Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nostoc sp. strain MAC cyanobacteria were green in color when grown in white light at 30 degrees C and contained phycobilisomes that had phycoerythrin and phycocyanin in a molar ratio of 1:1. Cells grown for 4 to 5 days in green light at 30 degrees C or white light at 39 degrees C turned brown and contained phycoerythrin and phycocyanin in a molar ratio of greater than 2:1. In addition to the change in pigment composition, phycobilisomes from brown cells were missing a 34.5-kilodalton, rod-associated peptide that was present in green cells. The green light-induced changes were typical of the chromatic adaptation response in cyanobacteria, but the induction of a similar response by growth at 39 degrees C was a new observation. Phycobilisomes isolated in 0.65 M phosphate buffer (pH 7) dissociate when the ionic strength or pH is decreased. Analysis of the dissociation products from Nostoc sp. phycobilisomes suggested that the cells contained two types of rod structures: a phycocyanin-rich structure that contained the 34.5-kilodalton peptide and a larger phycoerythrin-rich complex. Brown Nostoc sp. cells that lacked the 34.5-kilodalton peptide also lacked the phycocyanin-rich rod structures in their phycobilisomes. These changes in phycobilisome structure were indistinguishable between cells cultured at 39 degrees C in white light and those cultured at 30 degrees C in green light. A potential role is discussed for rod heterogeneity in the chromatic adaptation response.
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PMID:Regulation of Nostoc sp. phycobilisome structure by light and temperature. 641 91

The study covered 10 types of anion dyes for leather: Crimson 4RT, Gray M, Solid Blue, Red 8S, Black N, Brown 46, 673, 911, 551, 557. According to LD50 criterion they all were assigned to IV jeopardy class. It instilled per os 30 times, the chemicals induced mild hemotoxic effect similar to that of methemoglobin-formers, in half of the cases affected gonads. Allergic and local irritating skin effects were unusual. Solid Blue and Crimson 4RT dyes were subjected to inhalation trials. Limcf for those two equal 51.8 and 38.0 mg/m3 respectively Limch--8.3 and 7.1 mg/m3, measured through changes in red blood parameters, behavioral response and other reactions. With consideration of Limch, toxicity for gonads and embryos, mutagenicity, the authors justified the MAC for Crimson 4RT dye in the air of workplace--1 mg/m3 (II jeopardy class), for Solid Blue dye--5 mg/m3 (III jeopardy class).
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PMID:[Toxicity dynamics of anionic dyes in the air of a work place and long-term effects after absorption through the skin]. 758 91