Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0162275 (
ketonuria
)
553
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report a case of IDDM which occurred during interferon therapy for chronic hepatitis. A 31-year-old man intermittently received 2.5 x 10(8) units of alpha-
IFN
and 1 x 10(8) units of beta-
IFN
for treatment of chronic viral hepatitis type B. Four years after the beginning of
IFN
therapy, he acutely developed moderate hyperglycemia and severe
ketonuria
with positive islet cell antibody, and then 28 units/day of insulin injection was started. After the start of insulin therapy, there was a remission period for about 3 years but insulin-dependency recurred thereafter. The clinical course of this case indicates that
IFN
therapy precedes IDDM. During and after
IFN
therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.
...
PMID:Occurrence of IDDM during interferon therapy for chronic viral hepatitis. 801 61
