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Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Porotic hyperostosis was observed in 34 percent of 539 crania excavated from sites in Arizona and New Mexico. Common causes of this cranial pathology in the Old World (thalassemia, sickel cell anemia, and malargia) do not explain its occurrence in the American Southwest, as malaria and hemoglobinopathies are not known to have existed in the New World prior to European contact. Iron deficiency anemia which may also be assoicated with porotic hyperostosis occurs on a mass level only with hookworm infestation or nutritionally-related iron deficiency. Since hookworm infestation is rare in the American southwest and has not been reported in prehistoric southwestern American Indians, the hypothesis of nutritional anemia was examined. In canyon bottom sites where the diet was heavily dependent on maize, which is low in iron and also contains an inhibitor of iron absorption, significantly more crania had porotic hyperostosis than in sage plain sites, where the diet included ample animal protein rich in easily absorbable iron (p less than .001). Furthermore, canyon bottom children, who were more susceptible to iron deficiency anemia, had a higher incidence of porotic hyperostosis lesions than adults (p less than .0001).
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PMID:The paleoepidemiology of porotic hyperostosis in the American Southwest: Radiological and ecological considerations. 110 84

A cobalt excretion test was performed in 50 patients with various, mainly hematologic, disorders and was found to be an accurate and easily obtainable index of iron absorption. The test was found to be of very limited value in predicting iron stores. The cobalt excretion test may have some usefulness as a simple, apparently safe, noninvasive test for identification of persons with iron depletion resulting from uncomplicated blood loss. However, in more complex circumstances, it fails to differentiate iron deficiency anemia from anemia due to other causes.
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PMID:Cobalt excretion test as index of iron absorption and diagnostic test for iron deficiency. 111 13

Free erythrocyte protoporphyrin levels were measured in 29 individuals with alpha thalassemia trait, 19 with proved iron deficiency anemia, and 25 normal control subjects. Individuals with alpha thalassemia trait and normal iron studies had FEP levels in the normal range despite marked degrees of microcytosis. In contrast, individuals with iron deficiency anemia had marked elevation of FEP levels with similar degrees of microcytosis. Measurement of FEP levels appears to be a useful tool in differentiating alpha thalassemia trait from iron deficiency anemia.
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PMID:The micromeasurement of free erythrocyte protoporphyrin as a means of differentiating alpha thalassemia trait from iron deficiency anemia. 112 99

Humoral and cellular defense mechanisms were evaluated in 20 children with iron deficiency anemia and in seven with latent iron deficiency. Serum immunoglobulin concentrations, salivary IgA, and total hemolytic complement were within normal range; C'3 concentration was increased. Tests of lymphocyte function showed impaired delayed hypersensitivity skin responses in vivo and decreased in vitro H-3-thymidine incorporation following stimulation with phytohemagglutinin and candida antigen. Tests of neutrophil function showed normal nitroblue tetrazolium dye reduction, decreased bactericidal function, and increased chemotactic activity. These abnormalities could be detected in latent iron deficiency before the development of clinical anemia suggesting that altered immunologic function was an early manifestation of iron deficiency. Normal results were obtained two to three months after iron therapy was begun. The clinical implication of these findings is disucssed in relationship to the reported susceptibility of iron-deficient children to intercurrent infections.
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PMID:The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral components. 112 23

Because of uncertainty as to the molecular weight of transferrin, a previous comparison [Von der Heul et al., Clin. Chim. Acta 38, 347 (1972)] between transferrin content of serum and total iron-binding capacity cannot be definitive. We found a conversion factor for expressing the maximum amount of iron bound by 1 mg of transferrin. We compared the resulting calculated value with values obtained by three other methods for measuring total iron-binding capacity. We agree with the previous observation that the latter, as measured radioisotopically, give higher results than would be judged from the transferrin content but the same as those for two chemical methods. The diffusion rate of transferrin in agar was the same irrespective of the degree of iron saturation. Serum transferrin concentrations were low in patients with anemia resulting from malignancy, chronic disorders, and cirrhosis of the liver, and high or normal in patients with iron deficiency anemia and in pregnant women or women who were taking birth-control pills. Measurement of transferrin concentration can be used to distinguish iron deficiency anemia from anemia resulting from chronic disorders, but offers no advantages over existing methods for estimating total iron-binding capacity.
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PMID:Immunological measurement of transferrin compared with chemical measurement of total iron-binding capacity. 113 10

