Reasons for the altered results are discussed. If resources are to be used effectively, the usefulness of many investigations in the elderly needs to be examined and suitable age-adjusted reference ranges produced.
Br J Clin Pract 1989 Dec
PMID:Diagnostic investigations in the elderly: the clinical usefulness of serum iron and transferrin measurements in the diagnosis of iron deficiency anaemia. An audit. 261 Nov 8

Cognitive function. There is reasonably good evidence that mental and motor developmental test scores are lower among infants with iron deficiency anemia. Although the research on cognitive function in iron deficient older children and adults is sparse and diverse, it suggests that there may be alterations in attentional processes associated with iron deficiency. Iron therapy has not yet been shown effective in completely correcting many of the observed disturbances. Although some aspects of cognitive function seem to change with iron therapy, lower developmental. I.Q., and achievement test scores have still been noted after treatment. The behavioral effects of iron-deficiency anemia may be due to changes in neurotransmission. However, the biochemical bases are not yet completely understood. Noncognitive disturbances. A variety of noncognitive alterations during infant developmental testing has also been observed, including failure to respond to test stimuli, short attention span, unhappiness, increased fearfulness, withdrawal from the examiner, and increased body tension. Exploratory analyses suggest that such behavioral abnormalities may account for poor developmental test performance in infants with iron deficiency anemia. These studies indicate the fruitfulness of examining noncognitive aspects of behavior such as affect, attention, and activity, in addition to specific cognitive processes. Activity and work capacity: There has been a steady accumulation of evidence that iron-deficiency anemia limits maximal physical performance, submaximal endurance, and spontaneous activity in the adult, resulting in diminished work productivity with attendant economic losses. The relative importance of central and peripheral mechanisms underlying these effects, the extent to which anemia or iron deficiency separate from anemia is responsible, and the counterpart in infants and children remain to be established. This essay has examined recent evidence from research on central nervous system biochemistry and from human studies that iron deficiency adversely affects behavior by impairing cognitive function, producing noncognitive disturbances, and limiting activity and work capacity. The body of research taken as a whole provides increasingly persuasive arguments for intensifying efforts to prevent and treat iron deficiency anemia.
Bull N Y Acad Med 1989 Dec
PMID:Iron and learning potential in childhood. 269 45

Blood, pH and bicarbonate were examined in 40 normal subjects and in 53 patients with anemia. Included were 28 patients with thalassemia, 18 with aplastic anemia and seven with iron deficiency anemia. Mean increases in pH of 0-0.04 and decreases in HCO3 of 2.3-3.5 mEq/L were observed. Changes were not significantly affected by the degree of erythropoiesis or by the severity of the anemia and were essentially the same in the three groups of patients studied. Typical changes of a mild, uncompensated alkalosis were also produced on four occasions in one transfused thalassemic patient.
Am J Med Sci 1987 Dec
PMID:A mild uncompensated alkalosis in anemia. 312 64

A 56-year-old woman with Osler-Weber-Rendu disease had longstanding iron deficiency anemia from recurrent melena. Since neither laser photocoagulation nor surgery were successful in stopping the increasing transfusion need, combined estrogen-progesterone therapy was started. Except for slight bleeding from a temporary ileostomy, the bleeding and need for transfusion terminated promptly. This experience confirms that estrogen-progesterone therapy may promote cessation of bleeding gastrointestinal telangiectasias and indicates the need for controlled investigations.
J Clin Gastroenterol 1988 Dec
PMID:Estrogen-progesterone treatment of Osler-Weber-Rendu disease. 326 45

Serum transferrin receptors were measured by a sandwich radioimmunoassay procedure in patients with iron deficiency anemia, autoimmune hemolytic anemia and aplastic anemia. The mean circulating transferrin receptor concentration of normal subjects and patients with iron deficiency anemia, autoimmune hemolytic anemia and aplastic anemia are 253 +/- 82 ng/mL, 730 +/- 391 ng/mL, 1,426 +/- 1,079 ng/mL, and 182 +/- 39 ng/mL, respectively. The values for those with iron deficiency anemia and autoimmune hemolytic anemia were significantly higher than that of normal controls and the values for those with aplastic anemia were lower than that of normal controls. After iron supplementation in iron deficiency anemia, the serum transferrin receptor values increased twofold over those of pretreatment values. This increase parallels an increase in peripheral reticulocytes. Therefore, the number of circulating transferrin receptors in anemic patients may reflect the level of bone marrow erythropoiesis and is a potentially useful new index for red cell production.
Blood 1987 Dec
PMID:Serum transferrin receptor as a new index of erythropoiesis. 367 19

