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Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

For characterization of histopathological changes during pancreas graft rejection, pancreaticoduodenal transplants were performed in three groups: (1) Brown Norway into diabetic Lewis rats without immunosuppression, (2) Brown Norway into diabetic Lewis rats with cyclosporin A, and (3) Lewis into Lewis rats. Diffuse inflammatory infiltration of the acini by mononuclear cells indicated the onset of rejection (stage I). Shortly after acinar infiltration, damage to small and large interlobular excretion ducts occurred. This took the form of florid circumferential inflammation and vacuolar degeneration of epithelium similar to the bile duct damage seen in primary biliary cirrhosis, graft-versus-host disease, and liver allograft rejection (stage II). Thereafter, endothelialitis and destruction of islets were evident, consistent with a more advanced and irreversible stage of rejection (stage III). Acinar inflammation and moderate duct lesions were not prevented by immunosuppression but were delayed. Nonetheless, severe vascular changes and loss of islets were avoided. We conclude that duct lesions are a reliable criterion for pancreas allograft rejection. They are more sensitive than vascular changes and more specific than cellular infiltration of acinar tissue, which may also occur in infection.
Transpl Int 1991 Dec
PMID:Histological features of acute pancreatic allograft rejection after pancreaticoduodenal transplantation in the rat. 178 60

This study provides a cross-linguistic replication, using American Sign Language (ASL), of the Brown and Dell (1987) finding that when relaying an action involving an instrument, English speakers are more likely to explicitly mention the instrument if it is atypically, rather than typically, used to accomplish that action. Subjects were 20 hearing-impaired users of English and 20 hearing-impaired users of ASL. Each subject read and retold, in either English or ASL, 20 short stories. Analyses of the stories revealed production decision differences between ASL and English, but no differences related to hearing status. In ASL, there is more explicitness, and importance seems to play a more pivotal role in instrument specification. The results are related to differences in the typology of English and ASL and are discussed with regard to second-language learning and translation.
J Speech Hear Res 1991 Dec
PMID:Pragmatic and linguistic constraints on message formulation: a cross-linguistic study of English and ASL. 178 17

The effects of alcoholism and liver disease on memory functioning in alcoholics were studied by comparing four groups: normal healthy controls, alcoholics without liver disease, alcoholics with biopsy-confirmed cirrhosis, and nonalcoholics with postnecrotic cirrhosis. Memory capacity was evaluated employing the Benton Visual Retention Test (BVRT), the Rey-Osterreith Complex Figure Test, Digit Span, and the Brown Peterson four-word short-term memory test. A 2 x 2 ANOVA revealed significant main effects for both alcohol and cirrhosis on Digits Forward and the total score on the Brown Peterson test. Additionally, there were significant main effects for cirrhosis on the BVRT. The Brown Peterson test was analyzed using a repeated measures 2 x 2 ANOVA. Significant effects for cirrhosis were observed at all three interpolation periods. The effects for alcohol approached significance at the 30-sec (most difficult) interpolation period. Analysis of error patterns on the Brown Peterson test indicated that overall omission errors were most commonly made among all groups. Significant effects were found for alcohol on omissions and intrusion, while the cirrhosis factor yielded significant effects for phonemic, perseverative, and omission errors. This study demonstrates the importance of liver disease underlying the etiology of memory impairments in alcoholics. The results confirm our earlier findings that neuropsychologic deficits seen in alcoholics may be the result of the combination of alcohol abuse and liver disease.
Alcohol Clin Exp Res 1991 Dec
PMID:The role of cirrhosis in memory functioning of alcoholics. 178 89

