Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0154251 (lipid disorder)
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Human Gene/Protein
Cytochrome b5 reductase 3 15.3
Mitochondrial trans-2-enoyl-CoA reductase 14.3
copine 6 13.7
hydroxysteroid (17-beta) dehydrogenase 4 13.3
ATP binding cassette transporter 1 12.4
Acyl-CoA synthetase 4 12.3
SPACA3 12.1
BTNL3 11.8
PAHX 11.8
HSD3B7 11.6
mitochondrial 3-oxoacyl-CoA thiolase 11.4
LIM domain containing 2 11.4
MECR 11.4
SLC35C1 11.1
ACAA2 11.1
ATP-binding cassette transporter-1 11.0
HVCN1 11.0
ACAA1 11.0
CD69 molecule 10.8
BSP1 10.8
phytanoyl-CoA 2-hydroxylase 10.6
NEPH1 10.4
CPT II 10.3
fatty acid omega-hydroxylase 10.2
voltage-dependent anion channel 2 10.2
ROMO1 10.0
Triacylglycerol lipase 10.0
CPT2 9.9
APM1 9.9
CYP4F 9.9
type II iodothyronine deiodinase 9.9
CYP4F3 9.9
PAQR3 9.8
DNL 9.7
HLP 9.6
HADHA 9.5
protocadherin 15 9.5
ALDH3A2 9.5
nuclear receptor subfamily 4 9.4
sterol regulatory element binding protein-2 9.4
more...
Disease
lipid disorder 15.3
Peripheral and visceral atherosclerosis 15.3
Disorders of mitochondrial metabolism 13.3
Tendon xanthoma 13.0
Familial combined hyperlipidemia 12.9
FHBL2 12.5
Jordan's anomaly 12.1
Combined hyperlipidemia 11.5
Hyperapobetalipoproteinemia 11.0
hypolipoproteinemia 11.0
arcus senilis 10.8
Hepatobiliary disease 10.6
Type V hyperlipoproteinemia 10.6
familial hypertriglyceridemia 10.4
Homozygous familial hypercholesterolemia 10.2
Familial defective apolipoprotein B-100 10.2
Heterozygous familial hypercholesterolemia 9.8
Familial hypercholesterolemia 9.8
anthracosilicosis 9.7
lipoprotein disorder 9.6
LCAT deficiency 9.6
Conduction disorders 9.5
HLP 9.4
hyperchylomicronemia 9.4
arteriolitis 9.3
back disorder 9.2
lipoproteinemia 9.2
menopausal syndrome 9.0
KAR 9.0
Peritoneal fibrosis 8.9
Refsum disease 8.8
hyperlipoproteinemia 8.8
Type III hyperlipoproteinemia 8.7
aortic sclerosis 8.7
alcoholic ketoacidosis 8.7
xanthomatosis 8.7
FED 8.6
sphingolipidosis 8.6
Tangier disease 8.6
Wolman disease 8.5
more...
Symptom
Intermenstrual bleeding 10.3
left upper quadrant pain 8.3
aphagia 7.7
dark urine 7.2
Burning 7.0
Physical findings 6.9
exertional angina 6.7
otalgia 5.3
hepatosplenomegaly 5.2
hot flushes 5.0
myalgia 4.9
angina 4.4
fever of unknown origin 4.3
sore throat 3.9
hoarseness 3.8
splenomegaly 3.6
weakness 3.5
overweight 3.4
dysarthria 3.4
dystonia 3.3
myoclonus 3.2
chest pain 2.8
hepatomegaly 2.8
hypotonia 2.8
abdominal pain 2.7
flushing 2.6
spasticity 2.6
vomiting 2.3
regurgitation 2.3
constipation 2.0
nausea 1.8
back pain 1.7
starvation 1.7
anorexia 1.5
collapse 1.5
ataxia 1.3
discomfort 0.8
discomfort 0.7
fatigue 0.6
dyspnea 0.5
more...
Drug
Lescol 10.2
Lescol 9.9
Femara 9.4
Cremophor RH40 9.1
Lipitor 8.9
Lipitor 8.5
Lipitor 8.5
Methylcellulose 8.4
NAH 8.3
metformin hydrochloride 8.3
Gemfibrozil 7.9
Isradipine 7.3
Nimesulide 7.1
Copaxone 7.0
Pravastatin 6.6
Ezetimibe 6.5
Moxifloxacin 6.4
Singular 6.3
AIC 6.3
Raloxifene 5.8
DEX 5.5
niacin 5.0
Lovastatin 4.9
GEO 4.7
ROS 4.2
Glycerol 4.1
EPA 4.1
Silica 4.1
HCG 3.9
Alanine 3.8
ALA 3.8
Bifidobacterium 3.8
Vitamin E 3.6
Retinoic acid 3.6
Kenyan 3.5
vitamin E 3.5
Portal 3.3
PCB 3.2
Adriamycin 3.1
Albumin 3.1
more...
Enzyme
phosphoethanolamine N-methyltransferase 10.0
KAR 8.9
gluconate dehydrogenase 8.8
phospholipid methyltransferase 8.7
sterol carrier protein 8.4
glycogenin 8.1
fatty-acid synthase 8.0
proprotein convertase 8.0
CYP7A1 7.9
acrosin 7.9
fatty acid elongase 7.3
lipoprotein lipase 7.3
LPL 7.2
iodothyronine 5'-deiodinase 7.2
phospholipid hydroperoxide glutathione peroxidase 6.8
ACAT 6.8
PMT 6.6
lecithin:cholesterol acyltransferase 6.6
acetyl-CoA carboxylase 6.6
CPT 6.6
galactocerebrosidase 6.6
ALDH 6.5
AMP-activated kinase 6.4
AMPK 6.1
1-hydroxylase 6.1
methionine adenosyltransferase 5.9
AMP deaminase 5.9
fatty acid desaturase 5.8
acyl-CoA dehydrogenase 5.8
subtilisin 5.8
acyl-CoA dehydrogenase 5.7
paraoxonase 5.6
AMP-activated protein kinase 5.5
diacylglycerol acyltransferase 5.5
cholesterol esterase 5.4
acyl-CoA oxidase 5.4
cholesterol acyltransferase 5.3
paraoxonase 5.3
furin 5.2
soluble epoxide hydrolase 5.2
more...
Compound
Isofraxidin 11.0
Sennoside A 10.8
Desmosterol 9.8
Tributyrin 9.6
Tartar 9.3
merocyanine 540 9.1
Phytanic acid 9.0
cholest-5-ene 8.9
Dioscin 8.7
Dioscin 8.7
Ginkgolide B 8.6
Asiatic acid 8.4
Cyanate 8.3
TBHQ 8.0
CPIB 7.9
Pyridostigmine 7.9
7beta-hydroxycholesterol 7.8
Filipin 7.7
Tetramethylpyrazine 7.6
Lopinavir 7.6
cis-vaccenic acid 7.5
11,12-EET 7.5
Allicin 7.5
Matrine 7.4
Matrine 7.4
Matrine 7.4
Allyl isothiocyanate 7.3
dimethyl methylphosphonate 7.2
Doxazosin 7.1
Oil Red O 7.1
Fenofibrate 7.0
Phlorizin 7.0
Perfluorooctanoic acid 7.0
Etretinate 6.9
Microcystin-LR 6.8
butyryl-CoA 6.8
Oil Red O 6.8
Carnitine 6.7
PMT 6.6
Ritonavir 6.6
more...