Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is noted that rats with Heren carcinoma show alkalization of blood, decreased pH levels of the urine, hypokalemia, hypocalcemia, hypomagnesiemia, sodium and water retention, increased kalium level in the liver. Analogous changes are observed in rabbits with Brown-Pearce carcinoma. The organism of tumor-bearing rats responds to stress effects otherwise than the organism of normal animals.
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PMID:[Acid-base and water-electrolyte status in animals with experimental tumors]. 1 2

Absorption and fluorescence spectra in the red region of water-soluble chlorophyll proteins, Lepidium CP661, CP663 and Brassica CP673, pigment System II particles of spinach chloroplasts and chlorophyll a in diethylether solution at 25 degrees C were analyzed by the curve-fitting method (French, C.S., Brown, J.S. and Lawrence, M.C. (1972) Plant Physiol 49, 421--429). It was found that each of the chlorophyll forms of the chlorophyll proteins and the pigment System II particles had a corresponding fluorescence band with the Stokes shift ranging from 0.6 to 4.0 nm. The absorption spectrum of chlorophyll a in diethylether solution was analyzed to one major band with a peak at 660.5 nm and some minor bands, while the fluorescence spectrum was analyzed to one major band with a peak at 664.9 nm and some minor bands. A mirror image was clearly demonstrated between the resolved spectra of absorption and fluorescence. The absorption spectrum of Lepidium CP661 was composed of a chlorophyll b form with a peak at 652.8 nm and two chlorophyll a forms with peaks at 662.6 and 671.9 nm. The fluorescence spectrum was analyzed to five component bands. Three of them with peaks at 654.8, 664.6 and 674.6 nm were attributed to emissions of the three chlorophyll forms with the Stokes shift of 2.0--2.7 nm. The absorption spectrum of Brassica CP673 had a chlorophyll b form with a peak at 653.7 nm and four chlorophyll a forms with peaks at 662.7, 671.3, 676.9 and 684.2 nm. The fluorescence spectrum was resolved into seven component bands. Four of them with peaks at 666.7, 673.1, 677.5 and 686.2 nm corresponded to the four chlorophyll a forms with the Stokes shift of 0.6--4.0 nm. The absorption spectrum of the pigment System II particles had a chlorophyll b form with a peak at 652.4 nm and three chlorophyll a forms with peaks at 662.9, 672.1 and 681.6 nm. The fluorescence spectrum was analyzed to four major component bands with peaks at 674.1, 682.8, 692.0 and 706.7 nm and some minor bands. The former two bands corresponded to the chlorophyll a forms with peaks at 672.1 and 681.6 nm with the Stokes shift of 2.0 and 1.2 nm, respectively. Absorption spectra at 25 degrees C and at --196 degrees C of the water-soluble chlorophyll proteins were compared by the curve-fitting methods. The component bands at --196 degrees C were blue-shifted by 0.8--4.1 nm and narrower in half widths as compared to those at 25 degrees C.
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PMID:Analyses of absorption and fluorescence spectra of water-soluble chlorophyll proteins, pigment system II particles and chlorophyll a in diethylether solution by the curve-fitting method. 9 55

Sections of demineralized teeth which had received experimentally inserted restorations using a variety of materials have been stained according to the Brown and Brenn technique. Conventional cavity preparations had been made in intact areas and the cavities were dried gently without additional treatment prior to restoration. Different restorative materials were used and the teeth were extracted after 3-117 days' observation. No bacteria could be demonstrated at the dentin/filling interface or in the dentin if zinc oxide/eugenol, Ca(OH)2 mixed with water or corticonsteroid/antibiotic preparations were employed as base or lining materials. A few bacteria were found subjacent to two of seven unlined amalgam fillings and subjacent to three silicate restorations which had been lined with a polymeric material.
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PMID:Histologic demonstration of bacteria subjacent to dental restorations. 26 8

Scanning electron microscopy was used to study the formation of a dentine smear in ten premolars ground with a water-cooled diamond in an air turbine. In another ten teeth the pulp reaction in full crown preparation with the same armamentarium was investigated by histological techniques. The findings revealed the formation of a dentine smear which was easily removed by light polishing with wet pumice, leaving plugs of debris in the tubule apertures. The clinical significance of these findings needs further investigation. No bacteria were demonstrated on the prepared surfaces either in the scanning electron micrographs or histologically when stained with Brown & Brenn stain. Severe, acute pulp reactions were observed subjacent to the dentinal tubules cut in full crown preparation. This technique should therefore be limited to superficial use only.
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PMID:Dentine/pulp reactions to full crown preparation procedures. 33 Aug 29

Parameters have been specified for electron beams with energies 5--45 MeV from a Brown Boveri betatron for use in computerised dosimetry calculations. A semi-empirical equation is given for the dose at any point at various depths in water. This equation is a modification to Kawachi's predictive model which was based on solutions of a general age--diffusion equation. The depth doses and isodose curves are predicted as a function of the practical range, source skin distance (SSD) and field size. Depth dose accuracy requirements of +/-2% above 50% depth dose and +/-5% at lower doses, relative to maximum dose, have been set and achieved. Also, the shape of the isodose curves with the constrictions at higher doses and bulging at lower values are accurately predicted. Computer calculated beams have been used to generate summed isodose distributions for certain clinical situations.
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PMID:Betatron electron beam characterisation for dosimetry calculations. 45 Sep 71

