Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162275 (ketonuria)
 553 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have evaluated the clinical and immunogenetic features of 100 consecutive patients presenting to an adult diabetic clinic who were judged clinically to need insulin therapy but were not sufficiently ill to be admitted to hospital. Over this same period 15 newly diagnosed patients (aged 13-70 years) were started on insulin as in-patients of whom ten were in ketoacidosis. The 100 out-patients, aged 11-75 years at the time of starting insulin, were followed for at least a year. Fifty-six had islet cell antibodies and/or were heterozygous for HLA DR3 and DR4 (Group A) whereas 44 had neither of these markers (Group B). Islet cell antibodies and/or DR3, DR4 heterozygosity were most common in the 70 patients diagnosed below the age of 40 years but were also found in older patients. Patients in Group A were significantly younger at diagnosis (29 vs. 43 years), had a shorter duration of symptoms (17 vs. 61 weeks), were more likely to have ketonuria, and had a lower random C-peptide level at diagnosis (0.2 vs. 0.31 nmol/l). The two groups could not be distinguished by weight, haemogloblin A1 or blood glucose at diagnosis or by diabetic control or insulin dose after one year. The National Diabetes Data Group (NDDG) definition of insulin dependence stresses the importance of HLA types and islet cell antibodies although we found their prevalence to be low in the 30 patients diagnosed over 40 years who clinically were indistinguishable from the younger patients.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Insulin dependence: problems with the classification of 100 consecutive patients. 295 12

It seems rational to consider that residual insulin secretion is one of the factors which determine the short-term course of inaugural type I diabetes. But what about the mid-term course? We evaluated prospectively the insulin reserve (fasting and post-prandial C peptide) in 52 patients throughout the subsequent development of the disease. The patients (36 men, 16 women, mean age 35 years), who presented with ketonuria and weight loss, received a 10-day course of intensive insulin therapy, after which a remission of insulin dependence was observed in 40 of them (77 per cent). These 40 patients differed from those who had no such remission in that they were heavier and had a better initial insulin secretion. There was no significant difference between the two groups with regards to immunogenetic markers (presence of anti-islet antibodies 28/35 vs 8/12, DR3 and/or DR4 tissue group 27/37 vs 8/10). Following intensive insulin therapy, the C peptide value was consistently increased. At 6, 12 and 18 months the insulin secretion in patients of the remission group remained stable and always higher than that of patients who did not have a remission and whose insulin secretion collapsed at 18 months. Another characteristic of the remission group was that C peptide secretion could be stimulated by meals throughout the follow-up period (post-prandial C peptide at 18 months: 0.63 nmol/l). It is concluded that residual insulin secretion is one of the most effective predictive factors of remission when type I diabetes is first diagnosed and remains stable for the first 18 months of the disease in patients who show a remission.
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PMID:[Development of insulin reserves in the first 18 months in the insulin-dependent diabetic with or without remission of insulin-dependence]. 297 70

In a prospective study of 195 newly-diagnosed diabetic patients aged 65 years or over, 80 (41.0 per cent) were treated initially by diet, 89 (45.6 per cent) by diet and oral hypoglycaemic agents, and 26 (13.3 per cent) by diet and insulin. Fifteen patients (7.7 per cent) died within a year of diagnosis. Of 26 patients treated with insulin, six died in the first year, 14 were successfully transferred to diet and oral agent treatment and six continued on insulin--two of whom failed to a trial of oral agents, two showed only a temporary response and two received no trial. A further nine patients were taking insulin 12 months after diagnosis because of no response (eight patients) or a transient response (one patient) only to oral agents. Age, percentage ideal body weight, history of acute onset, blood glucose, glycosylated haemoglobin, and random C-peptide concentration at diagnosis did not discriminate between patients requiring insulin at 12 months and those successfully treated without insulin. Patients who were insulin-dependent 12 months after diagnosis had an increased frequency of ketonuria at diagnosis and a previous medical history of endocrine disease. In insulin-dependent patients there was an increased frequency of HLA DR3 but not DR4 and an increased frequency of thyroid microsomal and gastric parietal cell antibodies but not islet cell antibodies. It is concluded that elderly newly-diagnosed diabetic patients who are treated at diagnosis with insulin are not necessarily insulin dependent and can be given a trial of oral agents with safety.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Clinical characteristics and aetiological classification of insulin-dependent diabetes in the elderly. 330 56