Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0153690 (bone metastases)
 6,382 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
protein FAM134A 11.3
minichromosome maintenance 9 11.3
PALM2 10.7
NSUN6 10.7
MFAP3L 10.7
C6orf167 10.7
STIP1 protein 10.3
SFT2D2 10.0
Cell surface glycoprotein 10.0
Kallikrein-related peptidase 4 10.0
OATP5A1 9.5
proline/arginine-rich end leucine-rich repeat protein 9.3
aldehyde dehydrogenase 1A3 9.0
Microfibrillar-associated protein 5 9.0
MAGEA2 9.0
neural cell adhesion protein 8.8
LLGL2 8.7
KRT23 8.7
ALDH3B2 8.6
NIP7 8.6
killer-specific secretory protein of 37 kDa 8.5
Ral guanine nucleotide exchange factor 8.5
KCNS1 8.5
MYOF 8.5
ATL2 8.5
lymphocyte-specific protein 1 8.4
SCN7A 8.4
FAM84B 8.4
NUP155 8.3
bone-type alkaline phosphatase 8.3
PLCB3 8.3
MPC3 8.2
DEP domain containing 1 8.2
STEAP2 8.2
KHDRBS1 8.1
ADAMTS14 8.1
Bone morphogenetic protein 7 8.0
GYPC 8.0
parathyroid hormone-related protein 8.0
CA15 8.0
PAIRBP1 8.0
RANK 7.9
MAPK12 7.9
Frizzled-5 7.9
Endomucin 7.9
CHRDL1 7.8
CLL1 7.8
MDP 7.8
ARID4A 7.8
Hepatocyte growth factor receptor 7.8
c-src tyrosine kinase 7.7
SH3-domain binding protein 2 7.7
special AT-rich sequence binding protein 1 7.6
SPAP 7.6
mH2A1 7.6
FBXL4 7.6
Cadherin-11 7.6
HOXB9 7.6
TNRC9 7.5
ROBO4 7.5
PDGFC 7.5
pulmonary surfactant apoprotein 7.5
Zinc finger E-box binding homeobox 1 7.5
ERG-associated protein with SET domain 7.4
STEAP3 7.4
TEAD2 7.4
STIP1 7.4
MAGE3 7.4
prostate-specific membrane antigen 7.4
WISP-1 7.4
CEACAM8 7.4
PSMA 7.3
OGN 7.2
MRC2 7.2
PDGFD 7.2
SK3 protein 7.2
prostatic acid phosphatase 7.2
DKK2 7.2
Plexin-B1 7.2
transforming growth factor beta receptor II 7.2
more...
Disease
Stage IV Prostate Adenocarcinoma 12.3
bone metastases 12.3
Thoracic neuroblastoma 12.3
Desmoplastic mesothelioma 11.3
HER-2 positive gastric cancer 10.3
Sclerosing hepatic carcinoma 10.3
dermoid inclusion 10.0
metastatic nasopharyngeal cancer 10.0
infected ingrown toenail 10.0
Malignant paraganglioma 9.7
Combined small cell carcinoma 9.7
Pseudohyperparathyroidism 9.5
hypercalcemia of malignancy 9.4
Intra-abdominal metastases 9.3
osteolytic sarcoma 9.3
Spinal metastases 9.3
bone marrow metastases 9.2
Ectopic parathyroid adenoma 9.1
DDU 9.1
pathological fracture 8.9
Periosteal chondrosarcoma 8.8
Head and Neck Tumor 8.8
Omental metastasis 8.8
Numb chin syndrome 8.8
Radiation esophagitis 8.7
Malignant pheochromocytoma 8.7
Oropharyngeal mucositis 8.7
recurrent parathyroid carcinoma 8.7
stage D prostate cancer 8.6
Walker carcinoma 256 8.6
spinal cord compression 8.6
stage II endometrial cancer 8.5
Scirrhous carcinoma 8.5
stage C prostate cancer 8.4
clear cell sarcoma of the kidney 8.4
stage B prostate cancer 8.3
Duodenal cancer 8.3
Hurthle cell carcinoma 8.2
osteopoikilosis 8.1
unknown primary cancer 8.1
Transverse colon 8.0
Transverse colon 8.0
metastatic follicular thyroid cancer 8.0
bone disease 8.0
esophageal irritation 8.0
Vertebral column 8.0
Progression of prostate cancer 8.0
Vertebral column 8.0
Cystic kidney disease 8.0
Malignant granular cell tumor 8.0
Pleomorphic carcinoma 7.9
bone abscess 7.9
ZD1 7.9
metastatic pheochromocytoma 7.9
stage IV renal cell carcinoma 7.8
bone cancer 7.8
bone marrow cancer 7.8
hypercalcemia 7.8
recurrent prostate cancer 7.7
Clear cell chondrosarcoma 7.5
Polyostotic fibrous dysplasia 7.5
Renal pelvis 7.5
Paget's Disease 7.5
Renal pelvis 7.5
recurrent pheochromocytoma 7.5
hormone refractory prostate cancer 7.4
Mediastinal lymphadenopathy 7.4
Cystic disease 7.4
Bone marrow toxicity 7.4
Adrenal metastases 7.4
dysbasia 7.4
Dedifferentiated chondrosarcoma 7.4
recurrent breast cancer 7.4
Brown tumor 7.3
metastatic rectal cancer 7.3
pelvic neoplasm 7.3
testicular yolk sac tumor 7.3
Pilomatrix carcinoma 7.2
Primary osteoporosis 7.2
Cardia 7.2
more...
