Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0154059 (Esophagus)
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Human Gene/Protein
zinc finger protein 207 13.4
N-myristoyltransferase 2 11.8
squamous cell carcinoma antigen 2 11.4
MAGE-D4 10.4
cysteine dioxygenase type 1 10.1
BRAVO 9.8
C20orf54 9.8
claudin 18 9.5
LDOC1 9.2
annexin A10 9.2
KE4 9.1
ECRG2 9.1
fragile histidine triad gene 8.9
CDO1 8.9
HGD 8.4
TMIE 8.4
HPP1 8.4
Protein kinase D1 8.4
POU3F3 8.3
IMP1 8.2
adenomatosis polyposis coli 8.0
POD1 8.0
PABP2 7.9
CEA mRNA 7.8
phospholipase C epsilon 1 7.8
excision repair cross-complementing 1 7.7
POLB 7.7
DRC1 7.7
Eosinophil-derived neurotoxin 7.6
KRT16 7.6
TEF 7.6
EMP1 7.5
lok 7.5
CBR3 7.5
stem cell growth factor 7.5
DSC2 7.5
POEM 7.5
COL4A6 7.4
GIF 7.4
Gamma-glutamyltransferase 7.4
Astrin 7.4
Eosinophil peroxidase 7.3
cyclin G2 7.3
FAT4 7.3
CDH11 7.3
proton pump 7.1
OPRT 7.1
SEC3 7.1
EMS1 6.9
ribosomal protein L3 6.9
DYS 6.9
JAM-C 6.9
GRP1 6.9
MOR1 6.8
T-synthase 6.8
P73 6.8
SEC1 6.8
UBR1 6.7
PTPRD 6.7
Acidic fibroblast growth factor 6.7
CTGF protein 6.7
secreted frizzled-related protein 1 6.7
squamous cell carcinoma antigen 6.6
ZNF217 6.6
DCI 6.6
ABCC5 6.6
Lipocalin 2 6.6
CD3-epsilon 6.6
neural Wiskott-Aldrich syndrome protein 6.6
IL12A 6.5
DOCK8 6.5
FOXF1 6.5
C30 6.4
CENPF 6.4
aldehyde dehydrogenase 1A1 6.4
SPRY4 6.4
Doublecortin-like kinase 1 6.3
IT1 6.3
RPA1 6.3
CHEK1 6.3
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Disease
Esophagus 13.4
Esophagus 13.4
Malignant esophageal stricture 13.4
NEPPK 12.4
Pangastritis 12.4
Esophageal 12.2
stage I esophageal cancer 12.1
Esophageal GIST 11.8
Nutcracker esophagus 11.8
Esophageal leiomyoma 11.3
Esophageal anastomotic leak 11.1
Drug-induced esophagitis 11.1
Esophageal atresia/tracheoesophageal fistula 11.1
recurrent esophageal cancer 10.5
Erosive esophagitis 10.5
Hypopharynx 10.5
Anterior spinal artery syndrome 10.4
Generalized morphea 10.4
metastatic esophageal cancer 10.4
pyloric dysfunction 10.1
Esophageal rupture 9.9
connective tissue cancer 9.9
Schatzki's ring 9.8
postvagotomy syndrome 9.7
Dysphagia lusoria 9.7
esophageal cancer 9.6
esophageal cancer 9.5
Eosinophilic esophagitis 9.5
Reflux esophagitis 9.5
esophageal stricture 9.3
achalasia 9.2
Human papilloma virus infection 9.2
Recurrent laryngeal nerve palsy 9.2
Barrett's esophagus 9.2
esophageal spasm 9.2
Self-induced vomiting 9.2
esophageal dysmotility 9.1
paraesophageal hernia 9.1
Boerhaave's syndrome 9.0
Multiple cancer 8.9
Leiomyomatosis 8.9
Esophageal perforation 8.9
esophageal web 8.9
Alkaline reflux gastritis 8.9
Recurrent cancer 8.8