To determine the position, dimensions, and structure of the right kidney in cattle by use of ultrasonography, the right kidney of 11 healthy Brown Swiss cows was examined 10 times within 2 weeks. A 3.5- and 5.0-MHz linear and convex transducer was placed on the right side of the cow in the lumbar region, in the paralumbar fossa, and in the last intercostal space. The echogenicity of various renal structures differed. The lobulation of the kidney in cattle could be visualized ultrasonographically; however, the cortex and medulla could not be differentiated. The distance between body surface and the right kidney was almost 3 times larger (5.3 +/- 1.71 cm, mean +/- SD) in the lumbar region than in the paralumbar fossa (1.8 +/- 0.52 cm). The vertical diameter of the kidney was remarkably smaller (5.1 +/- 0.47 cm) than the horizontal diameter (9.4 +/- 0.98 cm). In 7 cows, the thickness of the renal cortex and medulla was between 1.9 and 2.1 cm. The medullary pyramids could be visualized when the transducer was placed in the paralumbar fossa. Fourteen of 19 variables measured had a coefficient of variation between 8 and 14%. It was concluded that the ultrasonographic values determined in this study can be used as references for the diagnosis of morphologic changes in the right kidney of domestic dairy cattle.
Am J Vet Res 1991 Dec
PMID:Ultrasonographic examination of the right kidney in cows. 178 4

The Brown and Harris model of depression holds that certain "vulnerability factors"--namely early maternal loss, lack of a confiding relationship, greater than three children under the age of 14 at home and unemployment--can interact with "provoking agents" to increase the risk of depression. The validity of this model has been widely debated, with most of the discussion concerning the interactive nature of the model. There has been relatively little attention paid to the possibility that the "vulnerability factors" may be risk factors for depression. The purpose of this paper is to determine whether the four Brown and Harris "vulnerability factors" are associated with an elevated risk of depression, irrespective of whether they may interact with provoking agents. The analysis contained in this paper utilizes power analyses and confidence intervals. The findings suggest that the lack of a confiding relationship is strongly associated with depression, and that all four of the "vulnerability factors" may be associated with an increased risk of depression.
J Psychiatry Neurosci 1991 Dec
PMID:Are the Brown and Harris "vulnerability factors" risk factors for depression? 179 1

Injections of 6-hydroxydopamine in mouse neonates caused extensive and long lasting damage to the sympathetic nervous system and impaired brown fat development. Brown adipose tissue (BAT) thermogenic capacity of sympathectomized mice (up to 120 days old) was reduced because of marked reductions in the tissue mitochondrial protein content and the mitochondrial concentration of uncoupling protein, as assessed by [3H]GDP binding and immunoassay. Neonatal sympathectomy did not affect BAT DNA content. Sympathectomized mice also had reduced epinephrine-stimulated rates of oxygen consumption. BAT of sympathectomized mice failed to respond by increases in [3H]GDP binding to isolated mitochondria and uncoupling protein concentration when animals were offered a palatable high-fat dietary supplement that increased calorie intake of both normal and sympathectomized mice. The high-fat diet caused increases in body weight, carcass fat, and gonadal white fat pad weights in sympathectomized animals that were similar to those of control mice. These results show that inactivation of BAT metabolism did not accentuate the development of obesity caused by a dietary supplement rich in fat and suggest that stimulation of BAT metabolism was not very effective in counteracting the obesity-inducing effect of this diet.
Can J Physiol Pharmacol 1991 Dec
PMID:Effects of neonatal sympathectomy on brown fat development and susceptibility to high fat diet induced obesity in mice. 180 59

The influence of psychosocial factors on the incidence and evolution of depressive illness is well established. The joint study of different aspects of the psychosocial field involved in the risk of depressive illness substantiated interactions between these various factors, modulating the risk of depression. Several psychosocial models of depression, as Harris and Brown's model, have taken into account those interactions, discriminating vulnerability factors and precipitating factors (stressful life events, lasting difficulties): vulnerability factors, not inducing depression per se, increase the depressing effect of precipitating factors when both factors happen to be combined. However the validity of those models has to be confirmed, and mechanisms underlying interactions between psychosocial factors call for further elucidation. Other studies will also have to specify the role of psychological and biological variables in the way psychosocial factors interfere with the occurrence of depression.
Encephale 1991 Dec
PMID:[Psychosocial factors of depressive risk]. 180 58