Symptom
Pain from metastases 12.3
abnormal urination 10.0
bone pain 9.4
feeling exhausted 8.4
Flaccid paralysis 8.1
unable to sleep 7.8
neurological pain 7.4
Flare 6.8
carpopedal spasm 6.8
koilonychia 6.6
breakthrough pain 6.6
Flu-like symptoms 6.5
Pain symptoms 6.5
GI irritation 6.3
renal pain 6.2
cancer pain 6.1
Sister Mary Joseph's nodule 6.1
peau d'orange 5.8
Cushingoid 5.5
Cushingoid 5.5
left upper quadrant pain 5.3
abdominal fullness 5.2
prostatism 5.1
Severe pain 5.0
exertional chest pain 5.0
arm pain 4.9
jaw pain 4.8
hot flashes 4.6
hip pain 4.5
leg edema 4.5
back pain 4.5
pain 4.4
body pain 4.2
non-productive cough 4.2
visual hallucination 4.1
halitosis 4.1
cachexia 3.8
low back pain 3.7
shoulder pain 3.7
consciousness disturbance 3.6
wrist pain 3.6
nausea 3.5
nausea and vomiting 3.5
flank pain 3.5
heel pain 3.4
lightheadedness 3.3
numbness 3.3
hyperesthesia 3.2
asthenia 3.2
ankle pain 3.2
swollen joints 3.2
polydipsia 3.2
neck pain 3.2
knee pain 3.1
productive cough 3.1
epigastric pain 3.1
abdominal discomfort 3.1
excessive sweating 3.1
pleuritic chest pain 3.1
chills 3.0
polyuria 3.0
dysuria 3.0
hot flushes 3.0
analgesia 3.0
tingling 3.0
rales 3.0
shortness of breath 2.9
thigh pain 2.9
leg pain 2.9
anorexia 2.9
sciatica 2.7
acute pain 2.7
renal colic 2.6
myalgia 2.6
rigors 2.6
dyspnea 2.6
hepatomegaly 2.6
paresis 2.6
vomiting 2.5
paraparesis 2.4
more...
Drug
Zoledronic acid 10.4
Aredia 10.4
Quadramet 10.2
Mesnex 10.0
Zoledronic acid 9.9
Bonefos 9.8
Denosumab 9.7
Ibandronate 9.4
Etidronate disodium 8.7
EHDP 8.7
Clodronate 8.7
Flurbiprofen axetil 8.6
SrCl2 8.3
Gallium nitrate 8.3
ProstaScint 8.3
Fareston 8.3
Percocet 8.3
Fareston 8.2
Parnate 8.0
Roferon A 7.9
Edatrexate 7.9
Iguratimod 7.6
Ibritumomab tiuxetan 7.6
Elcatonin 7.5
Epidoxorubicin 7.5
Vorozole 7.0
Estracyt 7.0
Interferon alfa-2a 6.9
Estracyt 6.9
Sandostatin LAR 6.8
Leukine 6.8
Salmon calcitonin 6.8
APD 6.7
Arimidex 6.7
DMSA 6.3
Pertuzumab 6.2
Fosamax 6.1
Docetaxel 6.0
SrCl2 5.9
Rasburicase 5.8
Ziconotide 5.8
Diamminedichloroplatinum 5.6
CA-074 5.5
Intron A 5.5
Morphine sulfate 5.4
Dutasteride 5.4
IL-11 5.3
Ipriflavone 5.3
Zevalin 5.3
Zoladex 5.3
Intron A 5.3
Axitinib 5.2
Gefitinib 5.2
Intron A 5.2
Vandetanib 5.2
Vinorelbine 5.1
Eptifibatide 5.1
Zoladex 5.0
Thyroglobulin 4.9
Leucovorin 4.9
Navelbine 4.8
Casodex 4.7
Dasatinib 4.6
Lupron 4.6
NOV 4.6
PTH 4.5
Everolimus 4.4
CPT-11 4.4
SnF2 4.4
Orion 4.4
Erlotinib 4.3
OIF 4.3
Rasburicase 4.3
Adriamycin 4.3
CPM 4.1
Ketorolac 4.1
CTX 4.1
CTX 4.0
Sorafenib 4.0
Sandostatin 4.0
more...
