Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0155339 (Brown)
 12,436 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Language development of five two-year-old hearing children of deaf parents was studied longitudinally. These results were compared with the normal language developmental literature, and analyzed in relation to the form of the mothers' oral input. Three of the deaf mothers were less than 15% intelligible and their MLU was less than 2.0. The children spent less than 20 hours weekly with normal speakers. Frequency and proportion measurements were used to compare these children's utterances with those of children from normal-hearing households studied by Lois Bloom and Roger Brown. The observed children's utterances contained similar categories of semantic-syntactic relations and as many syntactic utterance types as children from hearing households. Furthermore, the children were appropriately acquiring grammatical morphemes in relation to their MLU. The overwhelming majority of the children's utterances adhered to a subject-verb-object order of constituents, and discourse interaction (the ability to add information to another's utterance) was developing. The results indicate that children, when cognitively ready, need little exposure to the normal model language to learn to speak during the early stages of development.
 ...
PMID:The influence of deviant maternal input on the development of language during the preschool years. 50 16

Topic continuing and nontopic continuing utterances produced by three productively language-disordered preschoolers were examined. All children were intellectually, normal, exhibited multiple articulation errors, and produced utterances characteristic of children in Brown Stage I. Each child and mother participated in a videotaped 40-min free play activity. Communicative behavior emitted by mothers and children was transcribed using procedures described by Bloom, Rocissano, and Hood (1976). Subsequently, all intelligible child utterances produced adjacent to a maternal utterance were coded as imitative (maintained topic but added no new information), contingent (maintained topic and added new information), and noncontingent (changed topic). Results suggested that these productively disordered children produced a proportion of adjacent utterances comparable to proportions previously reported for children with normal production language skills (Bloom, Rocissano, and Hood, 1976). Further analysis suggested that these productively delayed children relied on an imitation strategy to continue conversational exchanges. Results are discussed in terms of intervention procedures suitable for children displaying conversational deficits, particularly the impact of phonological delay on conversational exchanges.
 ...
PMID:The topical relationship among adjacent utterances in productively delayed children's language addressed to their mothers. 395 74

The presence of immunoreactive bombesin in a human lung small-cell carcinoma grown in nude mice was established by several criteria: (i) Radioimmunoassay of tissue extracts for bombesin revealed approximately 6.5 pmol/g of tissue; (ii) bombesin was found in 12-14% of the tumor cells by immunohistochemical localization; (iii) gel filtration of small-cell carcinoma extract on Sephadex G-75 and Bio-Gel P-4 gave only a single peak of immunoreactivity, which occurred at the elution volume of bombesin; and (iv) reverse-phase HPLC of acid-solubilized extracts separated the immunoreactive material into three discrete peaks, one of which eluted with a retention time identical to that of synthetic bombesin. The presence of bombesin may represent the ectopic expression of this peptide in small-cell carcinoma, because immunoreactive bombesin was found in human fetal and neonatal lung but apparently not in adult lung tissue [Wharton, J., Polak, J. M., Bloom, S. R., Ghatei, M. A., Solcia, E., Brown, M. R. & Pearse, A. G. E. (1978) Nature (London) 273, 769-770]. The immunoreactive bombesin previously found in mammalian tissues is considerably larger than amphibian bombesin; these data substantiate the presence of a mammalian form of bombesin in a human tumor that may have a structure similar to that of the amphibian peptide.
 ...
PMID:Human lung small-cell carcinoma contains bombesin. 628 81

Divorce and separation introduce extensive changes in the lives of married mothers. Their role as wife ends and, without the economic and social supports afforded by the marital institution, their role as mother is disrupted (Kohen, Brown, and Feldberg 1979). In turn they become heads of their families, a role discontinuous both with their socialization and marital experience and with the structure of their access to respect, status, jobs, and income from public institutions. Previous reports have emphasized the former changes-those which result from the loss of marriage (Bloom, White, and Asher 1979). Little attention has been devoted to the implications of changes demanded by the organization of post-divorce life. The contention of this study is that both must be considered in understanding the social and emotional consequences that follow the break-up of marriage. This paper focuses on them as dimensions within a general model of role change. The analysis assumes that roles provide the organizational bases for self-identity (Brim 1960; Turner 1978) and therefore, that self-identity will reflect the institutional patterns and personal experiences that are incorporated within the process of role change. Divorce is treated as an event occurring within the transition from married motherhood to single parenthood.
 ...
PMID:From wife to family head: transitions in self-identity. 726 62

Neurotensin, originally isolated from the bovine hypothalamus (Carraway and Leeman 1973) is found not only in several parts of the brain (Carraway and Leeman 1976a) but also in the lower intestine (Orci, Baetens, Rufener, Brown, Vale and Guillemin 1976). Although neurotensin has a wide range of pharmacological effects (Carraway, Demer and Leeman 1976b), the concentrated localization of this peptide in the gut suggests that neurotensin may play a pathophysiological role in the gut disease. Recently, Bloom, Blackburn, Ebeid, Ralphs and Polak (1978) proposed the hypothesis that neurotensin may play an important role in the pathogenesis of dumping syndrome, based on measurement of plasma neutrotensin levels in gastrectomized patients. To examine the hypothesis, we compared changes of plasma neurotensin levels after 50 g OGTT in total gastrectomized patients with those in control subjects. In this paper, we report on enhanced neurotensin like immunoreactivity (NTLI) release in gastrectomized patients after 50 g OGTT.
 ...
PMID:Enhanced neurotensin-like immunoreactivity release in total gastrectomized patients after 50 g OGTT. 743 80

Many health care professionals all over the world have been taught neonatal cardiopulmonary resuscitation (CPR) using the neonatal CPR course based upon the work of Bloom and Cropley. The purpose of this article is to provide a retrospective review of the development of some of the neonatal CPR techniques, to discuss current techniques and to complement the dedication of this issue to Dr. Ronald Brown and Catherine Copley, MN, RN.
 ...
PMID:Neonatal cardiopulmonary resuscitation: the good news and the bad. 965 38