Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent factor-analytic studies involving over 2000 patients have reduced the symptoms of obsessive-compulsive disorder (OCD) into a few dimensions or potentially overlapping syndromes. Hoarding consistently emerged as a separate factor in all these studies. This study investigated the relationship between OCD symptom dimensions and normal personality traits in a sample of 56 OCD patients. They were administered the Sensitivity to Punishment and Sensitivity to Reward Questionnaire and the Eysenck Personality Questionnaire, derived from Gray's and Eysenck's personality models, respectively. The personality scores were correlated with previously identified symptom dimensions from the Yale-Brown Obsessive-Compulsive Scale Symptom Checklist (Y-BOCS-SC), controlling for overall illness severity. High scores on the hoarding dimension of the Y-BOCS-SC were positively correlated with scores on the Sensitivity to Punishment scale and negatively with Eysenck's Psychoticism scale. While high sensitivity to punishment is a personality feature common to many OCD patients, it is more strongly pronounced in patients with hoarding symptoms. These patients also appear to be less impulsive or novelty seeking as reflected by low scores on Eysenck's Psychoticism scale. High sensitivity to punishment and low novelty seeking in OCD hoarders might explain their poor compliance and response to conventional treatments, but this question needs to be explored further in a prospective treatment study.
 ...
PMID:High sensitivity to punishment and low impulsivity in obsessive-compulsive patients with hoarding symptoms. 1557 81

Compulsive shopping is an impulse control disorder that produces psychological distress. Appropriate measurement scales of compulsive buying are important to identify compulsive buyers. Three compulsive buying scales (Faber and O'Guinn scale, Edwards scale, Yale and Brown scale) were tested in an Italian sample composed of 438 participants randomly selected from the general population. Self-report questionnaires measured psychiatric dysfunctions and personality traits. The data confirmed that high anxiety, obsessive-compulsive dysfunctions, depression, psychoticism, and low self-esteem were associated with inappropriate shopping. The Faber and O'Guinn scale and Edwards Scale are appropriate for surveys, while the Yale and Brown scale are more appropriate for clinical diagnosis of psychological dependences.
 ...
PMID:Validation of three compulsive buying scales on an Italian sample. 2340 51