Trying to find out the clinical elements that define the precise indication ofr a jejunal biopsy, 28 children with several pathological conditions were studied. They were 12 cases of kwashiorkor, 11 cases with chronic diarrhea, two cases of chronic pancreatitis, 2 cases with ferropenic anemia resistant to the oral treatment with iron and one case of chilous ascitis. It is concluded that only in those cases in which the biopsy is the precise medium for diagnosis is where it would be indicated, such as intestinal lymphangiectasis or in those cases with signs or evidence of malabsorption without diarrhea. The chronic diarrhea per se does not seem to be a formal indication for biopsy.
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PMID:[Diagnostic value of jejunal biopsy]. 113 14

Iron deficiency anaemia is common following vagotomy and gastro-enterostomy, and this study has shown that all the anaemic patients had low gastric secretion. After correction of their anaemia, gastric secretion was increased, but was still very low, and when these levels were compared with secretion in fit non-anaemic patients it was found that the latter group had a significantly higher secretion, and that a high proportion of them showed evidence of incomplete vagotomy. These results suggest that there is a relationship between the levels of gastric secretion in patients after vagotomy and gastro-enterostomy and the development pf anaemia. It may be that inadequate gastric secretion impairs the release of elemental iron from the diet and its subsequent absorption.
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PMID:The relationship of anaemia to gastric secretion more than 15 years after vagotomy and gastro-enterostomy. 113 30

In 23 healthy subjects and in 115 patients with various degrees of chronic iron deficiency anaemia without congenital abnormalities of globin synthesis, Hb ranged from 3.4 to 16.3 g/100 ml. HbA2 ranged from 0.0550 to 0.5250 g/100 ml. Hb and HbA2 were statistically correlated, as shown by linear regression analysis (a equals --0.1387; b equals 0.0372; r equals 0.8198; P smaller than 0.001). The second degree parabola was not statistically different, but it gave a biologically preferable Figure for intercept (a equals --0.0006; b equals 0.0070; c equals 0.0015; r equals 0.8324; P smaller than 0.001). The second degree parabola was to be preferred also on the basis of previous literature results. Shortness of iron seems to reduce more the HbA2 than the Hb levels.
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PMID:Relationship between Hb and HbA2 concentrations in healthy and iron deficient subjects. 116 84

Previously published studies have documented a reduction in the rate at which iron stores laid down by iron dextran therapy can be utilized for haemoglobin synthesis after the acute demands of haemorrhage and phlebotomy. In order to determine if a defect in the mobilization of these stores exists in the face of a chronic stimulus to red cell production, 93 patients who had previously received a total dose infusion of iron dextran were examined for a recurrence of iron deficiency anaemia, and in those in whom anaemia had recurred, iron stores were assessed by marrow aspiration. Twenty of the 93 patients were found to have recurrent iron deficiency anaemia, and marrow aspiration in all failed to demonstrate stainable iron stores. Although the rate at which iron dextran can be mobilized from storage sites is reduced, the present study demonstrates that ultimately these stores are fully utilizable.
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PMID:Utilization of iron dextran in recurrent iron deficiency anaemia. 120 Dec 25

In 17 respectively 15 children with iron deficiency anemia the effect of a combined orally applicated iron-vitamin B6 therapy and iron therapy only was studied. Pyridoxal phosphate, activities of pyridoxal kinase and red cell GOT, and excretion of 4-pyridoxic acid in urine were measured as indices of vitamin B6 nutriture before therapy was started, on the 3rd and 6th day with therapy and on the 1st and 4th day after therapy was stopped. Red cells, concentration of hemoglobin, reticulocytes and hematokrit were simultaneously counted, whereas serum iron had been measured once only before therapy. A group of 22 hematologically healthy children was studied as controls. After iron therapy a decrease of vitamin B6 nutriture occured as a consequence of an increased requirement for pyridoxal phosphate for heme synthesis. Additional vitamin B6 was followed by a normal vitamin B6 nutriture and a significantly accelerating effect on heme synthesis.
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PMID:[Activity studies of an iron-vitamin B6 preparation for euteral treatment of iron deficiency anemia]. 121 68


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