Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
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Target Concepts:
Gene/Protein
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Query: UMLS:C0162316 (
iron deficiency anemia
)
3,806
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A new, specific, and simple method for the determination of
delta-aminolevulinic acid
(ALA) synthetase activity in human bone marrow cells has been developed. ALA synthetase of erythroblasts was partially purified so as to permit the use of [(14)C]succinyl-CoA as a substrate for this enzyme. In this enzyme preparation there were negligible activities of succinyl-CoA hydrolase, alpha-ketoglutarate dehydrogenase, and succinyl-CoA synthetase and there was no activity of ALA dehydrase. The ALA formed from [(14)C]succinyl-CoA has been isolated by column chromatography. Radioactivity in the eluate from the column has been proved by paper chromatography to be exclusively that of [(14)C]ALA. The entire assay can be completed within 4 h, and [(14)C]succinyl-CoA was incorporated into [(14)C]ALA on the order of several percent. Moderate to marked decreases of ALA synthetase activity have been demonstrated in the erythroblasts of all cases of sideroblastic anemia. In the cases of
iron deficiency anemia
, on the other hand, normal or slightly elevated activity has been obtained.
...
PMID:Measurement of delta-aminolevulinic acid synthetase activity in human erythroblasts. 482 27
Some enzymes and intermediates of heme synthesis were determined in blood and urine of 26 women with severe
iron deficiency anemia
(
IDA
). Erythrocyte free protoporphyrin was almost doubled and
delta-aminolevulinate
dehydrase significantly raised. But urinary excretion of
delta-aminolevulinic acid
and reticulocyte ferrochelatase were significantly reduced in
iron deficiency anemia
. Hence these could serve as useful indices of iron deficiency and consequent anemia.
...
PMID:Some biochemical changes in heme synthesis in iron deficiency. 1121 7