Esophageal adenocarcinoma 8.8
megaesophagus 8.7
pharyngolaryngitis 8.7
herpes esophagitis 8.7
Heller 8.7
Plummer-Vinson syndrome 8.7
Esophageal tuberculosis 8.6
recurrent laryngeal cancer 8.6
Zenker's diverticulum 8.6
esophageal atresia 8.6
gastroesophageal reflux disease 8.4
esophagitis 8.4
hiatal hernia 8.4
carcinoma of the esophagus 8.4
Esophageal squamous cell carcinoma 8.4
Laryngopharyngeal reflux 8.2
reflux esophagitis 8.2
Vagina 8.2
Brunner's gland hyperplasia 8.0
dysphagia 8.0
aerophagia 7.9
duodenal polyp 7.8
Vagina 7.8
Vulva 7.8
Chemoradiation 7.8
Gastric perforation 7.7
gastrointestinal reflux 7.7
SMA II 7.7
Basaloid squamous cell carcinoma 7.6
premalignant condition 7.6
Lymphatic metastasis 7.4
chronic pharyngitis 7.3
Trachea 7.3
Trachea 7.3
Johanson-Blizzard syndrome 7.3
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Symptom
Tongue fasciculations 11.1
Throat symptoms 10.2
Globus sensation 9.9
painful swallowing 8.9
heartburn 8.9
ENT symptoms 7.9
Regurgitation 7.9
belching 7.9
acid regurgitation 7.6
aphagia 6.8
regurgitation 6.6
bradypnea 5.7
aphonia 5.4
chest pain 5.4
retching 5.3
bloating 5.3
Gastrointestinal symptoms 5.2
hoarseness 5.2
Poor sleep 4.9
Respiratory symptoms 4.5
chronic cough 4.4
sore throat 4.3
epigastric pain 4.2
stridor 4.2
Fluctuation 4.2
atypical chest pain 4.1
Wind 4.0
colic 3.8
abdominal discomfort 3.6
cough 3.6
vomiting 3.3
tingling 3.1
discomfort 2.9
cachexia 2.9
paresis 2.9
acidity 2.8
discomfort 2.8
acute abdomen 2.8
wheezing 2.8
nausea 2.7
shortness of breath 2.6
overweight 2.6
incoordination 2.6
cyanosis 2.5
nausea and vomiting 2.5
anorexia 2.5
rhinorrhea 2.2
dyspnea 2.2
constipation 2.1
abdominal pain 2.1
asthenia 2.0
ENT 2.0
respiratory distress 1.9
erythema 1.7
ophthalmoplegia 1.7
spasm 1.5
pain 1.5
anesthesia 1.5
analgesia 1.2
fatigue 1.2
diarrhea 1.2
insomnia 1.0
hunger 0.9
lethargy 0.9
back pain 0.8
hemoptysis 0.8
flushing 0.8
sleepiness 0.8
arthralgia 0.6
dizziness 0.2
weakness -0.2
stigma -0.3
exhaustion -0.3
collapse -0.4
ataxia -0.6
hypothermia -0.7
headache -2.4
seizures -2.9
Drug
Sivelestat sodium hydrate 9.8
Sivelestat 8.8
Histalog 8.5
Polaprezinc 8.4
EVM 8.3
Histalog 8.3
Lugol 8.1
Lugol's solution 8.0
CEG 7.9
CEG 7.7
BOTOX 7.0
Tenoxicam 6.4
Lipidex 5.8
Flavopiridol 5.7
Mitomycin-C 5.7
Sodium alginate 5.5
Omeprazole 5.4
Propidium 5.4
Areca 5.3
Nimesulide 5.2
Cisapride 5.0
Botox 4.7
Gastro 4.6
CSI 4.5
Digenea 4.1
Digitalis 4.1
Triad 4.1
Triad 4.0
Paraffin 3.9
Erlotinib 3.8
Irinotecan 3.7
Photofrin 3.6
Cetuximab 3.5
Gefitinib 3.2
Vitamin B12 3.1
CoCl2 3.1
CoCl2 3.1
Methylene blue 3.1
CTA 2.9
Prednisolone 2.9
Simvastatin 2.7
