Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0162275 (ketonuria)
 553 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An eight-year-old male pig-tailed macaque developed clinical signs of diabetes mellitus: constant glucosuria, uriposia, fasting hyperglycemia, hypertriglyceridemia, marked pre-beta-hyperlipoproteinemia, glucose intolerance, hypoinsulinemia and hyperglucagonemia during intravenous glucose tolerance tests (IVGTT). During a ten-month period of intensive surveillance, the monkey's body weight decreased, but ketonemia or ketonuria were never observed. Exocrine pancreatic functions remained normal.
J Med Primatol 1980
PMID:Diabetes mellitus in a pig-tailed macaque (Macaca nemestrina). 677 9

Case history The two obese mandrills (Mandrillus sphinx) showed clinical signs of depression, anorexia, hyperglycemia, hypertriglyceridemia, glucosuria, proteinuria and ketonuria. Septic bed sore wounds were noted on both fore and hind limbs. Results Histopathological study revealed severe islet amyloidosis in both mandrills. Immunohistochemical study using polyclonal anti-cat amylin antibody confirmed derivation of the islet amyloid from islet amyloid polypeptide (IAPP). Cardiomyopathy and myocardial fibrosis were also evident. Conclusions The present study documents diabetes mellitus in two obese mandrills. Diabetes in these animals had features very similar type 2 diabetes mellitus of humans, including the development of severe, IAPP-derived islet amyloidosis. The mandrill may, therefore, serve as an animal model of human type 2 diabetes mellitus.
J Med Primatol 2008 Jun
PMID:Spontaneous diabetes mellitus in captive Mandrillus sphinx monkeys: a case report. 1819 24