Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
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Query: UMLS:C0154059 (
Esophagus
)
2,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Several biomarkers of esophageal squamous cell carcinoma (ESCC) have been explored to improve the prognosis of this disease. One of these, the 47-kDa heat shock protein (
HSP47
), has been screened as a potential biomarker by genomic profiling and is known to be overexpressed in some malignant diseases. In this study, we explored the role and evaluated the prognostic value of
HSP47
expression in ESCC. The function of this protein was analyzed by assaying proliferation, wound healing, and colony formation in an
HSP47
-knockdown ESCC line. The prognostic implication of
HSP47
expression was analyzed by immunohistochemical staining in 157 surgical specimens.
HSP47
expression level and other clinical variables were analyzed using multivariate Cox proportional hazards models. Silencing of the
HSP47
gene in the ESCC cell line inhibited cell proliferation and colony formation.
HSP47
was highly expressed in ESCC tissue samples, compared with normal esophageal tissues. The level of immunohistochemical staining of
HSP47
and pathologic stage were significantly correlated with overall and recurrence-free survival, as shown by multivariate analysis (P = 0.014 and 0.044, respectively). We found that overexpression of
HSP47
is associated with poor prognosis in patients with ESCC and that this is consistent with the function of
HSP47
in terms of increased cell proliferation and colony formation. These results suggest that
HSP47
is a potential prognostic biomarker for ESCC and merits further research for novel diagnostic and therapeutic applications.
Dis
Esophagus
2016 Oct
PMID:Overexpression of HSP47 in esophageal squamous cell carcinoma: clinical implications and functional analysis. 2595 18
