Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162316 (iron deficiency anemia)
 3,806 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Enlarged spleen, fever, increased susceptibility to infections, and thrombocytosis, are manifestations of iron deficiency which are relatively specific of pediatric patients. Iron deficiency anemia is part of everyday pediatrics. Patients are referred to the hematologist in the following situations: 1) Therapy is ineffective for one of the following reasons: the hypochromic anemia is not caused by iron deficiency (hemoglobinopathies); iron is less efficiently used because of transferrin deficiency or infectious, inflammatory or cancerous disease; iron therapy is inadequate either because of insufficient dosage or of suboptimal duration. 2) A relapse occurs in spite of adequate therapy. Before investigating the digestive tract, abnormal hemostasis. Osler-Weber-Rendu syndrome and pulmonary hemosiderosis should be considered. 3) Iron deficiency anemia is less common in adolescents. This condition, known as chlorosis, results mainly from increased needs, unbalanced diet, and onset of menses. In some cases no explanation is found but iron therapy leads to recovery. 4) Difficult problems arise in patients with complex anemias: iron deficiency with folic acid or vitamin B12 deficiency; hyposideremia complicating one of the hemoglobinopathies.
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PMID:[Iron-deficiency anemia. Hematologist's viewpoint]. 629 49

In light of the current interest in anorexia nervosa, this historical study explores the relationship of culture to age- and gender-specific symptomatologies. Between 1870 and 1920, chlorosis, a form of anemia, was widely reported in female adolescents in the United States. Diagnosis occurred on both the clinical and popular levels, yet neither the etiology nor the symptoms were precisely clear. Treatment generally included rest and large doses of iron salts. In large part, chlorosis was a cultural construction embedded in the context of Victorian medicine and family life. Physicians expected to see chlorosis in adolescent girls in the process of sexual maturation; girls learned to have the disease from family, friends, the popular press, and their doctors. Changes in diet and nutrition after 1900, coupled with increased understanding of ovarian function and iron deficiency anemia, provide only a partial explanation of the disease's eventual decline. By 1920, a changed social environment made chlorosis a social liability for girls and their mothers.
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PMID:Chlorotic girls, 1870-1920: a historical perspective on female adolescence. 675 9