Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The type III iodothyronine deiodinase metabolizes the active thyroid hormones thyroxine and 3,5,3'-triiodothyronine to inactive compounds. Recently, we have characterized a Xenopus laevis cDNA (XL-15) that encodes a selenoprotein with type III deiodinase activity (St. Germain, D.L., Schwartzman, R., Croteau, W., Kanamori, A., Wang, Z., Brown, D.D., and Galton, V.A. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 7767-7771). Using the XL-15 as a probe, we screened a rat neonatal skin cDNA library. Among the clones isolated was one (rNS43-1) which contained a 2.1-kilobase pair cDNA insert that manifested significant homology to both the XL-15 and the G21 rat type I deiodinase cDNAs, including the presence of an in-frame TGA codon. Expression studies demonstrated that the rNS43-1 cDNA encodes a protein with 5-, but not 5'-, deiodinase activity that is resistant to inhibition by propylthiouracil and aurothioglucose. Northern analysis demonstrated a pattern of tissue expression in the rat consistent with that of the type III deiodinase and site directed mutagenesis confirmed that the TGA triplet codes for selenocysteine. We conclude that the rNS43-1 cDNA encodes the rat type III deiodinase and that the types I and III deiodinases present in amphibians and mammals constitute a family of conserved selenoproteins important in the metabolism of thyroid hormones.
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PMID:Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase. 762 63

Bovine collagen was functionalized by extensive process modifications for fabricating tanned bovine collagen fibers (TBCFs), as a new semisynthetic macro-, meso- and micro- porous adsorbent, of unprecedented physicochemical properties and excellent industrial waste removal efficiency. Mere or interactive effects were rationally understood, via analyzing monomer-dimer equilibrium, H-/J-aggregate formation, H-bonding, metachromasia, dye-dye complex formation etc., through extensive UV-vis analyses, during removal of acidic, like Acid Brown 369 (AB369), Acid Red 131 (AR131) and Acid Blue 113 (AB113) and basic, like Methylene Blue (MB) dyes. A new strategy was introduced to determine the allocations of these dyes, within macro-, meso- and micro-pores of TBCF, confirmed by FTIR, TGA, DTG, DSC, XRD, SEM, EDX analyses, of both loaded and unloaded TBCFs, and by measuring isotherm, kinetics, diffusion and thermodynamics parameters of adsorption. Freundlich, Langmuir and Sips models were best fitted to AR131, AB113 and AB369, respectively. Interactive effects of concentration, temperature and time, on adsorption capacities (ACs), were optimized via response surface methodology (RSM). ACs of AR131, AB113 and AB369 were 38.29, 78.14 and 73.25mgg-1, respectively, at optimum conditions (i.e. adsorbent dose=0.25g, pHi=4, concentration=200ppm and temperature=299K).
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PMID:Fabrication of semisynthetic collagenic materials for mere/synergistic adsorption: A model approach of determining dye allocation by systematic characterization and optimization. 2841 99

Kiwifruit bacterial canker is a devastating disease threatening kiwifruit production. To clarify the defense mechanism in response to Pseudomonas syringae pv. actinidiae (Psa), we observed phenotypic changes in resistant Huate (HT) and susceptible Hongyang (HY) kiwifruit varieties at 0, 12, 24, 48, 96, and 144 hour after inoculation (hai) with Psa. Brown lesions appeared in the inoculation areas 12 hai in HY shoots, and the lesion length gradually increased from 24 to 144 h. In contrast, no lesions were found in HT shoots at any time points. Furthermore, RNA-seq analysis showed significantly more differentially expressed genes between HT and HY at 12 hai than at any other time point. According to weighted gene co-expression network analysis, five modules were notably differentially expressed between HT and HY; pathway mapping using the Kyoto Encyclopedia of Gene and Genomes database was performed for the five modules. In MEgreenyellow and MEyellow modules, pathways related to"plant-pathogen interaction", "Endocytosis", "Glycine, serine and threonine metabolism", and "Carbon fixation in photosynthetic organisms" were enriched, whereas in the MEblack module, pathways related to "protein processing in endoplasmic reticulum", "plant-pathogen interaction", and "Glycolysis / Gluconeogenesis" were enriched. In particular, the Pti1 and RPS2 encoding effector receptors, and the NPR1, TGA, and PR1 genes involved in the salicylic acid signaling pathway were significantly up-regulated in HT compared with HY. This indicates that the effector-triggered immunity response was stronger and that the salicylic acid signaling pathway played a pivotal role in the Psa defense response of HT. In addition, we identified other important genes, involved in phenylpropanoid biosynthesis and Ca2+ internal flow, which were highly expressed in HT. Taken together, these results provide important information to elucidate the defense mechanisms of kiwifruit during Psa infection.
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PMID:Comparative transcriptome analysis of resistant and susceptible kiwifruits in response to Pseudomonas syringae pv. Actinidiae during early infection. 3077 51