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Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bushman women appear to have sufficient stores of iron and zinc during pregnancy and lactation; as a result, iron deficiency anemia is rare in Bushman women, even in pregnancy. Hair samples from Bushman women (young nonpregnant, lactating, and postmenopausal) and men were analyzed for iron, zinc, and copper content. Values obtained were compared with those for groups of Bantu and American inner-city mothers. Mean iron levels in the hair were found to be high (173 ppm) for lactating Bushman women, as compared with 43.2 ppm in the group of Bantu women, and 22.9 ppm in the group of American inner-city women. Zinc levels also were higher in the Bushman women. Mean copper values were much higher in the American inner-city mothers (19.9 ppm) than in the Bushman women (8.0 ppm) or in the lactating Bantu women (9.9 ppm). The sum of the metals may be more important than the individual concentrations.
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PMID:Trace metal studies in Bushman hair. 97 39

The ferritin content of monocytes, lymphocytes and polymorphs is reduced in patients with iron deficiency anaemia. In patients with the anaemia of chronic disease a reduced serum iron concentration is associated with an increase in the ferritin content of all peripheral blood leucocytes. Iron uptake by all cell types is related to transferrin saturation. In iron deficiency anaemia lymphocyte iron uptake is greatly increased, possibly relfecting intracellular iron depletion. In patients with active rheumatoid arthritis and carcinomatosis there is no alteration in leucocyte iron uptake or ferritin synthesis.
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PMID:Iron uptake and ferritin synthesis by peripheral blood leucocytes from normal subjects and patients with iron deficiency and the anaemia of chronic disease. 97 35

In 90 postmenopausal women aged 55 or older residing in health care facilities, a survey was made of hemoglobin levels and food habits that reflected their consumption of iron-rich foods. The reasons for inadequate dietary intakes of iron are discussed. There is need for better understanding of iron metabolism. Recommendations are made for the prevention of iron deficiency anemia in postmenopausal women and for achievement of the highest possible level of health as affected by the intake of iron and related nutritional factors.
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PMID:Iron deficiency anemia in postmenopausal women. 99 48

Tardyferon was administered to 51 patients with iron deficiency anaemia. The drug was very well tolerated and even after administration to fasting patients it was tolerated well by 92% of patients. The iron absorption curve was on the average twice as high after 1 hour and increased up to 3 hours. A significant therapeutic effect with raised haemoglobin level by 10--27% was obtained after 4--6 weeks of treatment in 44 patients (86%). In the remaining cases the improvement was less pronounced.
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PMID:[Tardyferon-depot in the treatment of iron deficiency anemia]. 99 42

On a total of 105 persons with normal iron stores, iron depletion, and iron deficiency the intestinal absorption from therapeutic iron doses (100 mg Fe and 50 mg Fe as ferrous glycocoll sulphate) of a special galenic form was measured. The measurements were performed by means of a whole-body counter and preparations labelled with radio-iron (59Fe). Mean values of absorption rates from 100 mg Fe in healthy males were 5.0% and in healthy females 5.6% whereas in latent iron deficiency and in iron deficiency anemia mean values of 10% and 13% were obtained, respectively. The maximum absorption rate of 20 to 25% is reached already in the late stage of latent iron deficiency. Advancing severeness of iron deficiency is not followed by an increase of iron absorption. Investigations on 21 persons showed no significant difference between absorption rates of the galenic preparations used when administered orally before or after breakfast, respectively.
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PMID:[Intestinal absorption from therapeutic iron doses (author's transl)]. 103 55

The nutritional status of 66 part Aborginines was re-examined in 1974--with particular reference to blood levels of haemoglobin and vitamins--after white bread fortified with iron and the vitamins B1 and PP (niacin) had been available for six and half months to the population of Bourke, New South Wales. The results found in 1971 and 1974 are compared. A significant improvement from deficient to acceptable blood levels of vitamins B1 and B6 was found in 44% and 52% of the subjects respectively. This attributed to the comsumption of fortified bread since the levels of the other vitamins had remained either unchanged or worsened. The biochemical improvement in vitamin B6 is attributed to the sparing effect of vitamin PP on vitamin B6 requirement because the conversion of tryptophan to niacin is impaired in vitamin B6 deficiency. Iron deficiency anaemia in children had decreased by 50% but this could have been due to many other factors besides the iron which had been added to the bread. Clinically there was a marked decrease in angular stomatitis and skin xerosis which could be related to the biochemical improvement of the two B-vitamins and a decrease in active trachoma and suppurative otitis media probably due to intensive treatment received since 1971. The results of this study and the extent of biochemical vitamin B1 and B6 deficiency found in other groups, indicate that fortification of bread may be of benefit to the community as a whole.
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PMID:Nutrition in the Australian aborginines--effects of the fortification of white flour. 105 22

