Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0155339 (
Brown
)
12,436
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Brown
Norway and Lewis rats were challenged with a
Brown
Norway Moloney sarcoma tumor,
MST-1
, admixed with nonimmune peritoneal exudate macrophages syngeneic to the host; or admixed with nonimmune peritoneal exudate macrophages and hyperimmune anti-
MST-1
antibodies. In vivo growth of
MST-1
in BN and Lewis rats was inhibited by admixing
Brown
Norway or Lewis macrophages, respectively, with BN anti-
MST-1
antibodies. The inhibiting BN antibodies were of the IgG2 class, lacking IgG2a antibodies.
Brown
Norway anti-
MST-1
of IgG2 class without macrophages did not affect growth of
MST-1
.
Brown
Norway and Lewis anti-
MST-1
antibodies of IgG2a class enhanced tumor growth, whether admixed with macrophages or not. Anti-
MST-1
antibodies of IgM and IgG1 classes did not influence tumor growth. Peritoneal exudate macrophages removed from Lewis donors 8 to 10 days after inoculation of
MST-1
inhibited completely growth of the challenge tumor; macrophages of
Brown
Norway origin were inhibitory only when harvested from hyperimmune donors, that is, 40 or more days after inoculation of
MST-1
. Macrophages from hyperimmune donors were specifically cytotoxic to
MST-1
and did not inhibit an unrelated syngeneic BN tumor of chemical origin.
...
PMID:Effect of macrophages and antibodies on in vivo growth of Moloney sarcoma in the rat. 30 84
