Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prion-related diseases are accompanied by neurodegeneration, astroglial proliferation and formation of proteinase K-resistant aggregates of the scrapie isoform of the prion protein (PrPSc). The synthetic PrP fragment 106-126 was reported to be neurotoxic towards cultured rat hippocampal neurons (Forloni, G., Angeretti, N., Chiesa, R., Monzani, E., Salmona, M., Bugiani, O. and Tagliavini, F. (1993) Nature 362, 543-546) and mouse cortical cells (Brown, D.R., Herms, J. and Kretzschmar, H.A. (1994) Neuroreport 5, 2057-2060). However, we found the viability of these and other neuronal cell types not to be impaired in the presence of PrP106-126 under widely varied sets of conditions. Aged preparations of the peptide as well as synthetic deamidated and isomerized derivatives that correspond to the aging products of the peptide proved also to lack neurotoxicity. Apparently, PrP106-126 cannot serve as a model for the interaction of PrP with neuronal cells.
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PMID:Neurotoxicity of prion peptide 106-126 not confirmed. 1064 43

US-American philosopher Norman O. Brown (1913-2002) was one of the very few twentieth-century intellectuals to situate hermaphroditism at the core of their work. Although Brown's publications became cult books of the then emerging protest subcultures and were eventually regarded as milestones in the history of Freudian revisionism, the reception of his views on hermaphroditism has been insubstantial. The present contribution focuses at first on Brown's attempt to supersede binary sexuality and its same-sex/other-sex combinatories by positing an ambit of hermaphroditic reconciliation that emerges from the depths of the unconscious, but is effectual only as an eschatological ideal. Against this backdrop, Brown's consequential neglect of Charles Darwin's universalization of corporeal hermaphroditism and of Magnus Hirschfeld's conception of human sexual intermediariness are analyzed and assessed.
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PMID:LOVE'S BODY AND THE BODY OF LOVE: On Norman O. Brown's Eschatological Hermaphrodite and the Darwinian Continuities of Nature. 3302 Nov 59