Docetaxel 2.6
Herceptin 2.2
Ouabain 2.1
Indomethacin 1.8
HCH 1.6
PCP 1.5
Glucagon 1.5
Fluorescein 1.5
niacin 1.5
ROC 1.5
p75 1.5
Spectrum 1.5
ENT 1.3
ABC 1.3
Albumin 1.2
Glutathione 1.0
Histamine 1.0
ascorbate 0.9
CAM 0.9
vitamin E 0.3
citric acid 0.1
Leaf -0.0
Asthma -0.3
Gel -0.5
caffeine -1.0
Monit -1.7
lysine -2.4
Dermatol -4.6
Enzyme
homoserine kinase 6.4
matriptase 4.9
dihydropyrimidine dehydrogenase 4.7
dihydropyrimidine dehydrogenase 4.7
matriptase 4.4
thymidine phosphorylase 4.4
TRS 4.4
thromboxane synthase 4.3
CDH 4.2
AGT 3.8
MCS 3.8
microsomal epoxide hydrolase 3.8
sucrase-isomaltase 3.6
DCF 3.5
sucrase 3.2
chymase 3.0
neutrophil elastase 3.0
LPL 3.0
tryptase 3.0
aldehyde dehydrogenase 2.9
aldehyde dehydrogenase 2.9
aldehyde dehydrogenase 2.9
aldehyde dehydrogenase 2.6
AOR 2.6
thymidylate synthase 2.6
aldehyde dehydrogenase 2.3
PDK1 2.3
matrix metalloproteinase 2 2.2
pepsin 1.9
reverse transcriptase 1.6
enolase 1.5
PCP 1.5
NADPH-diaphorase 1.5
MMP 1.3
transcriptase 1.2
transglutaminase 1.2
invertase 1.1
DNA methyltransferase 1.1
PARP 0.7
caspase-8 0.7
urease 0.6
NOS 0.6
urease 0.5
NO synthase 0.5
guanylate cyclase 0.3
ERK 0.3
gamma-glutamyl transpeptidase 0.3
elastase 0.2
alcohol dehydrogenase 0.2
glutathione reductase 0.2
caspase-3 -0.1
phospholipase A2 -0.4
APC -0.6
DNA polymerase -0.7
RNA polymerase -0.7
ACE -0.8
catalase -0.8
creatine kinase -0.8
mitogen-activated protein kinase -0.8
trypsin -1.0
peroxidase -1.0
glutathione peroxidase -1.0
acetylcholinesterase -1.4
ATPase -1.6
thrombin -1.6
protein kinase -1.9
focal adhesion kinase -2.0
alkaline phosphatase -2.1
protein kinase C -2.2
superoxide dismutase -2.4
Compound
Benazepril 7.3
D 3 6.9
DCI 6.6
APO 6.2
Paeonol 6.0
OMPA 5.9
barium 5.7
Triamcinolone 5.5
Ephedrine 5.3
TNM 5.3
Montelukast 5.2
Paeoniflorin 5.2
Omeprazole 5.1
TEG 5.0
Cisapride 5.0
MME 5.0
PPI 5.0
DES 4.9
TBE 4.8
Sumatriptan 4.8
Terbutaline 4.8
SCC 4.7
CBDCA 4.5
CBDCA 4.5
Buspirone 4.5
Alginate 4.4
BHC 4.4
Tetrahydrocannabinol 4.3
Baclofen 4.2
Deoxyribonucleic acid 4.1
Ach 4.1
CDH 4.1
ACNU 4.1
DEN 4.0
Apigenin 3.8
DCA 3.8
DCA 3.8
DOP 3.8
malonic acid 3.7
SITS 3.6
MAL 3.6
Celecoxib 3.5
5-FU 3.4
Eosin 3.4
Hypo 3.4
A 71 3.3
HCI 3.2
HEPES 3.1
Eosin 3.1
Risperidone 3.1
Luminal 3.1
Statin 3.1
Hematoxylin 3.1
DIC 3.0
MCH 3.0
Docetaxel 3.0
Formal 3.0
Prednisolone 2.9
COX 2.8
VP-16 2.8
folinic acid 2.7
MMA 2.7
Flux 2.6
Methylene blue 2.5
Estrogen 2.5
PGD2 2.5
DOCA 2.5
Piper 2.4
ITP 2.4
TXA2 2.3
Fibrin 2.3
MMA 2.2
DDP 2.1
Ouabain 2.1
Thromboxane 2.1
Vimentin 2.1
MTS 2.0
Fibrinogen 2.0
MMC 2.0
Nifedipine 1.9
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