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Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spleen necrosis virus (SNV) and Reticuloendotheliosis virus strain A (REV-A) belong to the family of reticuloendotheliosis viruses and are 90% sequence related. SNV-derived retroviral vectors produced by the REV-A-based D17.2G packaging cell line were shown to infect human cells (H.-M. Koo, A. M. C. Brown, Y. Ron, and J. P. Dougherty, J. Virol. 65:4769-4776, 1991), while similar vectors produced by another SNV-based packaging cell line, DSH134G, are not infectious in human cells (reviewed by R. Dornburg, Gene Ther. 2:301-310, 1995). Here we describe a careful reevaluation of the infectivity of vectors produced from the most commonly used REV-A- or SNV-based packaging cells obtained from various sources with, among them, one batch of D17.2G packaging cells obtained from the American Type Culture Collection. None of these packaging cells produced vectors able to infect human cells. Thus, contrary to previously published data, we conclude that REV-based vectors are not infectious in human cells.
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PMID:Avian reticuloendotheliosis virus strain A and spleen necrosis virus do not infect human cells. 1059 Jan 42

This paper reports an enzootic outbreak and spontaneous regression of keratoacanthomas among adult layer hens with lesions on the skin of the legs. The observations were performed in a flock of 55,000 commercial layers (50,000 Lohmann White and 5,000 Lohmann Brown). At the age of 30 weeks, Lohmann White layers exhibited a number of growths (at an average of 60 hens per week, representing 0.1% of the flock) in the region of leg toes on a daily basis over 28 weeks that regressed during the remaining flock production period. Gross and histological investigations identified the lesions as keratoacanthomas. PCR analysis was negative for avian leukosis virus (ALV) and reticuloendotheliosis virus (REV). The present investigations have revealed an unusual case: this is the first report on an enzootic outbreak of multiple keratoacanthomas in commercial layers. The results of the aetiological investigations do not show a relation to any infectious agent or a chemical-toxic cause. The abnormal invasion of keratinocytes from the stratum corneum leading to neoplasms in this case coincides with the phase of peak laying capacity which is in fact a stress factor and might be regarded as a provocative moment.
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PMID:Enzootic outbreak and spontaneous regression of keratoacanthomas in a commercial layer flock. 2392 48

(1) Background: Dermanyssus gallinae, a hematophagous ectoparasite, adversely affects the health status of laying hens, leading to reduced egg production and significant economic losses in commercial farms. The aim of this study was to determine the effect of D. gallinae on the development of post-vaccination immune responses in layer hens. (2) Methods: A total of 80 blood samples were collected at four time-points (B1-B4) from 10 Hy-Line Brown hens, randomly selected from a commercial layer farm. The flock was naturally infested with D. gallinae and treated twice with Biobeck PA 910 (AI silicon dioxide). The samples were collected before and after each treatment. The percentages of IgM+ B cells, CD3+/CD4+ T cells and CD3+/CD8a+ T cells were determined by flow cytometry; the titres of antibodies against avian encephalomyelitis, infectious bronchitis virus, Newcastle disease virus, Ornithobacterium rhinotracheale, reticuloendotheliosis virus and avian reovirus were determined by the immunoenzymatic method. (3) Results: The percentage of Th cells and post-vaccination anti-IBV and anti-NDV antibodies decreased significantly at the second infestation peak when the number of parasites was twice higher than at the first infestation peak. Non-significant negative correlations were found between the number of mites and the percentage of B cells (R = -0.845, p > 0.05) and between the number of mites and the percentage of Th cells (R = -0.522, p > 0.05), and a significant positive correlation was noted between the number of mites and the percentage of Tc cells (R = -0.982, p < 0.05). There were non-significant correlations between the number of mites and antibody titres. (4) Conclusion: The present findings suggested that D. gallinae might inhibit immune responses since the percentages of B cells and Th cells were negatively correlated with the number of mites. The percentage of Tc cells was positively correlated with the number of mites, which indicated that D. gallinae could stimulate cellular immune responses in infested laying hens. However, further research is needed to determine whether D. gallinae suppresses the production of vaccine-induced antibodies.
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PMID:Changes in the Percentages of B- and T-Lymphocytes and Antibody Titres in Laying Hens Infested with Dermanyssus gallinae-A Preliminary Study. 3251 4