Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immune complexes occur spontaneously in the testis of Brown-Norway (BN) inbred rats between the basal lamina of the seminiferous tubules and the outer lamina of the myoid testicular cells. The deposits can be detected immunohistologically (IgG; C3) and by electron microscopy. The immune complexes appear between the 8th and 12th weeks of life, increase in amount up to the 30th week and decrease thereafter. After about the 20th week, of life, 15% of the animals show destruction of the germinal epithelium accompanied by an infiltration of lymphocytes and plasma cells. The final stage of this disease, which initially shows no signs of inflammation, is characterized by diffuse tubular atrophy. However, up to the 70th week of life, 85% of the animals with immune complexes show no pathological alterations. Antibodies eluated from the testes react with spermatocytes I and structures close to the lumen of the seminiferous tubules, but not with mature sperms. Serum antibodies to sperms occur in about 25% of the BN rats, but the presence of these antibodies shows no correlation with the immunohistological findings. This newly described spontaneous immune complex orchitis is regarded as a further example of an in-situ-induced immune complex disease. The observations made here can be compared with those in (peri-) membraneous glomerulonephritis, another example of a disorder resulting from in-situ-formation of immune deposits.
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PMID:Spontaneous immune complex orchitis in brown Norway rats. 256 48

Chronic serum sickness (CSS) with systemic immune complex deposition has been produced in female Fischer (F344) rats by the daily intravenous (i.v.) administration of 2.0 mg bovine serum albumin (BSA) (Arisz et al., 1979). In the experiments described below, daily i.v. doses ranging from 0.5 to 10.0 mg BSA were found to be effective in producing CSS in F344 strain rats. The severity of renal disease and the extent of extrarenal immune complex deposition were increased with higher daily doses of BSA. Daily administration of different doses of BSA by an intraperitoneal (i.p.) route resulted only in slight mesangial glomerular abnormalities and did not cause abnormal elevation of urinary protein excretion. At the same time, extrarenal accumulation of immune deposits similar to that observed in rats given BSA by the i.v. route was seen. Wistar and Lewis (LEW) strain rats were similar to F344 strain rats in susceptibility to the induction of CSS, but daily i.v. injection of 2.0 mg BSA failed to produce the disease in Brown Norway (BN) rats. The latter observation suggests that genetic differences may influence the expression of immune complex disease in this model.
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PMID:Chronic serum sickness in the rat: influence of antigen dose, route of antigen administration and strain of rat on the development of disease. 646 59

To date, pathology characteristics of toxic oil syndrome (TOS), a disease associated with consumption of a contaminated cooking oil in Spain in 1981, have not been reproduced in an animal model. As vasculitis, eosinophilia, and a rise in circulating IgE levels were features of the acute phase of TOS, leading to an autoimmune outcome, a review of predisposition to these aspects across species was conducted. The intent was to determine predisposed strains or species that potentially might be effective in testing the toxic oils and thus defining the precise identity of the toxic contaminant(s). A number of potential candidates emerge from this review. Among mice, these include the NZB mouse hybrids, the MRL/lpr and SJL/J strains, and a transgenic mouse model of eosinophilia. The Brown Norway may be the most appropriate rat strain, while beagle dogs inbred to be genetically predisposed to immune complex disease and vasculitis are also a candidate species. Of the more exotic species, the mink and ferret have characteristics that might make them suitable candidates for testing oil samples.
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PMID:A search for an animal model of the Spanish toxic oil syndrome. 1217 82