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Target Concepts:
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Query: UMLS:C0155339 (
Brown
)
12,436
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TMT
(2,5-dihydro-2,4,5-trimethylthiazoline) is known as a component of fox feces inducing fear in rodents. However, no recent chemical analyses of fox feces are available, and few studies make direct comparisons between
TMT
and fox feces. Fox feces from 3 individuals were used to prepare 24 samples to be analyzed for the presence of
TMT
using gas chromatography-mass spectrometry (GC-MS). When
TMT
was added in low amounts (50-2000 nmol/g),
TMT
was detected in 10 out of 11 samples. When no
TMT
was added,
TMT
was detected in only 1 out of 13 samples. In a second experiment, we tested the behavioral response of male
Brown
Norway (BN) and Wistar rats to either fox feces, a low amount of
TMT
(0.6 nmol) or 1-hexanol.
TMT
induced freezing in the rats, but fox feces induced significantly more freezing episodes and longer total duration of freezing in both rat strains. In experiment 3, male BN rats were exposed over several days to fox feces, rat feces, 1-hexanol, cadaverine, 2-phenylethylamine, and
TMT
, one odor at a time. Fox feces induced significantly more freezing episodes of a longer total duration than any of the other odors, with rat feces and 1-hexanol giving rise to the lowest amount of freezing. This finding, together with our inability to verify the presence of
TMT
in fox feces, indicates that the concentration of
TMT
in our fox feces samples was below 50 nmol/g. It may also be that other compounds in fox feces play a role in its fear-inducing properties.
...
PMID:Where is the TMT? GC-MS analyses of fox feces and behavioral responses of rats to fear-inducing odors. 2922 18