Phospholipid head group conformations in 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE), DPPC-cholesterol, and DPPE-cholesterol dispersions, in excess water above the pure lipid gel to liquid-crystal phase transition temperature, have been calculated by using comparisons between experimental 2H and 31 P NMR spectral parameters and theoretical results obtained from a plausible model of head group motions. The new calculations are compared with results obtained in previous studies [Seelig, J., Gally, H. U., & Wohlgemuth, R. (1977) Biochem, Biophys. Acta 467, 109--117; Brown, M. F. & Seelig, J. (1978) Biochemistry 17, 381--384; Seelig, J., & Gally, H. U. (1976) Biochemistry 15, 5199--5204] and are shown to agree qualitatively under certain highly restrictive conditions. Under more general conditions, it is shown that many possible solutions are generated but that these may often be separated into a small number of likely conformations in which the head group torsion angles are restricted to specific ranges rather than to a discrete set of values. There is no NMR evidence, however, to support the notion that there are only single conformational solutions to the NMR measurements for the above phospholipid systems.
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PMID:Physical studies of cell surface and cell membrane structure. Determination of phospholipid head group organization by deuterium and phosphorus nuclear magnetic resonance spectroscopy. 51 75

1. The daily water intake of adult Brown Leghorn hens was measured at water temperatures of 0, 10, 20, 30, 40 and 45 degrees C. The electrical activity of neurones in the nucleus ventro-lateralis anterior solitarii (NVLAS) of the medulla was also measured when the mouth was stimulated with water at the same temperatures. 2. There was a significant decrease in water intake when the temperature of the water was 10 or 45 degrees C. 3. There was an increase in activity of some of the NVLAS neurones with decreasing water temperature and this activity was in response to specific "cold" receptors. 4. Some NVLAS neurones were identified which showed an increase in activity at temperatures of 45 degrees C and more; it was concluded that these represented responses to thermal pain. 5. It is concluded that the effects of temperature on water intake may in part be explained by the behaviour of the oral receptors.
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PMID:Effects of water temperature on short-term water intake and medullary neuronal responses in the hen. 54 69

The presence of organochlorinated pesticides in water samples drawn in the Argentine Antarctic Sector and Atlantic coastline has been proved. In general, these samples showed quantities that varied between a few hundredths of a ppmm to slightly more than 1 ppmm, although in some cases and for certain pesticides, depending on the locations, the levels found were definitely higher. With the exception of Dieldrin, which appeared in only one sample/in what would seem to be its course few hundredths of a ppm, to slightly more than 1 ppmm, although in some cases and for certain pesticides found were the same as those reported in previous investigations. The isolated cases of high pesticide contents in water samples drawn at wharves and of snow in the vicinity of Almirante Brown Base show up clearly the influence of human activity on the contamination of the environment.
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PMID:Organochlorinated pesticides in the Argentine Antarctic sector and Atlantic coastline waters. 54 80

The existence of two conformational states of concanavalin A (Con A) with different metal ion binding properties has been recently demonstrated (Brown, R. D., Brewer, C. F., & Koenig, S. H. (1977) Biochemistry 16, 3883). Introduction of Mn2+ to the S1 site and Ca2+ to the S2 site of apo-Con A was shown to induce a conformational change in the protein, ascribed to a cis-trans isomerization of a peptide bond in the secondary structure, which results in extremely tight binding of the metal ions. This induced conformation is referred to as "locked" and the initial conformation as "unlocked". The locked ternary complex is identical with the native protein. In the present paper, we report evidence for the formation of a relatively stable, locked, ternary Ca2+-Con A complex that possesses properties similar to those of native Ca2+-Mn2+Con A. The experimental technique involves measurement of the magnetic field and time dependence of the nuclear magnetic relaxation rate (1/T1) of solvent water protons in solutions of Ca2+-Con A, after the addition of Mn2+ ion which slowly bind to the protein. The kinetic data can be fit by a model for Ca2+ interactions with Con A which indicates that Ca2+, in the absence of Mn2+, can bind at both the S1 and S2 sites of the protein and, furthermore, can induce the protein to undergo the unlocked to locked conformational transition. In terms of this model, the time-dependent binding of the Mn2+ ions is due to replacement of Ca2+ ions at the S1 sites in the locked protein. The off-rate of Ca2+ from the S2 site of the locked ternary Ca2+-Con A complex is much greater than that from the locked Ca2+-Mn2+-Con A complex. From the effects of added alpha-methyl D-mannopyranoside on the rate of replacement of Ca2+ by Mn2+ at the S1 site of the locked ternary Ca2+-Con A complex, it is concluded that the latter complex binds saccharides as strongly as the locked Ca2+-Mn2+-Con A complex. In addition, analysis of the data indicates that apo-Con A in the locked conformation binds alpha -methyl D-mannopyranoside with approximately 7% of the affinity of the fully metallized locked form of the protein. This strong saccharide-binding activity of locked apo-Con A, compared with that of the unlocked apo-Con A, was further demonstrated by equilibration of unlocked apo-Con A with alpha-methyl D-mannopyranoside, which resulted in the formation of the locked apo-Con A-saccharide complex. These results demonstrate that it is the locked conformation of Con A that is primarily responsible for saccharide-binding activity, and that the function of the bound metals is primarily to maintain the protein in the locked conformation.
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PMID:Conformation as the determinant of saccharide binding in concanavalin A: Ca2+-concanavalin A complexes. 70 10

Groups of 48 males and 48 female rats were given diets containing 0 (control), 500, 2000 or 10,000 ppm Chocolate Brown HT for 2 years. These treatments had no adverse effect on mortality, body-weight gain, food or water consumption, haematology, renal function, serum constituents, organ weight or histopathology. From the incidence of tumours observed in the control and test animals it is concluded that Chocolate Brown HT did not exert any carcinogenic effect and that the no-untoward-effect level was 10,000 ppm.
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PMID:Long-term toxicity studies on Chocolate Brown HT in rats. 73 86


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