Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reference values for Ferritin Flex on the Dimension RxL analyzer calibrated against the 3rd International Standard for Ferritin (recombinant) and N-Latex Ferritin on the BNA II nephelometer calibrated against the 2nd International Standard for Ferritin (spleen) both from Dade Behring (Marburg, Germany) were established (77 men and 182 women). Exclusion criteria were iron deficiency or iron deficiency anemia, inflammation, liver disease, malignancy, and other hematological or chronic disorders. The reference values (5.0th-95th percentiles) were as follow: for N-Latex Ferritin - men, 12-399 microg/l; women <50 years, 11-102 microg/l and women > or =50 years, 17-219 microg/l; for Ferritin Flex - men, 14-415 microg/l; women <50 years, 11-111 microg/l and women > or =50 years, 22-224 microg/l. Both assays correlated very closely with each other (r=0.993). The linearity was acceptable down to 2 microg/l for the Ferritin Flex method, but only down to 15 microg/l for the N-Latex Ferritin assay. The mean recovery of the 3rd International Standard by N-Latex Ferritin and Ferritin Flex was comparable (approximately 80%). We conclude that the new Ferritin Flex assay, which is based on the new 3rd International Standard, should be used for ferritin measurement in the routine medical laboratories in the future.
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PMID:Reference values for a heterogeneous ferritin assay and traceability to the 3rd International Recombinant Standard for Ferritin (NIBSC code 94/572). 1205 77

It has been established through several decades of research that children's home environments significantly influence their development. Many researchers have also been interested in expanding research beyond indirect measures of the home environment, such as socioeconomic status, to help understand the nature of specific environmental mechanisms which influence early behavior and cognitive development. The Home Observation for Measurement of the Environment (HOME) Inventory was developed to meet these needs. Specifically, HOME measures the quality of stimulation in a child's early family environment. Almost all studies of the approach's reliability and validity have been conducted with US samples. HOME is, however, being used in other countries. The authors report their findings from a study of whether the psychometric properties of HOME based upon US samples parallel those found in Costa Rica, and whether HOME discriminates between Costa Rican environments with different associations to child health and development. Focus centers upon the infant/toddler version of the HOME Inventory. HOME data for 183 healthy Costa Rican infants were compared to the original HOME standardization sample from Little Rock, Arkansas. The study found the HOME Inventory to be helpful in identifying children at risk for delayed development in this Latin American sample. Lower HOME scores related to a shorter duration of breastfeeding and differentiated children with iron deficiency anemia in infancy, a condition associated with long-lasting developmental disadvantage.
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PMID:Using the HOME inventory with infants in Costa Rica. 1229 Jul 49