Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To address the hypothesis that increased infectious morbidity is associated with iron supplementation, 783 randomly selected infants were provided with a powdered full fat cow's milk (non-fortified group) and 872 with a powdered acidified full fat cow's milk fortified with 15 mg of iron as ferrous sulfate (fortified group). All infants were followed from birth to 15 months of age with a monthly home visit by a nurse who recorded morbidity occurring during the previous 30 days. At 9 months of age, 15% of infants in each cohort were receiving breast milk only; data for these infants were segregated to make the third group. Episodes (mean +/- SD) of diarrhea/infant/year were 1.06 +/- 1.29, 1.14 +/- 1.37, and 0.82 +/- 1.04 for the fortified, non-fortified and breast-fed groups, respectively; the fortified and non-fortified bottle-fed groups had a very similar incidence of respiratory illness; 2.66 +/- 2.07 and 2.74 +/- 2.24 episodes/infant/year, respectively. The incidence of respiratory illness for both bottle-fed groups was significantly higher than that for the breast-fed group (2.22 +/- 1.84 respiratory episodes/infant/year). We conclude that for the infants the tested form of iron fortified milk, which is sufficient to lower iron deficiency anemia, does not result in an increased incidence of diarrhea or respiratory illness.
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PMID:Effect of supplementation with an iron-fortified milk on incidence of diarrhea and respiratory infection in urban-resident infants. 865 75

A history of poor growth in early childhood associated with persistent diarrhea and iron deficiency anemia led to a diagnosis of celiac disease in a 9-yr-old boy hospitalized for acute rhabdomyolysis. Elevated serum creatine kinase levels had been documented over the previous years, and Becker's muscular dystrophy was diagnosed by immunostaining of dystrophin and DNA analysis.
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PMID:An unusual association: celiac disease and Becker muscular dystrophy. 867 19

Non-steroidal anti-inflammatory drugs (NSAIDs) may adversely affect the colon, either by causing a non-specific colitis or by exacerbating a preexisting colonic disease. Patients with NSAID-induced colitis present with bloody diarrhoea, weight loss, iron deficiency anaemia and sometimes abdominal pain. Colonoscopy may be normal or may show inflammation, ulceration or diaphragm-like stricture. Histology often concludes to non-specific colitis. NSAIDs may cause perforation or bleeding of colonic diverticula, may cause relapse to inflammatory bowel disease and may exacerbate bleeding of colonic angiodysplasia. Pathogenesis of NSAID-induced colitis is still controversial. Local and/or systemic effects of NSAIDs on mucosal cells might lead to an increased intestinal permeability, which is a prerequisite for colitis. Treatment of NSAID-induced colitis should be to discontinue the drug, or at least, to reduce the dose as much as possible. Sulphasalazine and Metronidazole have been successfully used in few studies. Surgery is often indicated in case of life threatening complications or untractable symptoms.
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PMID:Non-steroidal anti-inflammatory drug-induced colitis. 873 36

Coeliac disease (CD) is heterogeneous in its clinical presentation and pathological expression. Silent, latent and potential forms represent the submerged part of the so-called "coeliac iceberg". The association of insulin-dependent diabetes mellitus (IDDM) and CD has been widely reported. For the screening of CD in diabetic patients, anti-reticulin R1 (ARA-R1) and anti-endomysium (AEA) antibodies are more reliable markers than anti-gliadin (AGA) antibodies. Recent studies have reported an increased prevalence of CD in children with IDDM. In our experience intestinal biopsy confirmed a diagnosis of CD in 6 out of 172 diabetic patients, with a prevalence of 3.5%. Only occasionally does CD precede the onset of IDDM; more often CD is diagnosed shortly or sometimes years after the onset of diabetes. Typical gastrointestinal complaints of CD (such as diarrhoea, abdominal distension) are rare in IDDM patients, while atypical isolated signs or symptoms of CD are more common, in particular sideropenic anemia, short stature, delayed puberty, epilepsy, hypertransaminasemia, dyspeptic symptoms, herpetiform dermatitis, and recurrent aphthous stomatitis. It is recommended that all diabetic children, even those asymptomatic, should be screened yearly for CD, using a combination of AGA plus ARA-R1 and AEA.
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PMID:Clinical aspects of coeliac disease in children with insulin-dependent diabetes mellitus. 888 60

A 7-month-old infant presented at a tertiary centre with a 6-day history of a skin rash, fever and diarrhoea. Clinical features included pyrexia, kwashiorkor, extensive ulcerating skin lesions suggestive of ecthyma gangrenosum, hepatomegaly, meningismus, neutropenia and iron deficiency anaemia. Blood and skin aspirate cultures yielded a positive growth of Pseudomonas aeruginosa. Apart from severe protein energy malnutrition, no other causes of immunodeficiency were found. He responded well to parenteral antibiotic therapy with gentamicin and piperacillin.
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PMID:Community-acquired Pseudomonas aeruginosa infection in an infant. 889 49

A 70-year-old woman was admitted to the hospital because of a 5-year history of weight loss, weakness, anemia, osteomalacia, pathologic fractures and pain responding only to narcotic analgesics. A diagnosis of celiac disease was made on the basis of pathologic xylose absorption test results, studies confirming the presence of antigliadin and antiendomysial antibodies, and jejunal biopsy evidencing shortened or absent villi. The detection of unusual cases of celiac disease without diarrhea is on the increase. The only observable symptoms of this pathology may be osteomalacia or persistent iron deficiency anemia despite oral iron therapy.
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PMID:[Diagnosis of celiac disease in an elderly subject: description of a clinical case]. 907 71