Enzyme
MDP 7.4
prostate-specific membrane antigen 7.3
prostate-specific antigen 6.7
cathepsin K 6.5
sarcosine dehydrogenase 6.5
collagenase 3 6.3
proline iminopeptidase 5.3
hepsin 5.1
hepsin 5.1
glycine N-methyltransferase 5.0
proteinase A 4.8
carboxypeptidase G2 4.8
PMT 4.6
alkaline phosphatase 4.6
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.6
dihydropyrimidine dehydrogenase 4.6
PTR 4.5
type III procollagen 4.4
lysyl oxidase 4.3
matriptase 4.3
CPL 4.3
proteinase A 4.2
acid phosphatase 4.2
uridine phosphorylase 4.0
CPM 3.9
proteinase-3 3.9
matriptase 3.7
FAST 3.7
PAL 3.6
choline kinase 3.5
ALDH 3.5
lactic acid dehydrogenase 3.4
MMP 3.4
lactic acid dehydrogenase 3.4
phosphoribulokinase 3.3
PAL 3.2
ADPase 3.2
matrix metalloproteinase 9 3.2
ERK 3.1
MTD 3.1
HDR 3.0
prenyltransferase 3.0
endothelin-converting enzyme 3.0
MMP-3 2.9
cathepsin B 2.8
firefly luciferase 2.8
deoxycytidine kinase 2.8
sphingosine kinase 2.7
lactic acid dehydrogenase 2.7
diamine oxidase 2.6
urokinase-type plasminogen activator 2.6
PAT 2.6
BMA 2.5
interstitial collagenase 2.4
MIP 2.3
SCS 2.3
nucleotidase 2.3
thymidine phosphorylase 2.3
farnesyltransferase 2.3
proprotein convertase 2.2
aldehyde dehydrogenase 2.2
aldehyde dehydrogenase 2.2
aldehyde dehydrogenase 2.2
21-hydroxylase 2.1
lactate dehydrogenase 2.1
Thy1 2.0
aldehyde dehydrogenase 2.0
luciferase 1.9
BMT 1.9
sialidase 1.9
tryptase 1.8
focal adhesion kinase 1.8
TOR 1.8
MAT 1.7
farnesyltransferase 1.7
gamma-glutamyl transpeptidase 1.7
apyrase 1.7
thyroid peroxidase 1.7
aldehyde dehydrogenase 1.6
PRA 1.6
more...
Compound
Pamidronate 9.4
Chlormerodrin 9.0
EHDP 8.8
Mitozolomide 8.6
7-methoxy-2H-chromen-2-one 8.1
Kadsurenone 7.9
Bicalutamide 7.5
Pyridinoline 7.4
Deoxypyridinoline 7.4
Tiludronate 7.4
THP-ADM 7.3
Carboquone 7.2
NMHE 7.1
Geranylgeraniol 7.1
5-methyltryptophan 7.0
Toremifene 6.9
Carboquone 6.9
Carboquone 6.9
Carboquone 6.9
Carboquone 6.9
Estracyt 6.9
Estracyt 6.9
Risedronate 6.8
N-Hydroxysuccinimide 6.6
strontium 6.5
Aminoglutethimide 6.5
Docetaxel 6.3
Tegafur 6.0
pentanedioic acid 5.7
(S)-4-carboxyphenylglycine 5.7
Estramustine 5.7
Letrozole 5.7
Morphine sulfate 5.6
Androgen 5.6
25-Hydroxyvitamin D 5.5
Embelin 5.5
Diamminedichloroplatinum 5.4
Alendronate 5.4
Tegafur 5.4
FTA 5.3
MDA 5.3
Alendronate 5.2
MPA 5.2
MPA 5.2
Tranylcypromine 5.1
MPA 5.1
DMPE 5.0
A 71 5.0
Leucovorin 5.0
Temsirolimus 4.9
1,4,7,10-tetraazacyclododecane 4.9
IEA 4.9
Osthole 4.8
ALP 4.7
Anastrozole 4.7
PMT 4.6
PTR 4.6
Calcitonin 4.6
Mitoxantrone 4.6
Mithramycin 4.6
BAP 4.6
8-quinolinol 4.5
Mitoxantrone 4.5
CPL 4.5
Sarcosine 4.5
PAP 4.5
Geigy 4.4
Gemcitabine 4.4
CPT-11 4.4
5-FU 4.4
Gemcitabine 4.4
DIC 4.4
Caffeic acid phenethyl ester 4.4
Octreotide 4.3
G 1 4.3
Oxycodone 4.3
VMA 4.3
Ketorolac 4.3
Capecitabine 4.3
PAP 4.2
more...