Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report a case of multiple colonic metastases of a gastric signet ring cell adenocarcinoma, presenting as colonic polyposis revealed by diarrhea, iron deficiency anemia, and left supraclavicular lymph node.
Dis Colon Rectum 1991 Jul
PMID:Metastases of a gastric adenocarcinoma presenting as colonic polyposis. Report of a case. 164 92

Juvenile polyps are a common cause of rectal bleeding in the pediatric age group. These polyps are usually solitary, but occasionally polyposis can be identified by barium-enema or colonoscopy examinations. The benign nature of a single polyp or even scattered polyposis in childhood has been supported by several authors. A case of diffuse juvenile polyposis of the colon with associated adenomatous polyps of the colon in a 17-year-old who presented with iron deficiency anemia and rectal prolapse is discussed. This combination of diffuse juvenile polyposis and adenomatous polyps is an uncommon entity which is left to represent a premalignant lesion that warrants appropriate therapy. A review of the literature concerning the cause, diagnosis, and treatment of juvenile polyps is also discussed.
Dis Colon Rectum 1981 Apr
PMID:Diffuse juvenile polyposis of the colon: a premalignant condition? 697 47

Systemic disease can produce changes in the nails. Perhaps the best known example of this is koilonychia as a sequale of iron deficiency anemia. "Half and half nail" is a type of pseudoleuconychia that can be caused by chronic renal disease, Kawasaki's disease, cirrhosis, and zinc deficiency. It has not been described in patients with Crohn's disease yet. Four male patients with Crohn's disease were observed. None of them had extraintestinal manifestations of Crohn's disease. The average duration of the disease was 5.25 (range, 1-10) years. The nail alterations were defined with a portion of the nail being as much as 15 to 40 percent of normal color distally, whereas the rest of the nail was white. The contrast between the two zones remains sharply demarcated even after constricting venous return. Histologic examination was not performed. Every patient had zinc deficiency but not hypalbuminaemia or sideropenia. After review of relevant literature (MEDLINE, PubMed, etc.), we found that half-and-half nail had not been described in Crohn's disease. This study was designed to highlight the fact that the half-and-half nail, which was thought to be a sign of chronic renal failure, also occurs in patients with Crohn's disease. The relationship of this symptom to clinical activity cannot yet be assessed and has only been observed in four cases.
Dis Colon Rectum 2006 Jul
PMID:The half-and-half nail: a new sign of Crohn's disease? Report of four cases. 1669 71