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Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study examined the effect of long-term administration of reserpine, an adrenergic blocking agent, on cardiac hypertrophy in animals with severe iron deficiency anaemia. This condition was induced by feeding rats on an iron-deficient diet for 30 days from the time of weaning. Anaemia was indicated by lowering of blood haemoglobin levels. Reserpine was administered i.p. (0.15 mg/kg body wt) every day during the experiment. Marked cardiac hypertrophy, as indicated by increase heart weight and increased size of cardiac muscle cells, was evidenced in iron-deficient rats, while the heart weights and myocardial cell size of drug-treated anaemic rats were in the normal range. The successful prevention of cardiac hypertrophy in anaemic iron-deficient rats by reserpine administration supports the hypothesis that noradrenaline plays a key role in the cardiac-hypertrophy process in iron deficiency anaemia.
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PMID:Pathogenesis of cardiac hypertrophy in iron deficiency anaemia: the role of noradrenaline. 621 77

The effect of iron deficiency anemia on the catecholamine levels and morphology of the heart was studied in young male Wistar rats. The iron-deficient rats showed mild restriction of body weight gain and a striking lowering of blood hemoglobin concentration. In addition the present study demonstrated that the experimental iron deficiency anemia induces cardiac hypertrophy, as revealed by increased heart weight associated with increased size of cardiac muscle cells, as well as decreased myocardium catecholamine levels. The possible meaning of the neurohormonal change in the pathogenesis of the hypertrophic heart is discussed.
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PMID:[Morphological and biochemical changes of the heart in experimental hypochromic anemia in rats]. 622 8

Noradrenaline levels and heart morphology were studied in animals with severe iron deficiency anaemia. This condition was induced by feeding rats an iron-deficient diet for 30 days from the time of weaning. Anaemia was indicated by the lowering of blood haemoglobin levels. Statistically significant decreases in myocardial noradrenaline levels associated with cardiac hypertrophy, as revealed by increased wet heart weight and increased size of cardiac muscle cells, were observed in anaemic rats compared with controls.
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PMID:The effect of iron deficiency anemia in the rat on catecholamine levels and heart morphology. 645 88

Clinical-and-hemodynamic manifestations of heart failure were studied in 28 patients with iron deficiency anemia (IDA). Half of the IDA patients have been found out to develop the heart failure syndrome of both systolic and diastolic variant. Decrement in exercise tolerance in the above patients is due to anemia as well as to development and progression of the cardiac muscle dysfunction, which fact warrants an in-depth diagnostic quest together with an optimum treatment.
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PMID:[Clinical and hemodynamic characteristics of heart dysfunction in patients with iron deficiency anemia]. 1207 49