Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0153690 (bone metastases)
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Human Gene/Protein
minichromosome maintenance 9 11.3
protein FAM134A 11.3
PALM2 10.7
NSUN6 10.7
C6orf167 10.7
MFAP3L 10.7
STIP1 protein 10.3
SFT2D2 10.0
Cell surface glycoprotein 10.0
Kallikrein-related peptidase 4 10.0
OATP5A1 9.5
proline/arginine-rich end leucine-rich repeat protein 9.3
MAGEA2 9.0
Microfibrillar-associated protein 5 9.0
aldehyde dehydrogenase 1A3 9.0
neural cell adhesion protein 8.8
KRT23 8.7
LLGL2 8.7
ALDH3B2 8.6
NIP7 8.6
killer-specific secretory protein of 37 kDa 8.5
KCNS1 8.5
MYOF 8.5
ATL2 8.5
Ral guanine nucleotide exchange factor 8.5
SCN7A 8.4
lymphocyte-specific protein 1 8.4
FAM84B 8.4
NUP155 8.3
bone-type alkaline phosphatase 8.3
PLCB3 8.3
STEAP2 8.2
MPC3 8.2
DEP domain containing 1 8.2
KHDRBS1 8.1
ADAMTS14 8.1
Bone morphogenetic protein 7 8.0
GYPC 8.0
parathyroid hormone-related protein 8.0
CA15 8.0
more...
Disease
bone metastases 12.3
Thoracic neuroblastoma 12.3
Stage IV Prostate Adenocarcinoma 12.3
Desmoplastic mesothelioma 11.3
Sclerosing hepatic carcinoma 10.3
HER-2 positive gastric cancer 10.3
metastatic nasopharyngeal cancer 10.0
infected ingrown toenail 10.0
dermoid inclusion 10.0
Malignant paraganglioma 9.7
Combined small cell carcinoma 9.7
Pseudohyperparathyroidism 9.5
hypercalcemia of malignancy 9.4
Intra-abdominal metastases 9.3
osteolytic sarcoma 9.3
Spinal metastases 9.3
bone marrow metastases 9.2
Ectopic parathyroid adenoma 9.1
DDU 9.1
pathological fracture 8.9
Periosteal chondrosarcoma 8.8
Head and Neck Tumor 8.8
Omental metastasis 8.8
Numb chin syndrome 8.8
Malignant pheochromocytoma 8.7
Oropharyngeal mucositis 8.7
Radiation esophagitis 8.7
recurrent parathyroid carcinoma 8.7
stage D prostate cancer 8.6
Walker carcinoma 256 8.6
spinal cord compression 8.6
stage II endometrial cancer 8.5
Scirrhous carcinoma 8.5
stage C prostate cancer 8.4
clear cell sarcoma of the kidney 8.4
Duodenal cancer 8.3
stage B prostate cancer 8.3
Hurthle cell carcinoma 8.2
osteopoikilosis 8.1
unknown primary cancer 8.1
more...
Symptom
Pain from metastases 12.3
abnormal urination 10.0
bone pain 9.4
feeling exhausted 8.4
Flaccid paralysis 8.1
unable to sleep 7.8
neurological pain 7.4
Flare 6.8
carpopedal spasm 6.8
koilonychia 6.6
breakthrough pain 6.6
Flu-like symptoms 6.5
Pain symptoms 6.5
GI irritation 6.3
renal pain 6.2
cancer pain 6.1
Sister Mary Joseph's nodule 6.1
peau d'orange 5.8
Cushingoid 5.5
Cushingoid 5.5
left upper quadrant pain 5.3
abdominal fullness 5.2
prostatism 5.1
Severe pain 5.0
exertional chest pain 5.0
arm pain 4.9
jaw pain 4.8
hot flashes 4.6
hip pain 4.5
leg edema 4.5
back pain 4.5
pain 4.4
body pain 4.2
non-productive cough 4.2
visual hallucination 4.1
halitosis 4.1
cachexia 3.8
low back pain 3.7
shoulder pain 3.7
consciousness disturbance 3.6
more...
Drug
Zoledronic acid 10.4
Aredia 10.4
Quadramet 10.2
Mesnex 10.0
Zoledronic acid 9.9
Bonefos 9.8
Denosumab 9.7
Ibandronate 9.4
Etidronate disodium 8.7
EHDP 8.7
Clodronate 8.7
Flurbiprofen axetil 8.6
SrCl2 8.3
Gallium nitrate 8.3
ProstaScint 8.3
Percocet 8.3
Fareston 8.3
Fareston 8.2
Parnate 8.0
Edatrexate 7.9
Roferon A 7.9
Ibritumomab tiuxetan 7.6
Iguratimod 7.6
Elcatonin 7.5
Epidoxorubicin 7.5
Vorozole 7.0
Estracyt 7.0
Interferon alfa-2a 6.9
Estracyt 6.9
Sandostatin LAR 6.8
Leukine 6.8
Salmon calcitonin 6.8
APD 6.7
Arimidex 6.7
DMSA 6.3
Pertuzumab 6.2
Fosamax 6.1
Docetaxel 6.0
SrCl2 5.9
Rasburicase 5.8
more...
Enzyme
MDP 7.4
prostate-specific membrane antigen 7.3
prostate-specific antigen 6.7
cathepsin K 6.5
sarcosine dehydrogenase 6.5
collagenase 3 6.3
proline iminopeptidase 5.3
hepsin 5.1
hepsin 5.1
glycine N-methyltransferase 5.0
proteinase A 4.8
carboxypeptidase G2 4.8
PMT 4.6
alkaline phosphatase 4.6
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.6
dihydropyrimidine dehydrogenase 4.6
PTR 4.5
type III procollagen 4.4
lysyl oxidase 4.3
matriptase 4.3
CPL 4.3
proteinase A 4.2
acid phosphatase 4.2
uridine phosphorylase 4.0
CPM 3.9
proteinase-3 3.9
matriptase 3.7
FAST 3.7
PAL 3.6
choline kinase 3.5
ALDH 3.5
lactic acid dehydrogenase 3.4
MMP 3.4
lactic acid dehydrogenase 3.4
phosphoribulokinase 3.3
PAL 3.2
ADPase 3.2
matrix metalloproteinase 9 3.2
ERK 3.1
MTD 3.1
more...
Compound
Pamidronate 9.4
Chlormerodrin 9.0
EHDP 8.8
Mitozolomide 8.6
7-methoxy-2H-chromen-2-one 8.1
Kadsurenone 7.9
Bicalutamide 7.5
Pyridinoline 7.4
Deoxypyridinoline 7.4
Tiludronate 7.4
THP-ADM 7.3
Carboquone 7.2
NMHE 7.1
Geranylgeraniol 7.1
5-methyltryptophan 7.0
Toremifene 6.9
Carboquone 6.9
Carboquone 6.9
Carboquone 6.9
Carboquone 6.9
Estracyt 6.9
Estracyt 6.9
Risedronate 6.8
N-Hydroxysuccinimide 6.6
strontium 6.5
Aminoglutethimide 6.5
Docetaxel 6.3
Tegafur 6.0
pentanedioic acid 5.7
(S)-4-carboxyphenylglycine 5.7
Estramustine 5.7
Letrozole 5.7
Morphine sulfate 5.6
Androgen 5.6
25-Hydroxyvitamin D 5.5
Embelin 5.5
Diamminedichloroplatinum 5.4
Alendronate 5.4
Tegafur 5.4
FTA 5.3
more...