The correlation between the magnitude of the increase of serum iron after an oral dose of iron and the total absorption of iron was studied in 51 healthy subjects and 10 patients with iron deficiency anaemia. 59Fe-labelled solutions of ferrous sulphate (25-100 mg iron) were administered to the fasting subjects. The serum iron concentration was followed for 4-6 hours and the absorption was measured in a whole-body counter. Good correlation was found between the maximal increase of serum iron and the total amount of iron absorbed after a dose of iron given as a solution. The serum iron method may be used for comparisons of the absorbability of different doses of iron by performing cross-over studies in groups of subjects. However, it was found that in an individual subject the serum iron method could not be used to determine the amount of iron absorbed from an oral dose of iron.
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PMID:Serum iron increase as a measure of iron absorption - studies on the correlation with total absorption. 106 1

The absorption of iron from slow-release and rapidly-disintegrating ferrous sulphate tablets has been compared using a double radioiron isotope technique. The studies were performed in 15 normal subjects, 20 blood donors and 10 patients with iron deficiency anaemia. The preparations containing 100 mg of ferrous iron were given twice daily on alternate days for 10 days. The absorption differed significantly between the three groups of subjects, being highest in the anaemic patients and lowest in the normal subjects. In all groups, significantly more iron was absorbed from the slow-release tablets compared to the rapidly-disintegrating tablets. The mean absorption ratios were 1.3 in both normal subjects and blood donors. In patients with iron deficiency anaemia the ratio was 1.4.
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PMID:Absorption of iron from slow-release and rapidly-disintegrating tablets - a comparative study in normal subjects, blood donors and subjects with iron deficiency anaemia. 106 5

Diagnosis is often overlooked because symptoms develop slowly and insidiously and many patients don't complain about them. Then too, the giddiness, apathy, confusion, clumsiness, and similar problems may be considered simply signs of "old age." Iron deficiency anemia is the most common type in old people. It's usually due to gastrointestinal bleeding, but there may be a second, less obvious cause. The classic picture of low serum iron, high total iron-binding capacity, and low iron-binding saturation is sometimes distorted. Usually, many studies are needed to confirm the suspicion of a vitamin B12 or folic acid deficiency. A raised mean corpuscular volume in itself signals the need for further investigation. In patients with macrocytosis, the bone marrow must be examined. Tests for intestinal malabsorption must be considered too. Repeated blood tests are essential in patients being treated for any type of anemia. Iron deficiency may hide evidence of folate or B12 deficiency. And iron therapy may lessen bleeding from colonic cancer, delaying diagnosis until it's too late to operate.
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PMID:Anemia--a common but never a normal concomitant of aging. 108 61

The last 30 years have shown marked improvements in formula feeding of infants. A decrease in breast-feeding popularity and improved sanitary formula methods are responsible for increased use of formulas. Because an infant's growth rate is highest from birth to 1 year, nutritional adequacy of the diet is of vital importance. Necessary for evaluating an infant's formula are the following: 1) the formula should have essential nutrients but not in excess; 2) it should be readily digestible; and 3) there should be a reasonable distribution of calories derived from protein, fat and carbohydrates; digestibility of the fat source is important. Iron deficiency anemia, the most prevalent deficiency in infants, is remedied by the use of iron-fortified commercial formulas. The most effective nutritionally balanced milk is human milk. 2 reasons for other choices are infantile abnormal conditions which require therapeutic formulas or the mother's choice not to breast-feed. A comparison of cow's and human milk shows that the former has 3 times as much ash and protein (which alters digestibility) than normally found in the latter. Differences in casein or curd content triglycerides and percentage of carbohydrates are sufficient to render human milk more easily digestible and nutritionally complete than cow's milk. Standard formulas, on the other hand, nutritionally approximate cow's and human's milk by chemically altering casein proteins, replacing butterfat with vegetable oils and creating highly concentrated electrolyte replacements for electrolyte loss during diarrhea and vomiting. A wide variety of therapeutic formulas are employed for milk allergy, fat restrictions, congenital heart disease, low birth weight infants and phenylektonuria. Preparation of infant formulas include ready-to-feed, concentrated liquid and concentrated powder. Proper dilution in the latter 2 is stressed as is the absolute need for sterilization of all equipment used in formula preparation. The appropriate choice would be a formula that is well tolerated by the infant, conveniently stored and prepared, and within the family budget.
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PMID:Infant formulas. 109 87


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