The choice of an antidepressant according to the possible course of depression is a fundamental step in the treatment approach. Socio-demographic factors are considered in order to predict the outcome of depression receiving an adequate treatment. Only a few studies deal with this topic, probably because of the role the same factors play in the occurrence of depression. The influence of age, sex, marital status, socio-economic level and life events on compliance with treatment is considered as well as main clinical issues such as treatment resistance, risk of chronicity and of suicide. Generally speaking, socio-demographic factors do not constitute a major parameter when selecting an antidepressant. They are useful to identify patients at risk requiring special therapeutic measures. The poor prognosis of depression in males after 65 has must be emphatized, as well as the negative influence of life events occurring during the course of endogenous depression. Conversely, a decrease in the number of life events or a life event experiencing a new start in life, play an important role in the improvement of depression according to Brown. Those factors remain in the background of the pathological process and of its evolution, acting indirectly, with a poor association power. Moreover, most of those predictors have been determined a posteriori.
Encephale 1991 Dec
PMID:[Depressive disorders. Sociodemographic factors predicting therapeutic response]. 180 61

In patients undergoing aortic valve replacement, allograft valves stored at 4 degrees C in a nutrient medium have been associated with excellent immediate and long-term results. The effects of this method of prolonged storage on the antigenic, immunological and cellular characteristics of these grafts are incompletely understood. This study was designed to study these phenomena in rat aortic valves subjected to antibiotic sterilization and stored for up to 3 weeks in RPMI containing 10% fetal calf serum. Selected valves from Brown Norway rats were implanted heterotopically into the abdominal aorta of Lewis rats. Other valves were studied prior to transplantation. Antigenicity was determined by immunocytochemical staining using monoclonal mouse antibodies directed at Class I and Class II rat antigens. Immunogenicity was determined by duration of second-set skin graft survival following heterotopic aortic valve implant. Endothelial cell viability was determined by flow cytometric analysis of endothelial cells harvested from aortic valve allografts by collagenase digestion. Only fresh valves and valves stored for 1 day were positive for Class I antigens; no valves were positive for Class II antigens. Duration of skin graft survival was prolonged with greater duration of storage, but grafts remained immunogenic after 21 days of storage. Endothelial cell viability declined from 95% in the fresh valves to 64% after 21 days of storage. With prolonged duration of allograft valve storage at 4 degrees C, there is an attenuation of antigenicity, immunogenicity, and endothelial cell viability. Loss of endothelial cells may contribute to the changes in immunological responses to the valve allografts. The expression of antigens on the endothelial surface is not a reliable predictor of immunological response.
J Card Surg 1991 Dec
PMID:Immunogenicity, antigenicity, and endothelial viability of aortic valves preserved at 4 degrees C in a nutrient medium. 181 69

Since the initial observation by Brown (1914) that electrical stimulation applied to the habenular efferent bundle in the chimpanzee evoked a pattern of respiration which closely resembled the act of laughter, the habenular complex has remained a mysterious structure. The anatomy of the habenular complex is well delineated (Jones, 1985) forming a major component of the dorsal diencephalic conduction system. Data derived mainly from animal experimentation over the past decade point to the fact that the habenular complex functions as an important link between the limbic forebrain and the midbrain-extrapyramidal motor system. The elucidation of the functions of the habenular complex may thus significantly increase the current insight into the understanding of the interaction between behavioral and motor functions. Clearly, such information would be of great relevance for further understanding of neuropsychiatric disorders such as schizophrenia, Parkinson's disease, Tardive dyskinesia, and Tourette's syndrome in which behavioral and motor impairments are interfaced. This review summarizes anatomical, functional, and pharmacological aspects of the habenular complex and discusses its potential contribution to the pathophysiology of selected neuropsychiatric and movement disorders.
Int J Neurosci 1991 Dec
PMID:Relevance of the habenular complex to neuropsychiatry: a review and hypothesis. 182 82


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