Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the past three years 42 patients with heterozygous beta-thalassemia have been observed in our clinic. This group included 39 foreign and three German patients. A ratio of the MCV and the number of erythrocytes below 14 and normal serum iron level distinguish between the hereditary anemia and iron deficiency anemia. The diagnosis is confirmed by haemoglobin electrophoresis. For recognition of the most frequent type in Europe - the heterozygous beta-thalassemia - the demonstration of an elevated HbA2 level by simple microcolumn technique is sufficient. Ten out of 42 patients have been operated because of cholelithiasis. Five additional persons revealed gall bladder stones by ultrasonography. The high incidence of 36% in relatively young patients probably is due to longstanding hemolysis, which produces usually radiolucent pigment stones. Therefore attempts to dissolve gall bladder stones in patients with thalassemia do not seem to be rewarding.
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PMID:[Diagnosis of heterozygous beta-thalassemia]. 707 13

Most iron in the body is utilized as a component of hemoglobin that delivers oxygen to the entire body. Under normal conditions, the iron balance is tightly regulated. However, iron dysregulation does occasionally occur; total iron content reductions cause iron deficiency anemia and overexpression of the iron regulatory peptide hepcidin disturbs iron utilization resulting in anemia of chronic disease. Conversely, the presence of anemia may ultimately lead to iron overload; for example, thalassemia, a common hereditary anemia worldwide, often requires transfusion, but long-term transfusions cause iron accumulation that leads to organ damage and other poor outcomes. On the other hand, there is a possibility that iron overload itself can cause anemia; iron chelation therapy for the post-transfusion iron overload observed in myelodysplastic syndrome or aplastic anemia improves dependency on transfusions in some cases. These observations reflect the extremely close relationship between anemias and iron metabolism.
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PMID:[Iron dysregulation and anemias]. 2645 28