The effects of the Steel Ring, the Copper V (VCu 200), and the Copper T (TCu 220c) were compared in terms of menstrual blood loss, serum ferritin, the incidence of menorrhagia, and anemia before and after insertion to evaluate the safety of these IUDs and to determine if any of them are appropriate for longterm use in Chinese women. 60 healthy women, 20-39 years, with regular menstrual periods, normal pelvic examination, who had used no oral contraceptives (OCs) for more than 1 year were recruited. Those who previously had used an IUD or had an abortion or parturition were admitted after at least 3 normal menses. Each subject was instructed in the method for complete collection of menstrual blood for 1 entire menstrual period. Menstrual blood loss was measured by alkaline hematin photometry and a Stomacher Lab-blender was used for extraction. The insertions of the IUDs were uneventful. After insertion, the mean blood loss for each group at all intervals was significantly higher than that of preinsertion, especially in the 1st postinsertion cycle. Thereafter, blood loss remained high or gradually decreased, but it did not return to the preinsertion levels even at the 24th postinsertion cycle. The differences were still significant, especially for the T group. The mean increase 25.4 ml (55.8%) for the Ring group, 32.3 ml (56.8%) for the V group, and 39.9 ml (82.2%) for the T group. The highest blood loss for the Ring group was 154 ml, for the V group 290.9 ml, and for the T group 211 ml. The incidence of menorrhagia of all IUDs was significantly increased in the 1st postinsertion cycle. Except for the Ring group, the differences were still significant even in the 24th postinsertion cycle. The mean value of serum ferritin for the Ring group was significantly decreased at the 18 and 24th postinsertion cycles. For the V group, the mean value decreased significantly at the 6, 12, and 18th postinsertion cycles and was below the normal level (16 ng/ml). For the T group, the mean value decreased significantly at the 12th and 18th postinsertion cycles, but the difference was not significant at the 24th postinsertion cycle as compared with preinsertion in either the V or T groups. After insertion, the mean hemoglobin (Hb) concentrations were still above 12 gm/dl in each cycle, but the incidence of Hb less than 12 gm/dl, which was zero before insertion in all groups, for the Ring group was 12.5% and 6.2% at the 12 and 24th postinsertion cycles and for the V group, 10% at the 1st postinsertion cycle, then gradually increased to 21.1% at the 24th postinsertion cycle. Menstrual flow was significantly prolonged only in the T group. This study indicated that blood loss, incidence of menorrhagia, and iron deficiency anemia were lower among Steel Ring users than among VCu 200 and TCu 220c users.
Contraception 1986 Dec
PMID:Menstrual blood loss, haemoglobin and ferritin concentration of Beijing women wearing steel ring, VCu 200, and TCu 220c IUDs. 382 74

We have developed a polyacrylamide gradient gel electrophoretic method to quantitate apo-, mono-, and diferric transferrin based upon differences in their molecular size. Purified transferrin saturated to different extents (3% to 98%) with iron showed proportions of the three forms as predicted from an approximately random distribution of iron between the two metal-binding sites. The iron distributions in sera of 14 normal individuals similarly correlated with the predicted values. In contrast, 22 of 43 patients with diseases associated with abnormalities in iron or transferrin metabolism had a disproportionate increase in monoferric transferrin. This abnormality occurred in seven of nine patients who had received bone marrow transplants, seven of 14 with chronic liver disease, and eight of nine menstruating women with probable iron deficiency anemia. Interestingly, 11 patients with malabsorption or chronic renal disease had normal iron distributions. The finding of abnormal distributions of iron on transferrin suggests that gradient gel analysis may be a useful tool for studying the physiologic mechanisms controlling iron utilization.
Blood 1985 Dec
PMID:Quantitation of apo-, mono-, and diferric transferrin by polyacrylamide gradient gel electrophoresis in patients with disorders of iron metabolism. 406 29

The fluorescent porphyrin in the erythrocytes of patients with lead intoxication or with iron deficiency anemia is zinc protoporphyrin that is bound to globin moieties, probably at heme binding sites.
Science 1974 Dec 06
PMID:Zinc protoporphyrin in the erythrocytes of patients with lead intoxication and iron deficiency anemia. 446 90


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