Recent studies have been reported for coeliac disease a new prevalence: 1:200 in Europe, 1:184 in Italy. These improvements have been possible for new diagnostic methods and techniques available today: antigliadin, antireticulin and antiendomysium antibodies. These serologic markers have been detected, in recent advances, new clinical presentations for coeliac disease: not only typical gastrointestinal symptoms (diarrhea, recurrent abdominal pain, etc), but many atypical symptoms have been described: sideropenic anemia, short stature, growth retardation, dermatitis herpetiformis, small alterations, alopecia, etc. New groups of patients have been also identified: some patients, clinically asymptomatic, with positive serology and a small intestinal biopsy suggestive for coeliac disease; they have shown histopathologic improvement with gluten free diet ("silent" coeliac disease). Another interesting group consists of asymptomatic patients with a positive serology for AGA and AEA antibodies, but normal gastrointestinal biopsy with free diet; they develop later in life, mucosal atrophy and normalization after gluten free diet ("latent" coeliac disease). It must be emphasized that classes of antibodies (in association with peroneal biopsy) have been identified in the last years, new clinical presentations of coeliac disease and new associations with other autoimmune pathologies.
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PMID:[Celiac disease today]. 926 2

Celiac disease is much common than previously thought with a prevalence of 1/300, but most of cases are poorly symptomatic or silent. Fewer of half of patients report diarrhoea as a presenting symptom. In adults, the diagnosis should be considered, in case of isolated iron deficiency anaemia, neurological symptoms (ataxia, epilepsy), osteoporosis and arthralgia, infertility, dermatitis herpetiformis and abnormalities in liver tests. Characteristic histological features are total or subtotal villous atrophy associated with an increased number of intraepithelial lymphocytes. The most sensitive and specific circulating antibodies for the diagnosis are endomysial and transglutaminase IgA antibodies. The treatment of celiac disease requires a strict gluten free diet, but the observance to this diet is often difficult. In patients refractory to a strict gluten free diet, serious complications such as intestinal lymphoma or refractory sprue should be considered.
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PMID:[Adult celiac disease]. 1145 9

Increased awareness of non-classical presentations and more reliable screening tests have led to higher detection rates for coeliac disease in elderly adults. Clinical presentations are influenced largely by the long-standing course of the subclinical disease before diagnosis. In the majority of elderly patients, weight loss, diarrhoea and iron deficiency anaemia are present. With a delay in diagnosis, there are increased risks of associated autoimmune diseases, of neoplasms (mostly small bowel lymphoma) and of metabolic bone diseases. Thyroid disease is the most common autoimmune disease. Lymphoma may be the initial presentation or may complicate the clinical course of well established coeliac disease. Osteopenia is very common at presentation, can be clinically severe and require specific therapy in addition to the gluten-free diet. The high risk of complications in elderly patients with coeliac disease warrants a systematic approach in their investigation and management.
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PMID:Coeliac disease. 1197 27

INTRODUCTION: Fast Track Colorectal Clinics are becoming a requirement to meet the government's 10-day rule for patients with suspected cancers to be seen by a specialist. However, such clinics soon tend to get overwhelmed by huge numbers of referrals, many of them inappropriate. The Association of Coloproctology of Great Britain and Ireland has published criteria for appropriate referral. We evaluated the sensitivity of these criteria and attempted to recommend appropriate changes. METHODS: Data of 50 consecutive colorectal cancers from our DGH since January 2000 has been collected in relation to demographics, presenting signs and symptoms, haemoglobin levels as well as treatment. The new Criteria were then applied strictly to these cases and we evaluated whether these patients would have been eligible for fast track referral, if these criteria had been in force since January 2000. RESULTS: Forty-one (82%) of 50 patients would have been eligible for referral as follows: 11 (22%) rectal bleeding with diarrhoea; 8(16%) persistent diarrhoea without bleeding (>60 years), 12 (24%) bleeding without anal symptoms (>60 years), 0 (0%) palpable right sided abdominal mass, 7 (14%) palpable rectal mass, 16 (32%) iron deficiency anaemia (<11 g/dl in men & <10 g/dl in women), 10 (20%) patients qualifying on more than one criterion. However, 9 (18%) patients had presenting features that would have excluded them from a fast track referral as follows: 4 (8%) only abdominal pain + weight loss (48, 54, 72, 75 years old), 2 (4%) change in bowel habit + no rectal bleeding (54, 57 years old), 1 (2%) palpable mass at a site other than the right side of the abdomen. CONCLUSIONS: We feel that this study, although small, highlights the dangers of having very rigid criteria for such clinics. The new criteria though high in specificity have low sensitivity for safety. We recommend some modifications to the criteria as follows: rectal bleeding without anal symptoms >50 years instead of 60 years; patients with a palpable mass anywhere on the abdomen; and the adddition of a new criterion of abdominal pain with weight loss. These modifications would significantly increase the sensitivity from 82% to 94%.
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PMID:The effectiveness of new criteria for colorectal fast track clinics. 1278 Jun 33


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